Zobrazeno 1 - 10
of 172
pro vyhledávání: '"P. Rissone"'
DNA hybridization is a fundamental reaction with wide-ranging applications in biotechnology. The nearest-neighbor (NN) model provides the most reliable description of the energetics of duplex formation. Most DNA thermodynamics studies have been done
Externí odkaz:
http://arxiv.org/abs/2404.18785
Autor:
Rehman, Azaan, Zhovmer, Alexander, Sato, Ryo, Mukoyama, Yosuke, Chen, Jiji, Rissone, Alberto, Puertollano, Rosa, Vishwasrao, Harshad, Shroff, Hari, Combs, Christian A., Xue, Hui
Deep neural networks have been applied to improve the image quality of fluorescence microscopy imaging. Previous methods are based on convolutional neural networks (CNNs) which generally require more time-consuming training of separate models for eac
Externí odkaz:
http://arxiv.org/abs/2404.04726
RNA's diversity of structures and functions impacts all life forms since primordia. We use calorimetric force spectroscopy to investigate RNA folding landscapes in previously unexplored low-temperature conditions. We find that Watson-Crick RNA hairpi
Externí odkaz:
http://arxiv.org/abs/2403.15352
Autor:
Azaan Rehman, Alexander Zhovmer, Ryo Sato, Yoh-suke Mukouyama, Jiji Chen, Alberto Rissone, Rosa Puertollano, Jiamin Liu, Harshad D. Vishwasrao, Hari Shroff, Christian A. Combs, Hui Xue
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Deep neural networks can improve the quality of fluorescence microscopy images. Previous methods, based on Convolutional Neural Networks (CNNs), require time-consuming training of individual models for each experiment, impairing their applic
Externí odkaz:
https://doaj.org/article/0f066acd3b8344f79e170a1e9cae9366
We review the basic concepts and tools for mechanically unzipping RNA hairpins using force spectroscopy. By pulling apart the ends of an RNA molecule using optical tweezers, it is possible to measure the folding free energy at varying experimental co
Externí odkaz:
http://arxiv.org/abs/2303.14065
The experimental measurement of correlation functions and critical exponents in disordered systems is key to testing renormalization group (RG) predictions. We mechanically unzip single DNA hairpins with optical tweezers, an experimental realization
Externí odkaz:
http://arxiv.org/abs/2210.00777
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms: (1) TMEM55B med
Externí odkaz:
https://doaj.org/article/590b81da36db4b1688e567289596a240
Publikováno v:
PNAS 119 (3), 2022
Accurate knowledge of RNA hybridization is essential for understanding RNA structure and function. Here we mechanically unzip and rezip a 2-kbp RNA hairpin and derive the 10 nearest-neighbor base pair (NNBP) RNA free energies in sodium and magnesium
Externí odkaz:
http://arxiv.org/abs/2201.04992
Publikováno v:
Phys. Rev. Lett. 127, 038001 (2021)
We numerically study the structure of the interactions occurring in three-dimensional systems of hard spheres at jamming, focusing on the large-scale behavior. Given the fundamental role they play in the configuration of jammed packings, we analyze t
Externí odkaz:
http://arxiv.org/abs/2012.10181
Publikováno v:
Journal of Statistical Mechanics: Theory and Experiment 124001 (2019)
The remarkable accuracy and versatility of single-molecule techniques make possible new measurements that are not feasible in bulk assays. Among these, the precise estimation of folding free energies using fluctuation theorems in nonequilibrium pulli
Externí odkaz:
http://arxiv.org/abs/1912.06066