RSM01, a novel respiratory syncytial virus monoclonal antibody: preclinical characterization and results of a first-in-human, randomised clinical trial

Autor: Aurelio Bonavia, Micha Levi, Harald Rouha, Adriana Badarau, Jonne Terstappen, Shayne Watson, Aparna B. Anderson, Joleen T. White, Jintanat Ananworanich, Dale Taylor, Andrijana Radivojevic, Michael Shaffer, Luisa M. Stamm, Michael W. Dunne

Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-18 (2024)

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease among infants and young children worldwide, especially in low- and middle-income countries (LMICs). RSM01 is a novel, highly potent, half-life

Externí odkaz: https://doaj.org/article/3ffe0c8237c54af09d428ce7e5dc02ba

Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury—a randomized, double-blind, and placebo-controlled pilot study

Autor: Dana M. Otzel, Larissa Nichols, Christine F. Conover, Stephen A. Marangi, Jayachandra R. Kura, Dominic K. Iannaccone, David J. Clark, Chris M. Gregory, Christopher F. Sonntag, Anita Wokhlu, Hans K. Ghayee, Michael J. McPhaul, Charles E. Levy, Charles A. Plumlee, Robert B. Sammel, Kevin T. White, Joshua F. Yarrow

Publikováno v: Frontiers in Neurology, Vol 15 (2024)

BackgroundHigh-dose testosterone replacement therapy (TRT), paired with finasteride (type II 5α-reductase inhibitor), improves body composition, muscle strength, and bone mineral density (BMD) in older men, without inducing prostate enlargement—a

Externí odkaz: https://doaj.org/article/d22f66dd5bf64f0a9c7525b00e615faf

Demonstration of event position reconstruction based on diffusion in the NEXT-white detector

Autor: J. Haefner, K. E. Navarro, R. Guenette, B. J. P. Jones, A. Tripathi, C. Adams, H. Almazán, V. Álvarez, B. Aparicio, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Brodolin, N. Byrnes, S. Cárcel, J. V. Carrión, S. Cebrián, E. Church, L. Cid, C. A. N. Conde, T. Contreras, F. P. Cossío, E. Dey, G. Díaz, T. Dickel, M. Elorza, J. Escada, R. Esteve, R. Felkai, L. M. P. Fernandes, P. Ferrario, A. L. Ferreira, F. W. Foss, E. D. C. Freitas, Z. Freixa, J. Generowicz, A. Goldschmidt, J. J. Gómez-Cadenas, R. González, J. Grocott, K. Hafidi, J. Hauptman, C. A. O. Henriques, J. A. Hernando Morata, P. Herrero-Gómez, V. Herrero, C. Hervés Carrete, Y. Ifergan, L. Labarga, L. Larizgoitia, A. Larumbe, P. Lebrun, F. Lopez, N. López-March, R. Madigan, R. D. P. Mano, A. P. Marques, J. Martín-Albo, G. Martínez-Lema, M. Martínez-Vara, Z. E. Meziani, R. L. Miller, K. Mistry, J. Molina-Canteras, F. Monrabal, C. M. B. Monteiro, F. J. Mora, J. Muñoz Vidal, P. Novella, A. Nuñez, D. R. Nygren, E. Oblak, J. Palacio, B. Palmeiro, A. Para, I. Parmaksiz, J. Pelegrin, M. Pérez Maneiro, M. Querol, A. B. Redwine, J. Renner, I. Rivilla, J. Rodríguez, C. Rogero, L. Rogers, B. Romeo, C. Romo-Luque, F. P. Santos, J. M. F. dos Santos, I. Shomroni, A. Simón, S. R. Soleti, M. Sorel, J. Soto-Oton, J. M. R. Teixeira, J. F. Toledo, J. Torrent, A. Trettin, A. Usón, J. F. C. A. Veloso, J. Waiton, J. T. White

Publikováno v: European Physical Journal C: Particles and Fields, Vol 84, Iss 5, Pp 1-13 (2024)

Abstract Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift d

Externí odkaz: https://doaj.org/article/27ed613392a94ababc1288421e3dfaf1

Recommendations for clinical decision-making when offering exoskeletons for community use in individuals with spinal cord injury

Autor: Derrick Onate, Cassandra Hogan, Kathryn Fitzgerald, Kevin T. White, Keith Tansey

Publikováno v: Frontiers in Rehabilitation Sciences, Vol 5 (2024)

Approved in 2014 by the Food and Drug Administration (FDA) for use with a trained companion, personal powered exoskeletons (PPE) for individuals with spinal cord injury (SCI) provide an opportunity for the appropriate candidate to ambulate in their h

Externí odkaz: https://doaj.org/article/8c923f467f404d208c3b1de0b2cb512a

Using serological diagnostics to characterize remaining high-incidence pockets of malaria in forest-fringe Cambodia

Autor: Mathilde Grimée, Costanza Tacoli, Mirco Sandfort, Thomas Obadia, Aimee R. Taylor, Amélie Vantaux, Leanne J. Robinson, Dysoley Lek, Rhea J. Longley, Ivo Mueller, Jean Popovici, Michael T. White, Benoît Witkowski

Publikováno v: Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)

Abstract Background Over the last decades, the number of malaria cases has drastically reduced in Cambodia. As the overall prevalence of malaria in Cambodia declines, residual malaria transmission becomes increasingly fragmented over smaller remote r

Externí odkaz: https://doaj.org/article/c12ecb854bd64b19b26118c1d6c8b064