Zobrazeno 1 - 10
of 31
pro vyhledávání: '"P. Starkey-Lewis"'
Autor:
Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-spec
Externí odkaz:
https://doaj.org/article/9401d867436e46d280e980e296abdf7e
Autor:
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552- (2021)
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In
Externí odkaz:
https://doaj.org/article/0fd0f2e5fb724e438758d7df1a29d1bc
Autor:
Olivia Matthews, Emma E. Morrison, John D. Tranter, Philip Starkey Lewis, Iqbal S. Toor, Abhishek Srivastava, Rebecca Sargeant, Helen Rollison, Kylie P. Matchett, Timothy J. Kendall, Gillian A. Gray, Chris Goldring, Kevin Park, Laura Denby, Neeraj Dhaun, Matthew A. Bailey, Neil C. Henderson, Dominic Williams, James W. Dear
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103092- (2020)
Background: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney. Methods: Dicerflox/flox mic
Externí odkaz:
https://doaj.org/article/6471fb5992d44958b700cf85b5053236
Autor:
Sofia Ferreira-Gonzalez, Wei-Yu Lu, Alexander Raven, Benjamin Dwyer, Tak Yung Man, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Tim J. Kendall, Thomas G. Bird, Nuria Tarrats, Juan-Carlos Acosta, Luke Boulter, Stuart J. Forbes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dep
Externí odkaz:
https://doaj.org/article/fec37437098140028922b5a6d61c5040
Autor:
Sharmin S. Haideri, Alison C. McKinnon, A. Helen Taylor, Phoebe Kirkwood, Philip J. Starkey Lewis, Eoghan O’Duibhir, Bertrand Vernay, Stuart Forbes, Lesley M. Forrester
Publikováno v:
npj Regenerative Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
Stem cell-derived macrophages could treat liver fibrosis Macrophages, a type of white blood cell, when derived from embryonic stem cells in the laboratory reduce fibrosis in chronic liver disease. Lesley Forrester and colleagues from the University o
Externí odkaz:
https://doaj.org/article/aad90fc453e148b789e551de85f93a2f
Autor:
Alwahsh, Salamah M., Qutachi, Omar, Starkey Lewis, Philip J., Bond, Andrew, Noble, June, Burgoyne, Paul, Morton, Nik, Carter, Rod, Mann, Janet, Ferreira-Gonzalez, Sofia, Alvarez-Paino, Marta, Forbes, Stuart J., Shakesheff, Kevin M., Forbes, Shareen
Publikováno v:
American journal of transplantation; September 2021, Vol. 21 Issue: 9 p2950-2963, 14p
Autor:
R, Eakins, J, Walsh, L, Randle, R E, Jenkins, I, Schuppe-Koistinen, C, Rowe, P, Starkey Lewis, O, Vasieva, N, Prats, N, Brillant, M, Auli, M, Bayliss, S, Webb, J A, Rees, N R, Kitteringham, C E, Goldring, B K, Park
Publikováno v:
Scientific Reports
Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10–15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal models results in autoprotection. Insight of this process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d876a06d9e5abf16c32c412a183130b0
https://pubmed.ncbi.nlm.nih.gov/26607827
https://pubmed.ncbi.nlm.nih.gov/26607827
Autor:
Watanabe, Yusuke, Tsuchiya, Atsunori, Seino, Satoshi, Kawata, Yuzo, Kojima, Yuichi, Ikarashi, Shunzo, Starkey Lewis, Philip J., Lu, Wei‐Yu, Kikuta, Junichi, Kawai, Hirokazu, Yamagiwa, Satoshi, Forbes, Stuart J., Ishii, Masaru, Terai, Shuji
Publikováno v:
Stem Cells Translational Medicine; March 2019, Vol. 8 Issue: 3 p271-284, 14p
Autor:
P. Starkey-Lewis, V. Platt, J. Coyle, Christopher E. Goldring, David J. Webb, R.H. Thanacoody, J.G. Moggs, Alasdair Gray, M. Masson, D. N. Bateman, Daniel J. Antoine, James W. Dear, B.K. Park
Publikováno v:
Journal of Hepatology. 58:S211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f096f256f8e2532ca1a4e7d54781d3b
https://doi.org/10.1016/s0168-8278(13)60517-6
https://doi.org/10.1016/s0168-8278(13)60517-6
Autor:
Thulin, Petra, Hornby, Robert J., Auli, Mariona, Nordahl, Gunnar, Antoine, Daniel J., Starkey Lewis, Philip, Goldring, Christopher E., Park, B. Kevin, Prats, Neus, Glinghammar, Björn, Schuppe-Koistinen, Ina
Publikováno v:
Biomarkers; July 2017, Vol. 22 Issue: 5 p461-469, 9p