Zobrazeno 1 - 7
of 7
pro vyhledávání: '"P. T. Kotzbauer"'
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to amplify Asyn fibrils extracted from
Externí odkaz:
https://doaj.org/article/34678621ec164ec7a36f533a9c6f2b2a
Autor:
Rebecca L. Miller, Dhruva D. Dhavale, Jennifer Y. O’Shea, Kristin M. Andruska, Jialu Liu, Erin E. Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin, Nigel J. Cairns, Meghan C. Campbell, Joel S. Perlmutter, Paul T. Kotzbauer
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 2, Pp 106-121 (2022)
Abstract Objective Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develo
Externí odkaz:
https://doaj.org/article/5d4c609a4ab746119c1a7b2d88db2bf2
Autor:
Devika P Bagchi, Lihai Yu, Joel S Perlmutter, Jinbin Xu, Robert H Mach, Zhude Tu, Paul T Kotzbauer
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55031 (2013)
Accumulation of α-synuclein (α-syn) fibrils in Lewy bodies and Lewy neurites is the pathological hallmark of Parkinson disease (PD). Ligands that bind α-syn fibrils could be utilized as imaging agents to improve the diagnosis of PD and to monitor
Externí odkaz:
https://doaj.org/article/3dc49713006942b79b9bdd0d8d29ae74
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12897 (2010)
Mutations in the PLA2G6 gene have been identified in autosomal recessive neurodegenerative diseases classified as infantile neuroaxonal dystrophy (INAD), neurodegeneration with brain iron accumulation (NBIA), and dystonia-parkinsonism. These clinical
Externí odkaz:
https://doaj.org/article/db7420b899604e6da3ff7bc4000feadf
Autor:
J P, Golden, R H, Baloh, P T, Kotzbauer, P A, Lampe, P A, Osborne, J, Milbrandt, E M, Johnson
Publikováno v:
The Journal of comparative neurology. 398(1)
Neurturin (NTN) and glial cell line-derived neurotrophic factor (GDNF) are the first two members of the GDNF family (GF) of neurotrophic factors. These two proteins are potent survival factors for several populations of central and peripheral neurons
Autor:
Wenhua Chu, Dong Zhou, Vrinda Gaba, Jialu Liu, Shihong Li, Xin Peng, Jinbin Xu, Dhruva Dhavale, DevikaP. Bagchi, André d’Avignon, Naomi B. Shakerdge, Brian J. Bacskai, Zhude Tu, Paul T. Kotzbauer, Robert H. Mach
Publikováno v:
Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 15, p6002-6017, 16p
Publikováno v:
Molecular and Cellular Biology. 9:3166-3173
Hemin-induced differentiation of the human erythroleukemia cell line K562 results in the expression and accumulation of erythroid-specific gene products such as embryonic and fetal hemoglobins and the elevated synthesis of the major heat shock protei