General expectation of partitional moment functions

Autor: D. S. Tracy, P. S. Dwyer

Publikováno v: Revista Técnica de la Facultad de Ingeniería, Vol 3, Iss 2 (2011)

The paper provides a general theory for expected values of linear functions of products of sample power sums in terms of products of population power sums -all given symbolically by partitions. This approach is so general that the results can be appl

Externí odkaz: https://doaj.org/article/72f5d3ed7cba44378dba85b7af872501

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Autor: Tiffany S. Dwyer, Joseph B. O’Brien, Christopher P. Ptak, Justin E. LaVigne, Daniel P. Flaherty, Val J. Watts, David L. Roman

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction

Externí odkaz: https://doaj.org/article/4793afb3dd74437f826c2afee224beed

Protein Receptors Evolved from Homologous Cohesion Modules That Self-Associated and Are Encoded by Interactive Networked Genes

Autor: Donard S. Dwyer

Publikováno v: Life, Vol 11, Iss 12, p 1335 (2021)

Previously, it was proposed that protein receptors evolved from self-binding peptides that were encoded by self-interacting gene segments (inverted repeats) widely dispersed in the genome. In addition, self-association of the peptides was thought to

Externí odkaz: https://doaj.org/article/b3f66a0a4b37446cb6ac87ed1984141b

Detection of Lubrication State in a Field Operational Wind Turbine Gearbox Bearing Using Ultrasonic Reflectometry

Autor: G. Nicholas, B. P. Clarke, R. S. Dwyer-Joyce

Publikováno v: Lubricants, Vol 9, Iss 1, p 6 (2021)

Fully flooded lubrication is the ideal state for a rolling bearing; this is especially true in the aggressive environment of a wind turbine transmission where bearings are subject to intermittent operation and highly variable loading. In this paper,

Externí odkaz: https://doaj.org/article/1fb001ff2ba84ad58d0e1b99666dffd4

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c