Zobrazeno 1 - 10
of 21
pro vyhledávání: '"P. W. Holden"'
Autor:
Xiu-Jun Yu, Haixia Xie, Yan Li, Mei Liu, Ruhong Hou, Alexander V. Predeus, Blanca M. Perez Sepulveda, Jay C. D. Hinton, David W. Holden, Teresa L. M. Thurston
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The injectisome encoded by Salmonella pathogenicity island 2 (SPI-2) had been thought to translocate 28 effectors. Here, we used a proteomic approach to characterize the secretome of a clinical strain of invasive non-typhoidal Salmonella ent
Externí odkaz:
https://doaj.org/article/9ff9398d46de4a18a5884c97770df61d
Autor:
Kimberley Allen-Philbey, Stefania De Trane, Amy MacDougall, Ashok Adams, Lucia Bianchi, Thomas Campion, Gavin Giovannoni, Sharmilee Gnanapavan, David W. Holden, Monica Marta, Joela Mathews, Benjamin P. Turner, David Baker, Klaus Schmierer
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Cladribine is an effective immunotherapy for people with multiple sclerosis (pwMS). Whilst most pwMS do not require re-treatment following standard dosing (two treatment courses), disease activity re-emerges in others. The characteristics
Externí odkaz:
https://doaj.org/article/fd516c91925d472ea3fce1497656f468
Publikováno v:
Pediatric Reports, Vol 14, Iss 2, Pp 244-253 (2022)
Time-out, a mainstay of non-punitive discipline for over 60 years, has been criticized for isolating and distancing children from others. An alternative technique, one promoted by advocates of positive parenting practices, is labeled “time-in”. T
Externí odkaz:
https://doaj.org/article/a074fd3372df4ece9eafbfa3118496d5
Autor:
Tracie O. Afifi, Samantha Salmon, Ashley Stewart-Tufescu, Tamara Taillieu, Janique Fortier, Harriet MacMillan, Joan Durrant, George W. Holden
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Research consistently demonstrates that physical punishment of children including “spanking” is harmful. Interest in effective prevention is growing rapidly. The aim of the current study is to examine spanking beliefs among ad
Externí odkaz:
https://doaj.org/article/3a35eb78ade146e586ba5cedd315b7cb
Autor:
Camilla Godlee, Ondrej Cerny, Mei Liu, Samkeliso Blundell, Alanna E Gallagher, Meriam Shahin, David W Holden
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010252 (2022)
SteD is a transmembrane effector of the Salmonella SPI-2 type III secretion system that inhibits T cell activation by reducing the amounts of at least three proteins -major histocompatibility complex II (MHCII), CD86 and CD97 -from the surface of ant
Externí odkaz:
https://doaj.org/article/79473fe5ba0146eea0373a2e9453addf
Autor:
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E Cross, Haoran Shi, James C Williamson, Eric Alix, Paul J Lehner, David W Holden
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009771 (2021)
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the Nedd4 family HECT E3
Externí odkaz:
https://doaj.org/article/b5bb0f4a261a40268794702055b6fea8
Autor:
Kathleen M. McAndrews, Dara P. Dowlatshahi, Jianli Dai, Lisa M. Becker, Janine Hensel, Laura M. Snowden, Jennifer M. Leveille, Michael R. Brunner, Kylie W. Holden, Nikolas S. Hopkins, Alexandria M. Harris, Jerusha Kumpati, Michael A. Whitt, J. Jack Lee, Luis L. Ostrosky-Zeichner, Ramesha Papanna, Valerie S. LeBleu, James P. Allison, Raghu Kalluri
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Evaluation of potential immunity against the novel severe acute respiratory syndrome (SARS) coronavirus that emerged in 2019 (SARS-CoV-2) is essential for health, as well as social and economic recovery. Generation of antibody response to SARS-CoV-2
Externí odkaz:
https://doaj.org/article/14380a2126494c5997b4a423aaacd717
Autor:
Teresa L. M. Thurston, Sophie A. Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R. Shenoy, Mark A. Birrell, David W. Holden
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has an
Externí odkaz:
https://doaj.org/article/3dcaf1a910524de0b958aea81b142880
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Nonflagellar type III secretion systems (nf T3SSs) form a cell surface needle-like structure and an associated translocon that deliver bacterial effector proteins into eukaryotic host cells. This involves a tightly regulated hierarchy of pro
Externí odkaz:
https://doaj.org/article/c3e4c1e85fce48b684b04a1bb4a34047
Autor:
David W. Holden, Jeff Errington
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
Externí odkaz:
https://doaj.org/article/35d5109ad4dd42f696feea899ce42138