Converging evidence for functional connections between the lithium response and PI3K-Akt signaling

Autor: Donard S. Dwyer

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-3 (2024)

Externí odkaz: https://doaj.org/article/32c527e290b8415cb7fae51ed422ae76

Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants

Autor: Titilade Ajayi, Alicia Thomas, Marko Nikolic, Lauryn Henderson, Alexa Zaheri, Donard S. Dwyer

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

BackgroundGenome wide association studies (GWAS) and candidate gene analyses have identified genetic variants and genes that may increase the risk for suicidal thoughts and behaviors (STBs). Important unresolved issues surround these tentative risk v

Externí odkaz: https://doaj.org/article/505940aed8c64a4cb8a451d7836aff00

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Autor: Tiffany S. Dwyer, Joseph B. O’Brien, Christopher P. Ptak, Justin E. LaVigne, Daniel P. Flaherty, Val J. Watts, David L. Roman

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction

Externí odkaz: https://doaj.org/article/4793afb3dd74437f826c2afee224beed

A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder

Autor: Laura A. Potter, Danielle A. Scholze, Hazel Maridith B. Biag, Andrea Schneider, Yanjun Chen, Danh V. Nguyen, Akash Rajaratnam, Susan M. Rivera, Patrick S. Dwyer, Flora Tassone, Reem R. Al Olaby, Nimrah S. Choudhary, Maria J. Salcedo-Arellano, Randi J. Hagerman

Publikováno v: Frontiers in Psychiatry, Vol 10 (2019)

Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertrali

Externí odkaz: https://doaj.org/article/2ebcac73ae3f4896a8dea6bb1ae3fa36

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c