Zobrazeno 1 - 10
of 35
pro vyhledávání: '"P. S. Heeger"'
Autor:
Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun, Helen S. Goodridge
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neur
Externí odkaz:
https://doaj.org/article/ea800acc967149ce81f4777b84b82d93
Autor:
Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. Peled, Israel Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao-Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTThe present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population expe
Externí odkaz:
https://doaj.org/article/35f57b6f47564d71a10ebcf40edbc4b6
Autor:
Zeguo Sun, Zhongyang Zhang, Khadija Banu, Ian W. Gibson, Robert B. Colvin, Zhengzi Yi, Weijia Zhang, Bony De Kumar, Anand Reghuvaran, John Pell, Thomas D. Manes, Arjang Djamali, Lorenzo Gallon, Philip J. O’Connell, John Cijiang He, Jordan S. Pober, Peter S. Heeger, Madhav C. Menon
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Donor-recipient (D-R) mismatches outside of human leukocyte antigens (HLAs) contribute to kidney allograft loss, but the mechanisms remain unclear, specifically for intronic mismatches. We quantified non-HLA mismatches at variant-, gene-, and genome-
Externí odkaz:
https://doaj.org/article/1062a57a1df84d2eb0cec1a6f8b62c10
Autor:
Sofia Bin, Chiara Cantarelli, Julian K. Horwitz, Micaela Gentile, Manuel Alfredo Podestà, Gaetano La Manna, Peter S. Heeger, Paolo Cravedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAdministration of recombinant erythropoietin (EPO), a kidney-produced hormone with erythropoietic functions, has been shown to have multiple immunoregulatory effects in mice and humans, but whether physiological levels of EPO regulate immun
Externí odkaz:
https://doaj.org/article/c8f23f4f142d45d783bbc302d4349977
Autor:
Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune modulation, but EPO’s effects in transplantation remain incompletely understood. We tested the mechanisms linking EPO administration to prolongation of murine heterotop
Externí odkaz:
https://doaj.org/article/1b0271f84e3245dda23663c661913691
Autor:
Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich, Stephen R. Salton
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate wi
Externí odkaz:
https://doaj.org/article/20d91e074df844c7b5db2558788c3e2f
Autor:
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate a
Externí odkaz:
https://doaj.org/article/1cef15809b5044ec872dc4819293a566
Autor:
Ilaria Gandolfini, Cynthia Harris, Michael Abecassis, Lisa Anderson, Oriol Bestard, Giorgia Comai, Paolo Cravedi, Elena Cremaschi, J. Andrew Duty, Sander Florman, John Friedewald, Gaetano La Manna, Umberto Maggiore, Thomas Moran, Giovanni Piotti, Carolina Purroy, Marta Jarque, Vinay Nair, Ron Shapiro, Jessica Reid-Adam, Peter S. Heeger
Publikováno v:
Kidney International Reports, Vol 2, Iss 6, Pp 1186-1193 (2017)
Measuring the chemokine CXCL9 in urine by enzyme-linked immunosorbent assay (ELISA) can diagnose acute cellular rejection (ACR) noninvasively after kidney transplantation, but the required 12- to 24-hour turnaround time is not ideal for rapid, clinic
Externí odkaz:
https://doaj.org/article/09db3cad74214f0da2b0b9d9ee892fcd
Autor:
Nicholas Chun, Ala S Haddadin, Junying Liu, Yunfang Hou, Karen A Wong, Daniel Lee, Julie I Rushbrook, Karan Gulaya, Roberta Hines, Tamika Hollis, Beatriz Nistal Nuno, Abeel A Mangi, Sabet Hashim, Marcela Pekna, Amy Catalfamo, Hsiao-Ying Chin, Foramben Patel, Sravani Rayala, Ketan Shevde, Peter S Heeger, Ming Zhang
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179450 (2017)
The pathophysiology of myocardial injury that results from cardiac ischemia and reperfusion (I/R) is incompletely understood. Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the cla
Externí odkaz:
https://doaj.org/article/f9de289149d747c78f526e23e00a728d
Autor:
Lily Li, Marvin Lin, Maria Krassilnikova, Katya Ostrow, Amanda Bader, Brian Radbill, Jaime Uribarri, Joji Tokita, Staci Leisman, Vijay Lapsia, Randy A Albrecht, Adolfo García-Sastre, Andrea D Branch, Peter S Heeger, Anita Mehrotra
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109998 (2014)
Memory T-cells are mediators of transplant injury, and no therapy is known to prevent the development of cross-reactive memory alloimmunity. Activated vitamin D is immunomodulatory, and vitamin D deficiency, common in hemodialysis patients awaiting t
Externí odkaz:
https://doaj.org/article/bc2751fa3ff84d54a8fc16347054d413