Zobrazeno 1 - 10
of 75
pro vyhledávání: '"P. T. Sawicki"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including t
Externí odkaz:
https://doaj.org/article/31964fd61b794b31bbdd2edeab37b4e5
Publikováno v:
Bioengineering, Vol 11, Iss 6, p 590 (2024)
Pediatric gait rehabilitation and guidance strategies using robotic exoskeletons require a controller that encourages user volitional control and participation while guiding the wearer towards a stable gait cycle. Virtual constraint-based controllers
Externí odkaz:
https://doaj.org/article/01645f8f8fea4b79b203e3e96534a646
Autor:
Konrad T. Sawicki, Hongyan Ning, Norrina B. Allen, Mercedes R. Carnethon, Amisha Wallia, James D. Otvos, Issam Ben-Sahra, Elizabeth M. McNally, Janet K. Snell-Bergeon, John T. Wilkins
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
BACKGROUND Elevated circulating branched chain amino acids (BCAAs), measured at a single time point in middle life, are strongly associated with an increased risk of developing type 2 diabetes mellitus (DM). However, the longitudinal patterns of chan
Externí odkaz:
https://doaj.org/article/779ab5635c88401293a683894932f4f4
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102064- (2023)
Summary: Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial iron levels. This protocol provides an optimized method for evaluating non-heme and h
Externí odkaz:
https://doaj.org/article/81e1c7f5b98b446aa9e1bbfe57baef27
Publikováno v:
Robotics, Vol 12, Iss 1, p 26 (2023)
While several lower-limb exoskeletons have been designed for adult patients, there remains a lack of pediatric-oriented devices. This paper presented a human factor assessment of an adjustable pediatric lower-limb exoskeleton for childhood gait assis
Externí odkaz:
https://doaj.org/article/c20e862feb5c4e0380c582b18e6d6304
Autor:
Hsiang-Chun Chang, Jason Solomon Shapiro, Xinghang Jiang, Grant Senyei, Teruki Sato, Justin Geier, Konrad T Sawicki, Hossein Ardehali
Publikováno v:
eLife, Vol 10 (2021)
Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein im
Externí odkaz:
https://doaj.org/article/09ea966f91184bedb8ce060eab6be3c0
Publikováno v:
Bioengineering, Vol 9, Iss 5, p 208 (2022)
Exoskeleton technology has undergone significant developments for the adult population but is still lacking for the pediatric population. This paper presents the design of a hip–knee exoskeleton for children 6 to 11 years old with gait abnormalitie
Externí odkaz:
https://doaj.org/article/8fc022d472c649e4aec65f3addef39fa
Autor:
Hsiang‐Chun Chang, Rongxue Wu, Meng Shang, Tatsuya Sato, Chunlei Chen, Jason S Shapiro, Ting Liu, Anita Thakur, Konrad T Sawicki, Sathyamangla VN Prasad, Hossein Ardehali
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 3, Pp 247-267 (2016)
Abstract Excess cellular iron increases reactive oxygen species (ROS) production and causes cellular damage. Mitochondria are the major site of iron metabolism and ROS production; however, few studies have investigated the role of mitochondrial iron
Externí odkaz:
https://doaj.org/article/e6b2dfb41f894ce0b3d39c6f95f0a18b
Publikováno v:
Actuators, Vol 9, Iss 4, p 138 (2020)
Lower-limb exoskeletons have undergone significant developments for aiding in the ambulation of adults with gait impairment. However, advancements in exoskeletons for the pediatric population have comparatively been lacking. This paper presents a new
Externí odkaz:
https://doaj.org/article/9ca1f8440b7044428785132ef55e44c6
Autor:
Jerzy T. Sawicki, T. V. V. L. N. Rao
Publikováno v:
International Journal of Rotating Machinery, Vol 10, Iss 3, Pp 227-232 (2004)
A computational procedure for the mechanism of shear between the liquid sublayer and air cavity in the cavitation zone of a submerged journal bearing is presented here. Using the mass conservation principle, Elrod's universal equation is modified to
Externí odkaz:
https://doaj.org/article/18998846e40b4b2084ad1d693cf1cff2