Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P. S. Widdowson"'
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated. Recently
Externí odkaz:
https://doaj.org/article/3dc35049029a4d4584e603c56bffa30e
Publikováno v:
Pharmaceuticals, Vol 3, Iss 6, Pp 1842-1872 (2010)
Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patien
Externí odkaz:
https://doaj.org/article/32a9b9c9df10438ab25a5298d558f3b7
Publikováno v:
Journal of Neurochemistry. 64:651-661
Binding of [ 3 H]glutamate, [ 3 H]glycine, and the glutamate antagonist [ 3 H] CGS-19755 to NMDA-type glutamate receptors was examined in homogenates of rat forebrain and cerebellum. Most glutamate agonists had a higher affinity at the [ 3 H]glutamat
Autor:
R. Chatfield, M. C. T. Fyfe, J. R. White, A. Taylor, E. Wargent, Richard L. Printz, T. Sulpice, J. G. McCormack, C. Reynet, P. Wong-Kai-In, P. S. Widdowson, M. J. Procter
Publikováno v:
Diabetologia. 50(6)
We evaluated the insulinotropic and antihyperglycaemic actions of glucokinase activators (GKAs), especially through acute and subchronic studies in rodent diabetes models with (2R)-2-(4-cyclopropanesulphonylphenyl)-N-(5-fluorothiazol-2-yl)-3-(tetrahy
Autor:
P S, Widdowson, J P, Wilding
Publikováno v:
Frontiers of hormone research. 26
Publikováno v:
British journal of pharmacology. 128(7)
1. The blood glucose-lowering efficacy of rosiglitazone (RSG) and the mechanisms of associated weight gain were determined in dietary obese rats (DIOs). DIO and chow-fed rats received RSG 0.3-30 mg kg-1 daily for 21 days. 2. In DIOs, plasma glucose a
Publikováno v:
British journal of pharmacology. 125(8)
1. We examined the effect of chronic (21 days) oral treatment with the thiazolidinedione, MCC-555 ((+)-5-[[6-(2-fluorbenzyl)-oxy-2-naphy]methyl]-2,4-thiazo lid inedione) on metabolic status and insulin sensitivity in obese (fa/fa) Zucker rats and Zuc
Publikováno v:
Neurotoxicology. 18(1)
L-2-Chloropropionic acid (L-CPA), when orally administered at single high dose to rats produces a selective lesion in the cerebellum involving destruction of a high proportion of granule cells by a mechanism which involves N-methyl-D-aspartate (NMDA)
Publikováno v:
Neurotoxicology. 17(2)
The agrochemical intermediate, L-2-Chloropropionic acid (L-2-CPA) and D-2-chloropropionic acid (D-CPA), when administered separately by oral gavage to rats, produced extensive cerebellar granule cell necrosis (80%) characterised by varying degrees of
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(3)
In the present study, we examined the binding of the alpha-2 adrenergic receptor (AR) antagonist [3H]-(2-(2-methoxy-1,4-benzodioxan- 2yl)-2-imidazoline ([3H]RX821002) to alpha-2 AR in rat cerebral cortex (CC) and compared the properties of these site