Zobrazeno 1 - 10 of 60 pro vyhledávání: '"P. T. A. Schellekens"'
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Treatment of acute kidney allograft rejection with a non-mitogenic CD3 antibody
Autor: I. J. M. Ten Berge, S. L. Yong, S. Surachno, F. J. Bemelman, R. T. Meijer, S. Florquin, P. T. A. Schellekens
Publikováno v: Clinical and experimental immunology, 133(3), 485-492. Wiley-Blackwell
SUMMARYT3/4.A is a non-mitogenic murine IgA mAb to human CD3 that was selected for clinical studies to provide an alternative for the mitogenic, T cell-activating, therapeutic mAb OKT3. Previously, we reported that T3/4.A is better tolerated in human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13649a80a9237fa35e8336105e2cbe74
https://doi.org/10.1046/j.1365-2249.2003.02200.x
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3
Pharmacokinetics of Murine Anti-Human CD3 Antibodies in Man Are Determined by the Disappearance of Target Antigen
Autor: I. J. M. Ten Berge, R. T. Meijer, Richard P. Koopmans, P. T. A. Schellekens
Publikováno v: Journal of pharmacology and experimental therapeutics, 300(1), 346-353. American Society for Pharmacology and Experimental Therapeutics
Therapy with monoclonal antibodies (mAbs) is characterized by a molar ratio of receptor to drug that is higher than usual in pharmacotherapy. As a consequence, changes in the amount of receptors induced by the therapy may have important consequences
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af93911a0c8709cdf8fcab4d182c3c2
https://doi.org/10.1124/jpet.300.1.346
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4
Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation
Autor: S. L. Yong, P. T. A. Schellekens, I. J. M. Ten Berge, R. A. W. Van Lier, R. T. Meijer
Publikováno v: Clinical and experimental immunology, 123(3), 511-519. Wiley-Blackwell
SummaryCLB T3/4.A is a non FcR-binding CD3 mAb of the murine IgA isotype, which may be used as an alternative for the mitogenic OKT3 mAb in the treatment of acute cellular rejection after organ transplantation. We studied TCR signalling and T cell ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f994bc32729dafab03582c2d06adca72
https://doi.org/10.1046/j.1365-2249.2001.01464.x
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5
Expression of Granzyme B during Primary Cytomegalovirus Infection after Renal Transplantation
Autor: P. M. E. Wertheim, P. T. A. Schellekens, I. J. M. Ten Berge, J. Surachno, Angela M. Wolbink, Cornelis E. Hack, Peter C. Wever, L. H. A. Spaeny, H. J. J. Van Der Vliet, R.J Rentenaar
Publikováno v: The Journal of Infectious Diseases, 179, 693-696. Oxford University Press
Journal of infectious diseases, 179(3), 693-696. Oxford University Press
Wever, P C, Spaeny, L H, van der Vliet, H J, Rentenaar, R J, Wolbink, A M, Surachno, J, Wertheim, P M, Schellekens, P T, Hack, C E & ten Berge, I J 1999, ' Expression of granzyme B during primary cytomegalovirus infection after renal transplantation ', Journal of Infectious Diseases, vol. 179, no. 3, pp. 693-6 . https://doi.org/10.1086/314629
Journal of Infectious Diseases, 179(3), 693-6. Oxford University Press
CD8+ T cells employ granzyme B (GrB) to induce apoptosis in target cells. Increased expression of GrB has been put forward as a diagnostic marker in transplant rejection and viral infection. Three-color flow cytometric analysis revealed that peripher
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cd644e548e542702a4425eb33dd722
https://doi.org/10.1086/314629
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6
Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
Autor: C. H. Fox, Hetty Blaak, van R.P. Rij, de F. Wolf, J. M. A. Lange, Hanneke Schuitemaker, van R.M.E. Praag, ten R.J.M. Berge, Suzanne Jurriaans, P. T. A. Schellekens, Marijke T. L. Roos, Jaap Goudsmit, S.L. Yong, Jan M. Prins
Publikováno v: AIDS (London, England), 13(17), 2405-2410. Lippincott Williams and Wilkins
Background A stable reservoir of latently infected, resting CD4 T cells has been demonstrated in HIV-1-infected patients despite prolonged antiretroviral treatment. This is a major barrier for the eradication of HIV by antiretroviral agents alone. Ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8c17b208e94332c6612863f897baa8
https://doi.org/10.1097/00002030-199912030-00012
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7
Immune restoration does not invariably occur following long term HIV-1 suppression during antiretroviral therapy
Autor: Herman G. Sprenger, P. T. A. Schellekens, Frank P. Kroon, David A. Hall, F. W. Wit, Jsg Montaner, Frank Miedema, Peter Reiss, Eugene Kroon, J. M. A. Lange, Dörte Hamann, R.H. Kauffmann, Marijke T. L. Roos, C. H. H. ten Napel, Peter P. Koopmans, H. M. Weigel, M. E. Van Der Ende, S.J. Otto, F. A. P. Claessen, Nadine Pakker
Publikováno v: Aids, 13, 203-212
Aids, 13, pp. 203-212
Background: Current antiretroviral treatment can induce significant and sustained virological and immunological responses in HIV-1-infected persons over at least the short- to mid-term. Objectives: In this study, long-term immune reconstitution was i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f5e991386246398438bc3b10735e23
https://hdl.handle.net/2066/160339
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8
AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function
Autor: R. A. Coutinho, F. De Wolf, Frank Miedema, Jaap Goudsmit, Ingrid J B Spijkerman, Marijke T. L. Roos, Miranda W. Langendam, C L Kuiken, P. T. A. Schellekens, Marleen Bakker
Publikováno v: AIDS (London, England), 11(15), 1799-1806. Lippincott Williams and Wilkins
Objective: HIV-1 RNA levels in peripheral blood are strongly associated with progression to AIDS, CD4+ T-cell decline, or death. Their predictive value is reportedly independent of the predictive value of CD4+ T-cell counts. Because the interrelation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea65efa5a8ffe84a3a5162a0df80664
https://doi.org/10.1097/00002030-199715000-00003
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9
Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: correlation with decreased CD28 expression
Autor: P. T. A. Schellekens, Marijke T. L. Roos, N. A. S. M. De Leeuw, R. A. Coutinho, J. M. A. Lange, Frank Miedema, Nadine Pakker, A. A. P. Meinesz
Publikováno v: Clinical and experimental immunology, 105(3), 409-415. Wiley-Blackwell
In 219 HIV-1-infected men of the Amsterdam cohort we measured CD4+ T cell numbers and in vitro T cell responses to CD3 MoAbs with or without CD28 costimulation and phytohaemagglutinin (PHA). The value of these markers was estimated for disease progre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da850ac14d91f26dafddfef38671a66
https://doi.org/10.1046/j.1365-2249.1996.d01-794.x
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10
Viro-immunological studies in acute HIV-1 infection
Autor: Frank Miedema, F. A. P. Claessen, Neeltje A. Kootstra, L. Meyaard, Hanneke Schuitemaker, N. A. S. M. De Leeuw, H. G. Huisman, Marijke T. L. Roos, P. T. A. Schellekens
Publikováno v: AIDS (London, England), 8(11), 1533-1538. Lippincott Williams and Wilkins
Scopus-Elsevier
Objective To monitor a patient who presented with symptomatic HIV-1 infection for virological and immunological parameters in relation to the clinical course. Methods Virological studies included determination of frequency of productively HIV-1-infec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20186319985b9649ecfab3ef44fe57
https://doi.org/10.1097/00002030-199411000-00003
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