Výsledky vyhledávání - "P. V. PEDONE"

Akademický článek

A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells

Autor: Nicola Landi, Vincenza Ciaramella, Sara Ragucci, Angela Chambery, Fortunato Ciardiello, Paolo V. Pedone, Teresa Troiani, Antimo Di Maro

Publikováno v: Toxins, Vol 15, Iss 1, p 57 (2023)

Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence o

Externí odkaz: https://doaj.org/article/9a09573074fd400b8851133f7ddeb361

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Akademický článek

Ribotoxic Proteins, Known as Inhibitors of Protein Synthesis, from Mushrooms and Other Fungi According to Endo’s Fragment Detection

Autor: Nicola Landi, Hafiza Z. F. Hussain, Paolo V. Pedone, Sara Ragucci, Antimo Di Maro

Publikováno v: Toxins, Vol 14, Iss 6, p 403 (2022)

rRNA N-glycosylases (EC 3.2.2.22) remove a specific adenine (A4324, rat 28S rRNA) in the sarcin ricin loop (SRL) involved into ribosome interaction with elongation factors, causing the inhibition of translation, for which they are known as plant ‘r

Externí odkaz: https://doaj.org/article/db1d3312cf994ccea6f3ae4c1620adf1

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Akademický článek

Ageritin—The Ribotoxin-like Protein from Poplar Mushroom (Cyclocybe aegerita) Sensitizes Primary Glioblastoma Cells to Conventional Temozolomide Chemotherapy

Autor: Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Nicola Landi, Maria Antonietta Oliva, Paolo V. Pedone, Antimo Di Maro, Antonietta Arcella

Publikováno v: Molecules, Vol 27, Iss 8, p 2385 (2022)

Here, we propose Ageritin, the prototype of the ribotoxin-like protein family, as an adjuvant treatment to control the growth of NULU and ZAR, two primary human glioblastoma cell lines, which exhibit a pharmacoresistance phenotype. Ageritin is able t

Externí odkaz: https://doaj.org/article/243dbeb3c4154dbcbcbaa98321cb5f53

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Akademický článek

An Updated Review of Bioactive Peptides from Mushrooms in a Well-Defined Molecular Weight Range

Autor: Nicola Landi, Angela Clemente, Paolo V. Pedone, Sara Ragucci, Antimo Di Maro

Publikováno v: Toxins, Vol 14, Iss 2, p 84 (2022)

Here, we report the current status of the bioactive peptides isolated and characterized from mushrooms during the last 20 years, considering ‘peptide’ a succession from to 2 to 100 amino acid residues. According to this accepted biochemical defin

Externí odkaz: https://doaj.org/article/974f077175ac4df2870587f0b7889969

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Akademický článek

Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells

Autor: Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Maria Antonietta Oliva, Nicola Landi, Paolo V. Pedone, Antonietta Arcella, Antimo Di Maro

Publikováno v: Toxins, Vol 13, Iss 10, p 684 (2021)

Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cell

Externí odkaz: https://doaj.org/article/8d52fb8350494b4b8dd7339bfa4a3caf

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Theoretical and experimental structural studies on the carboxyl-terminal portion of the excitatory amino acid transporter EAAT2. Implications for the design of new neuroprotective agents

Autor: FATTORUSSO, CATERINA, L. RAIOLA, CATALANOTTI, BRUNO, L. ZACCARO, A. DEL GATTO, R. FATTORUSSO, P. V. PEDONE, C. ISERNIA B. DI BLASIO AND G. CAMPIANI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::c588f0683474006c1b8dd75d259078ab
http://hdl.handle.net/11588/118627

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A multidisciplinary approach to study the carboxyl-terminal portion of the excitatory amino acid transporter EAAT2:implications for the design of new neuroprotective agents

Autor: L. RAIOLA, PERSICO, MARCO, M. BORRIELLO, CATALANOTTI, BRUNO, L. ZACCARO, A. DEL GATTO, R. FATTORUSSO, G. CAMPIANI, P. V. PEDONE, C. ISERNIA AND B. DI BLASIO, FATTORUSSO, CATERINA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::4d6eb5209997c115edb9304ab7164fda
http://hdl.handle.net/11588/118628

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Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene

Autor: A, Riccio, P V, Pedone, L R, Lund, T, Olesen, H S, Olsen, P A, Andreasen

Publikováno v: Molecular and cellular biology. 12(4)

Transforming growth factor beta (TGF-beta) is the name of a group of closely related polypeptides characterized by a multiplicity of effects, including regulation of extracellular proteolysis and turnover of the extracellular matrix. Its cellular mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68971ed9be02c76cb78629b4d6b8006c
https://pubmed.ncbi.nlm.nih.gov/1549130

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TRANSFORMING GROWTH FACTOR-BETA-1-RESPONSIVE ELEMENT - CLOSELY ASSOCIATED BINDING-SITES FOR USF AND CCAAT-BINDING TRANSCRIPTION FACTOR-NUCLEAR FACTOR-I IN THE TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR GENE

Autor: A Riccio, P V Pedone, L R Lund, T Olesen, H S Olsen, P A Andreasen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25aad0e9084d3569f44a5fb22522e0df
http://hdl.handle.net/11591/227926

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