Zobrazeno 1 - 10
of 1 255
pro vyhledávání: '"P. Tfelt Hansen"'
Autor:
Brando Poggiali, Mikkel Eriksen Dupont, Stine Bøttcher Jacobsen, Morten Holdgaard Smerup, Steffan Noe Niikanoff Christiansen, Jacob Tfelt-Hansen, Athina Vidaki, Niels Morling, Jeppe Dyrberg Andersen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Investigating DNA methylation (DNAm) in cardiac tissues is vital for epigenetic research in cardiovascular diseases (CVDs). During cardiac surgery, biopsies may not be immediately stored due to a lack of human or technical resources at the c
Externí odkaz:
https://doaj.org/article/a93c7b8f90164297a5200927d8731800
Autor:
Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB). The aim of this study was therefore to determine if triptans pass th
Externí odkaz:
https://doaj.org/article/b334ddd2966948df88ef0d2a29430da2
Autor:
Caroline J. Coats, Ahmad Masri, Michael E. Nassif, Roberto Barriales‐Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Hans‐Dirk Düngen, Pablo Garcia‐Pavia, Albert A. Hagège, James L. Januzzi, Matthew M. Y. Lee, Gregory D. Lewis, Chang‐Sheng Ma, Martin S. Maron, Zi Michael Miao, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt‐Hansen, Marion van Sinttruije, Josef Veselka, Hugh Watkins, Daniel L. Jacoby, Polina German, Stephen B. Heitner, Stuart Kupfer, Justin D. Lutz, Fady I. Malik, Lisa Meng, Amy Wohltman, Theodore P. Abraham
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)
Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces cardiac hypercontractility in obstructive hypertrophic cardiomyopathy. We present a prespecified analysis of the pharmacokinetics, pharmacodynamics, and safety of aficamten in
Externí odkaz:
https://doaj.org/article/ecd7f5b3949f4a8ca276c42cd7292a3f
Autor:
Mie Rath Refn, Mikkel Meyer Andersen, Marie-Louise Kampmann, Jacob Tfelt-Hansen, Erik Sørensen, Margit Hørup Larsen, Niels Morling, Claus Børsting, Vania Pereira
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract DNA methylation, a pivotal epigenetic modification, plays a crucial role in regulating gene expression and is known to undergo dynamic changes with age. The present study investigated epigenome-wide methylation profiles in 64 individuals ove
Externí odkaz:
https://doaj.org/article/143c3d298673469aa0adeb44daf008e8
Autor:
Mikkel Eriksen Dupont, Stine Bøttcher Jacobsen, Steffan Noe Niikanoff Christiansen, Jacob Tfelt-Hansen, Morten Holdgaard Smerup, Jeppe Dyrberg Andersen, Niels Morling
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Untreated fresh cardiac tissue is the optimal tissue material for investigating DNA methylation patterns of cardiac biology and diseases. However, fresh tissue is difficult to obtain. Therefore, tissue stored as frozen or formalin-fixed, par
Externí odkaz:
https://doaj.org/article/8e82ee68189f4169ad2396f415d01eb0
Autor:
Nunu Laura Timotheussen Lund, Anja Sofie Petersen, Rolf Fronczek, Jacob Tfelt-Hansen, Andrea Carmine Belin, Tore Meisingset, Erling Tronvik, Anna Steinberg, Charly Gaul, Rigmor Højland Jensen
Publikováno v:
The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Aim Treatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is unspecific and based on few and small studies not adhering to modern standards. Therefore, the authors collaborated to
Externí odkaz:
https://doaj.org/article/6cc9183bf3c34d3f9e1200835e3d2942
Autor:
Lisette J. A. Kogelman, Katrine Falkenberg, Filip Ottosson, Madeleine Ernst, Francesco Russo, Valdemar Stentoft-Hansen, Samuel Demharter, Peer Tfelt-Hansen, Arieh S. Cohen, Jes Olesen, Thomas Folkmann Hansen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Migraine is a common, polygenic disorder that is characterized by moderate to severe headache attacks. Migraine attacks are commonly treated with triptans, i.e. serotonin receptor agonists. However, triptans are effective in ~ 60% of the pop
Externí odkaz:
https://doaj.org/article/019b32d50c554687bdf123c45787a1b2
Autor:
Paulina Pruszkowska-Przybylska, Mikkel Eriksen Dupont, Stine Bøttcher Jacobsen, Morten Smerup, Jacob Tfelt-Hansen, Niels Morling, Jeppe Dyrberg Andersen
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0299557 (2024)
The continued development in methylome analysis has enabled a more precise assessment of DNA methylation, but treatment of target tissue prior to analysis may affect DNA analysis. Prediction of age based on methylation levels in the genome (DNAmAge)
Externí odkaz:
https://doaj.org/article/6cf5d5cdb18e411c97a71a06bb6e02ca
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