Zobrazeno 1 - 10
of 2 090
pro vyhledávání: '"P. Terho"'
Autor:
Ek, Kaisa, Avela, Aleksi, Haaki, Willehard, Helander, Sami, Lumme, Ville, Mutikainen, Terho, Pere, Jaakko, Vesselinova, Natalia, Viitasaari, Lauri, Ilmonen, Pauliina
The recent COVID-19 pandemic has highlighted the need of studying extreme, life-threatening phenomena in advance. In this article, a zombie epidemic in Uusimaa region in Finland is modeled. A stochastic agent based simulation model is proposed and ex
Externí odkaz:
http://arxiv.org/abs/2410.12502
Autor:
Li, Jie, Hourican, Cillian, Mishra, Pashupati P., Mishra, Binisha H., Kähönen, Mika, Raitakari, Olli T., Laaksonen, Reijo, Ala-Korpela, Mika, Keltikangas-Järvinen, Liisa, Juonala, Markus, Lehtimäki, Terho, Bosch, Jos A., Quax, Rick
Cardiovascular diseases (CVD) and depression exhibit significant comorbidity, which is highly predictive of poor clinical outcomes. Yet, the underlying biological pathways remain challenging to decipher, presumably due to the non-linear associations
Externí odkaz:
http://arxiv.org/abs/2408.07562
This paper focuses on a mixed-integer programming formulation for influence diagrams, based on a gradual rooted junction tree representation of the diagram. We show that different risk considerations, including chance constraints and conditional valu
Externí odkaz:
http://arxiv.org/abs/2401.03734
Autor:
Matsumoto, Nicholas, Saini, Anil Kumar, Ribeiro, Pedro, Choi, Hyunjun, Orlenko, Alena, Lyytikäinen, Leo-Pekka, Laurikka, Jari O, Lehtimäki, Terho, Batista, Sandra, Moore, Jason H.
In many evolutionary computation systems, parent selection methods can affect, among other things, convergence to a solution. In this paper, we present a study comparing the role of two commonly used parent selection methods in evolving machine learn
Externí odkaz:
http://arxiv.org/abs/2302.00731
Autor:
Marina O. Rontogianni, Dipender Gill, Emmanouil Bouras, Alexandros-Georgios Asimakopoulos, Ioanna Tzoulaki, Ville Karhunen, Terho Lehtimäki, Olli Raitakari, Matthias Wielscher, Veikko Salomaa, Sirpa Jalkanen, Marko Salmi, Markku Timonen, James Yarmolinsky, Jing Chen, Martin D. Tobin, Abril G. Izquierdo, Karl-Heinz Herzig, Anne E. Ioannides, Marjo-Riitta Jarvelin, Abbas Dehghan, Konstantinos K. Tsilidis
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110704- (2024)
Summary: We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization
Externí odkaz:
https://doaj.org/article/eeb3d7c82b994b05a0ca4ff542ec24dc
Autor:
Gabin Drouard, Juha Mykkänen, Jarkko Heiskanen, Joona Pohjonen, Saku Ruohonen, Katja Pahkala, Terho Lehtimäki, Xiaoling Wang, Miina Ollikainen, Samuli Ripatti, Matti Pirinen, Olli Raitakari, Jaakko Kaprio
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class imbalances. However,
Externí odkaz:
https://doaj.org/article/90c753918c9f424a824506ed900513e9
Autor:
Annefleur C. Langedijk, Bram Vrancken, Robert Jan Lebbink, Deidre Wilkins, Elizabeth J. Kelly, Eugenio Baraldi, Abiel Homero Mascareñas de Los Santos, Daria M. Danilenko, Eun Hwa Choi, María Angélica Palomino, Hsin Chi, Christian Keller, Robert Cohen, Jesse Papenburg, Jeffrey Pernica, Anne Greenough, Peter Richmond, Federico Martinón-Torres, Terho Heikkinen, Renato T. Stein, Mitsuaki Hosoya, Marta C. Nunes, Charl Verwey, Anouk Evers, Leyla Kragten-Tabatabaie, Marc A. Suchard, Sergei L. Kosakovsky Pond, Chiara Poletto, Vittoria Colizza, Philippe Lemey, Louis J. Bont, on behalf of the INFORM-RSV Study Group
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory v
Externí odkaz:
https://doaj.org/article/45e7038869c54007951a43a1f120bf0b
Autor:
Joanna Graichen, Carlo Stingl, Anni Pakarinen, Riitta Rosio, Kirsi Terho, Sebastian A. Günther, Sanna Salanterä, Thorsten Staake
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Contagious diseases that affect young children place a great burden on them and their families. Proper hand hygiene is an important measure to reduce the disease burden, however, its implementation in day care centres is challenging. This pa
Externí odkaz:
https://doaj.org/article/e6c1829adff945a28c3f54c38af120cd
Autor:
Joanna Ciantar, Saara Marttila, Sonja Rajić, Daria Kostiniuk, Pashupati P Mishra, Leo-Pekka Lyytikäinen, Nina Mononen, Marcus E Kleber, Winfried März, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Emma Raitoharju
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Eastern and Western Finns show a striking difference in coronary heart disease-related mortality; genetics is a known contributor for this discrepancy. Here, we discuss the potential role of DNA methylation in mediating the discrepancy in cardiometab
Externí odkaz:
https://doaj.org/article/2663fb4c7f7945c0a574ba69c589f2e4
Autor:
Erika Kähönen, Emilia Kähönen, Kristiina Pälve, Janne Hulkkonen, Mika Kähönen, Olli T. Raitakari, Nina Hutri, Terho Lehtimäki, Heikki Aatola
Publikováno v:
Blood Pressure, Vol 33, Iss 1 (2024)
AbstractPurpose Socioeconomic status has been related to resting blood pressure (BP) levels at different stages of life. However, the association of childhood socioeconomic status (SES) and adulthood exercise BP is largely unknown. Therefore, we stud
Externí odkaz:
https://doaj.org/article/3a5252eaecee4105ab07a9093c27aadb