Zobrazeno 1 - 10
of 236
pro vyhledávání: '"P. Szlosarek"'
Autor:
Kristina Navickaitė, Stefan Langenhan, Jenny Köckritz, Anastasiia Sherstneva, Klaus Nestler, Michael Penzel, Marco Wendler, Robert Szlosarek, Michael Hauser, Olena Volkova, Matthias Kröger, Henning Zeidler
Publikováno v:
Results in Surfaces and Interfaces, Vol 17, Iss , Pp 100288- (2024)
Three different modes of plasma electrolytic polishing (PEP) of additively manufactured high-alloy austenitic steel specimens, which were fabricated using a powder bed fusion electron beam (PBF-EB/M) technology, were investigated in this study. Namel
Externí odkaz:
https://doaj.org/article/0ed26e0c50884f5194388fe490478c2b
Akademický článek
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Publikováno v:
Lung Cancer: Targets and Therapy, Vol Volume 13, Pp 53-66 (2022)
Joséphine Carpentier,1 Iuliia Pavlyk,1 Uma Mukherjee,2 Peter E Hall,2 Peter W Szlosarek1,2 1Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK; 2Department of Medical Oncol
Externí odkaz:
https://doaj.org/article/c409671b94c34c679f64974823707674
Publikováno v:
BMC Rheumatology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract Background Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with an overall poor prognosis. In October 2020, first line treatment with the PD-1 antagonist nivolumab and the CTLA-4 antagonist ipilimumab for unresectable di
Externí odkaz:
https://doaj.org/article/39ebde09f92c48369e8299729636f1cb
Akademický článek
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Autor:
Peter W. Szlosarek, Akhila G. Wimalasingham, Melissa M. Phillips, Peter E. Hall, Pui Ying Chan, John Conibear, Louise Lim, Sukaina Rashid, Jeremy Steele, Paula Wells, Chiung‐Fang Shiu, Chih‐Ling Kuo, Xiaoxing Feng, Amanda Johnston, John Bomalaski, Stephen Ellis, Marianne Grantham, Michael Sheaff
Publikováno v:
Cancer Medicine, Vol 10, Iss 19, Pp 6642-6652 (2021)
Abstract Introduction We evaluated the arginine‐depleting enzyme pegargiminase (ADI‐PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1‐deficient non‐squamous non‐small cell lung cancer (NSCLC) via a phase 1 dose‐exp
Externí odkaz:
https://doaj.org/article/fabac2ca189a4727aedc6bdbadb5864e
Publikováno v:
Lubricants, Vol 11, Iss 8, p 348 (2023)
The appearance of fretting fatigue cracks in bolted sheets limits their lifetime. Furthermore, repairing these failures requires much effort due to needing to replace the components instead of replacing just the bolt. To prevent such failures, the pu
Externí odkaz:
https://doaj.org/article/f6757568ff454a69a50b6cab660c6deb
Autor:
Teresa A. Szyszko, MD, FRCR, Joel T. Dunn, PhD, Melissa M. Phillips, MD, PhD, John Bomalaski, MD, Michael T. Sheaff, MD, Steve Ellis, MD, Lucy Pike, PhD, Vicky Goh, MD, FRCR, Gary J.R. Cook, MD, FRCR, Peter W. Szlosarek, MD, PhD, FRCP
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100382- (2022)
Introduction: Pegargiminase (ADI-PEG 20I) degrades arginine in patients with argininosuccinate synthetase 1-deficient malignant pleural mesothelioma (MPM) and NSCLC. Imaging with proliferation biomarker 3'-deoxy-3'-[18F] fluorothymidine (18F-FLT) pos
Externí odkaz:
https://doaj.org/article/24b63e146e99419791c4c911d1a9c802
Publikováno v:
African Journal of Emergency Medicine, Vol 11, Iss 1, Pp 175-181 (2021)
Introduction: Due to the COVID-19 crisis or any other mass casualty situation it might be necessary to give artificial ventilation to many affected patients. Contrarily, the worldwide availability of emergency ventilators is still a shortage, especia
Externí odkaz:
https://doaj.org/article/15809e85a4b14f41885f2cf9f1d6a2b0
Publikováno v:
Molecules, Vol 28, Iss 5, p 2150 (2023)
Arginine is a semi-essential amino acid which becomes wholly essential in many cancers commonly due to the functional loss of Argininosuccinate Synthetase 1 (ASS1). As arginine is vital for a plethora of cellular processes, its deprivation provides a
Externí odkaz:
https://doaj.org/article/2c7710c6ff58423fa60b889da8dff902