Zobrazeno 1 - 10
of 39
pro vyhledávání: '"P. S. Blackburn"'
Publikováno v:
Natural Hazards and Earth System Sciences, Vol 24, Pp 2633-2646 (2024)
What's the worst that could happen? After a flood has devastated communities, those affected, the news media, and the authorities often say that what happened was beyond our imagination. Imagination encompasses the picturing of a situation in our min
Externí odkaz:
https://doaj.org/article/7e7032d0f9eb44e9a3cfdf9343166d00
Autor:
Gwylim S. Blackburn, Christopher I. Keeling, Julien Prunier, Melody A. Keena, Catherine Béliveau, Richard Hamelin, Nathan P. Havill, Francois Olivier Hebert, Roger C. Levesque, Michel Cusson, Ilga Porth
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Flight can drastically enhance dispersal capacity and is a key trait defining the potential of exotic insect species to spread and invade new habitats. The phytophagous European spongy moths (ESM, Lymantria dispar dispar) and Asia
Externí odkaz:
https://doaj.org/article/393b79dbc8e9412eadbd94168be31af5
Autor:
Majd A. Al-Hamaly, Anna H. Cox, Meghan G. Haney, Wen Zhang, Emma C. Arvin, Shilpa Sampathi, Mary Wimsett, Chunming Liu, Jessica S. Blackburn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116013- (2024)
The Wnt/β-catenin pathway’s significance in cancer initiation, progression, and stem cell biology underscores its therapeutic potential. However, the clinical application of Wnt inhibitors remains limited due to challenges posed by off-target effe
Externí odkaz:
https://doaj.org/article/76fc5271105e42f49d337f2c63f21788
Autor:
Caroline N Smith, Kyle Kihn, Zachary A Williamson, K Martin Chow, Louis B Hersh, Konstantin V Korotkov, Daniel Deredge, Jessica S Blackburn
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285964 (2023)
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3's oncogenic functions are not well understood, partly due to a lack of research tools available to study this protein. W
Externí odkaz:
https://doaj.org/article/f688ec8b8a0a4c2b94b6ee1357dbd491
Autor:
Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL in
Externí odkaz:
https://doaj.org/article/88b631c58e034e68bd52d1b457e89b2d
Autor:
Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors of
Externí odkaz:
https://doaj.org/article/89ae12dcbcca49f7a9c1ef19ce93ee16
Autor:
A. Deodhar, V. Strand, P. G. Conaghan, E. Sullivan, S. Blackburn, H. Tian, K. Gandhi, S. M. Jugl, R. Alten
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-11 (2020)
Abstract Background Symptoms and comorbidities of ankylosing spondylitis (AS) considerably reduce health-related quality of life (HRQoL) and ability to work. This real-world study assessed rates of tumour necrosis factor inhibitor (TNFi) use and swit
Externí odkaz:
https://doaj.org/article/3bce0e9a1ae94ba2a76bd709465498b3
Autor:
Majd A. Al-Hamaly, Logan T. Turner, Angelica Rivera-Martinez, Analiz Rodriguez, Jessica S. Blackburn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2288 (2023)
The increasing number of available anti-cancer drugs presents a challenge for oncologists, who must choose the most effective treatment for the patient. Precision cancer medicine relies on matching a drug with a tumor’s molecular profile to optimiz
Externí odkaz:
https://doaj.org/article/f2ac221545b54bb8a0658d7d9e2d81f0
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100433- (2021)
Summary: Dysregulation of Wnt signaling is a hallmark of many cancers, and the development of effective, non-toxic small-molecule Wnt inhibitors is desirable. Off-target toxicities of new compounds are typically tested in mouse models, which is both
Externí odkaz:
https://doaj.org/article/ecc3192cb4924fb59bad8e553b0e444e
Publikováno v:
ACS Omega, Vol 4, Iss 3, Pp 4936-4942 (2019)
Externí odkaz:
https://doaj.org/article/919a25e4cd5d424191bd39c351c00c93