Zobrazeno 1 - 10
of 30
pro vyhledávání: '"P. S. DeCarli"'
Autor:
Emily Nicole Holy, Elizabeth Li, Anjan Bhattarai, Evan Fletcher, Evelyn R. Alfaro, Danielle J. Harvey, Benjamin A. Spencer, Simon R. Cherry, Charles S. DeCarli, Audrey P. Fan
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Kinetic modeling of 18F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitative PET. The total-b
Externí odkaz:
https://doaj.org/article/3ececbf692bd45db9c93eea02bbbfaa9
Autor:
Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associat
Externí odkaz:
https://doaj.org/article/d9f552a1cc0842fc826edbb499f07475
Autor:
Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, Matthew O. Goodman, Wassim Tarraf, Iris Broce, Richard B. Lipton, Martha Daviglus, Melissa Lamar, Sylvia Wassertheil-Smoller, Jianwen Cai, Charles S. DeCarli, Hector M. Gonzalez, Myriam Fornage
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Introduction Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs in 4,189 diverse Hispanics/Latinos (mean age 63 years) from the Study
Externí odkaz:
https://doaj.org/article/5da6e55d2e374afb98fd4e6a79e57952
Autor:
Mitzi M. Gonzales, Crystal Wiedner, Chen‐Pin Wang, Qianqian Liu, Joshua C. Bis, Zhiguang Li, Jayandra J. Himali, Saptaparni Ghosh, Emy A. Thomas, Danielle M. Parent, Tiffany F. Kautz, Matthew P. Pase, Hugo J. Aparicio, Luc Djoussé, Kenneth J. Mukamal, Bruce M. Psaty, William T. Longstreth Jr, Thomas H. Mosley Jr, Vilmundur Gudnason, Djass Mbangdadji, Oscar L. Lopez, Kristine Yaffe, Stephen Sidney, R. Nick Bryan, Ilya M. Nasrallah, Charles S. DeCarli, Alexa S. Beiser, Lenore J. Launer, Myriam Fornage, Russell P. Tracy, Sudha Seshadri, Claudia L. Satizabal
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 10, Pp 1574-1585 (2022)
Abstract Objective Expression of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytosis, colocalizes with neuropathology in the brain. Blood levels of GFAP have been associated with cognitive decline and dementia status. However, f
Externí odkaz:
https://doaj.org/article/f62e692ace824cb49e09951b82e5f859
Autor:
Chloé Sarnowski, Mohsen Ghanbari, Joshua C. Bis, Mark Logue, Myriam Fornage, Aniket Mishra, Shahzad Ahmad, Alexa S. Beiser, Eric Boerwinkle, Vincent Bouteloup, Vincent Chouraki, L Adrienne Cupples, Vincent Damotte, Charles S. DeCarli, Anita L. DeStefano, Luc Djoussé, Alison E. Fohner, Carol E. Franz, Tiffany F. Kautz, Jean-Charles Lambert, Michael J. Lyons, Thomas H. Mosley, Kenneth J. Mukamal, Matthew P. Pase, Eliana C. Portilla Fernandez, Robert A. Rissman, Claudia L. Satizabal, Ramachandran S. Vasan, Amber Yaqub, Stephanie Debette, Carole Dufouil, Lenore J. Launer, William S. Kremen, William T. Longstreth, M Arfan Ikram, Sudha Seshadri
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A meta-analysis of genome-wide association studies of circulating total-tau levels identifies loci specific to European or African American ancestries, providing further insight to the genetic etiology of neurological diseases.
Externí odkaz:
https://doaj.org/article/11775a823f8a4d75857525f107783c4d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased Abeta and amyloid plaques. Increa
Externí odkaz:
https://doaj.org/article/427b975ae14b4e37bc769ac1ad4a858e
Autor:
Robert Joseph Thomas, Hyun Kim, Pauline Maillard, Charles S. DeCarli, Eric James Heckman, Cody Karjadi, Ting Fang Alvin Ang, Rhoda Au
Publikováno v:
Exploration of Medicine, Vol 2, Iss 3, Pp 253-267 (2021)
Aim:Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Methods:The target population was the Framingham Heart
Externí odkaz:
https://doaj.org/article/f134c7e619d549a69afff2c22b950bcf
Autor:
Emer R. McGrath, Jayandra J. Himali, Daniel Levy, Sarah C. Conner, Charles S. DeCarli, Matthew P. Pase, Paul Courchesne, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1659-1670 (2019)
Abstract Objective To determine the association between plasma insulin‐like growth factor binding protein 2 (IGFBP‐2) and cognitive outcomes. Methods We measured plasma IGFBP‐2 levels in 1596 (53% women, mean age 68.7 [SD 5.7] years) dementia
Externí odkaz:
https://doaj.org/article/ecfae2091cc54802a51fff138e30c451
Autor:
Brian V. Hong, Jingyuan Zheng, Joanne K. Agus, Xinyu Tang, Carlito B. Lebrilla, Lee-Way Jin, Izumi Maezawa, Kelsey Erickson, Danielle J. Harvey, Charles S. DeCarli, Dan M. Mungas, John M. Olichney, Sarah T. Farias, Angela M. Zivkovic
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1495 (2022)
High-density lipoproteins (HDL) play a critical role in cholesterol homeostasis. Apolipoprotein E (APOE), particularly the E4 allele, is a significant risk factor for Alzheimer’s disease but is also a key HDL-associated protein involved in lipid tr
Externí odkaz:
https://doaj.org/article/325e6bccc74b4c3abd3773d927e34f85
Autor:
Mohamed Salah Khlif, Natalia Egorova, Emilio Werden, Alberto Redolfi, Marina Boccardi, Charles S. DeCarli, Evan Fletcher, Baljeet Singh, Qi Li, Laura Bird, Amy Brodtmann
Publikováno v:
NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)
Manual quantification of the hippocampal atrophy state and rate is time consuming and prone to poor reproducibility, even when performed by neuroanatomical experts. The automation of hippocampal segmentation has been investigated in normal aging, epi
Externí odkaz:
https://doaj.org/article/e996edf564dc4ccfb146cae6b68fcbbd