Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P. W. K. Chung"'
Autor:
Stefan Mrdenovic, Yanping Wang, Lijuan Yin, Gina Chia-Yi Chu, Yan Ou, Michael S. Lewis, Marija Heffer, Edwin M. Posadas, Haiyen E. Zhau, Leland W. K. Chung, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang, Yi Zhang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted cancer therapy may thw
Externí odkaz:
https://doaj.org/article/64d9337c28904376b1c490cb73e2bfef
Autor:
Lijuan Yin, Qinlong Li, Stefan Mrdenovic, Gina Chia-Yi Chu, Boyang Jason Wu, Hong Bu, Peng Duan, Jayoung Kim, Sungyong You, Michael S. Lewis, Gangning Liang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis. The objecti
Externí odkaz:
https://doaj.org/article/81fdffabdd8947c88d1526d072f838ac
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The human fetal osteoblast cell line (hFOB 1.19) has been proposed as an accessible experimental model for study of osteoblast biology relating to drug development and biomaterial engineering. For their multilineage differentiation potential
Externí odkaz:
https://doaj.org/article/004ee85307cc48c09f62539ad1ee1a48
Autor:
Zhi Cao, Xiaolei Shi, Feng Tian, Yu Fang, Jason Boyang Wu, Stefan Mrdenovic, Xinwen Nian, Jin Ji, Huan Xu, Chen Kong, Yalong Xu, Xi Chen, Yuhua Huang, Xuedong Wei, Yongwei Yu, Bo Yang, Leland W. K. Chung, Fubo Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell. However, how this histone modifier affects the progression of
Externí odkaz:
https://doaj.org/article/d638d6981b494bdf804b0c1b96a7bb4f
Autor:
Chia-Ling Hsieh, Che-Ming Liu, Hsin-An Chen, Shun-Tai Yang, Katsumi Shigemura, Koichi Kitagawa, Fukashi Yamamichi, Masato Fujisawa, Yun-Ru Liu, Wei-Hua Lee, Kuan-Chou Chen, Chia-Ning Shen, Cheng-Chieh Lin, Leland W. K. Chung, Shian-Ying Sung
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Studies on the aberrant control of extracellular matrices (ECMs) have mainly focused on the role of malignant cells but less on that of stromal fibroblasts during cancer development. Herein, by using paired normal and prostate cancer-associa
Externí odkaz:
https://doaj.org/article/b3c9b9a6d5f74bdda45fa2a9e1e37c22
Autor:
Shian-Ying Sung, Junn-Liang Chang, Kuan-Chou Chen, Shauh-Der Yeh, Yun-Ru Liu, Yen-Hao Su, Chia-Yen Hsueh, Leland W K Chung, Chia-Ling Hsieh
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153350 (2016)
Stromal-epithelial interaction has been shown to promote local tumor growth and distant metastasis. We sought to create a promising gene therapy approach that co-targets cancer and its supporting stromal cells for combating castration-resistant prost
Externí odkaz:
https://doaj.org/article/00d6e1394c3e40229c35e7804a9aa7c4
Publikováno v:
Landslides. 17:243-247
Given the climatic and geographical setting, Hong Kong is vulnerable to landslide risk. The poignant history of landslides catalysed the establishment of the Geotechnical Engineering Office (GEO hereafter) in 1977. Since then, a comprehensive Slope S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d0dce87b2da6fcdeac976fce57fabb
https://doi.org/10.1007/s10346-019-01291-8
https://doi.org/10.1007/s10346-019-01291-8
Autor:
Bethany N Smith, Liza J Burton, Veronica Henderson, Diandra D Randle, Derrick J Morton, Basil A Smith, Latonia Taliaferro-Smith, Peri Nagappan, Clayton Yates, Majd Zayzafoon, Leland W K Chung, Valerie A Odero-Marah
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104987 (2014)
Snail transcription factor is up-regulated in several cancers and associated with increased tumor migration and invasion via induction of epithelial-to-mesenchymal transition (EMT). MAPK (ERK1/2) signaling regulates cellular processes including cell
Externí odkaz:
https://doaj.org/article/d1a6e9c32d6a46d996074e68b30dc4fc
Autor:
Chen Shao, Chun-Peng Liao, Peizhen Hu, Chia-Yi Chu, Lei Zhang, Matthew H T Bui, Christopher S Ng, David Y Josephson, Beatrice Knudsen, Mourad Tighiouart, Hyung L Kim, Haiyen E Zhau, Leland W K Chung, Ruoxiang Wang, Edwin M Posadas
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88967 (2014)
Tumor cells are inherently heterogeneous and often exhibit diminished adhesion, resulting in the shedding of tumor cells into the circulation to form circulating tumor cells (CTCs). A fraction of these are live CTCs with potential of metastatic colon
Externí odkaz:
https://doaj.org/article/f20d7fb1586a4fdcb41fde099577b50c
Autor:
Peizhen Hu, Leland W K Chung, Dror Berel, Henry F Frierson, Hua Yang, Chunyan Liu, Ruoxiang Wang, Qinlong Li, Andre Rogatko, Haiyen E Zhau
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73081 (2013)
We reported (PLoS One 6 (12):e28670, 2011) that the activation of c-Met signaling in RANKL-overexpressing bone metastatic LNCaP cell and xenograft models increased expression of RANK, RANKL, c-Met, and phosphorylated c-Met, and mediated downstream si
Externí odkaz:
https://doaj.org/article/78db664fa4b14490a60f4834bcb27a71