Zobrazeno 1 - 10
of 94
pro vyhledávání: '"P. Rellos"'
Autor:
Christopher J Record, Apirat Chaikuad, Peter Rellos, Sanjan Das, Ashley C W Pike, Oleg Fedorov, Brian D Marsden, Stefan Knapp, Wen Hwa Lee
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11905 (2010)
The serine/threonine mammalian Ste-20 like kinases (MSTs) are key regulators of apoptosis, cellular proliferation as well as polarization. Deregulation of MSTs has been associated with disease progression in prostate and colorectal cancer. The four h
Externí odkaz:
https://doaj.org/article/1cfdc9f60e6b45d2a675287ac891ea71
Autor:
Peter Rellos, Ashley C W Pike, Frank H Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp
Publikováno v:
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
UnlabelledLong-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activa
Externí odkaz:
https://doaj.org/article/0d7234b8593f433581b50ed7155a6727
Autor:
Bliziotis Ioannis A, Rizos Michael, Falagas Matthew E, Rellos Kostas, Kasiakou Sofia K, Michalopoulos Argyris
Publikováno v:
BMC Infectious Diseases, Vol 5, Iss 1, p 1 (2005)
Abstract Background The intravenous use of polymyxins has been considered to be associated with considerable nephrotoxicity and neurotoxicity. For this reason, the systemic administration of polymyxins had been abandoned for about 20 years in most ar
Externí odkaz:
https://doaj.org/article/b8302af7f8b648bab8ab2345fa3fe3bd
Autor:
Ashley C. W. Pike, Stefan Knapp, Frank H. Niesen, P. Rellos, Wen Hwa Lee, Frank von Delft, Eidarus Salah
Publikováno v:
PLoS Biology
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
Structural and biophysical studies reveal how CaMKII kinases, which are important for cellular learning and memory, are switched on by binding of Ca2+/calmodulin.
Long-term potentiation (LTP), a long-lasting enhancement in communication between
Long-term potentiation (LTP), a long-lasting enhancement in communication between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a9096397fc11969fb20dfe52e0ea9a
https://doi.org/10.1371/journal.pbio.1000426
https://doi.org/10.1371/journal.pbio.1000426
Autor:
Sanjan Das, E. Papagrigoriou, Suhyung Cho, Alex N. Bullock, Benjamin E. Turk, Judit É. Debreczeni, Frank H. Niesen, Stefan Knapp, Oleg Fedorov, P. Rellos, Kunde Guo, Gourisankar Ghosh, A. Amos
Publikováno v:
Structure(London, England:1993)
Summary Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kinase (CLK) families. SR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d305980da87e514752b9d16b2163c2
Autor:
Frank H. Niesen, Laurence H. Pearl, Sirlester A. Parker, Antony W. Oliver, Benjamin E. Turk, Ashley C. W. Pike, Stefan Knapp, P. Rellos, Andrew P. Turnbull
Publikováno v:
The EMBO Journal
Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba031f1dffd13a6dfdc63b8e0d8b07b3
https://doi.org/10.1038/emboj.2008.8
https://doi.org/10.1038/emboj.2008.8
Autor:
Michael Sundström, Oleg Fedorov, Stefan Knapp, Brian D. Marsden, P. Rellos, Juerg Schwaller, Vanda Pogacic, Alex N. Bullock, Susanne Müller
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20523-20528
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd279cb5fb05404fe414da9f54e80208
https://doi.org/10.1073/pnas.0708800104
https://doi.org/10.1073/pnas.0708800104
Autor:
Oleg Fedorov, Ashley C. W. Pike, P. Rellos, Stephen J. Smerdon, Frank J. Ivins, Joanne E. Baxter, Donna-Marie Parkinson, Timothy J. Nott, Andrew M. Fry, Sanjan Das, Stefan Knapp, Qi Yu Shen, Steven Howell
Publikováno v:
Journal of Biological Chemistry. 282:6833-6842
The dimeric Ser/Thr kinase Nek2 regulates centrosome cohesion and separation through phosphorylation of structural components of the centrosome, and aberrant regulation of Nek2 activity can lead to aneuploid defects characteristic of cancer cells. Mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dc300dd054e961965c785375c08044
https://doi.org/10.1074/jbc.m609721200
https://doi.org/10.1074/jbc.m609721200
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Publikováno v:
Journal of Medical Genetics. 33:837-841
Hereditary fructose intolerance (HFI) causes severe and sometimes fatal metabolic disturbances in infants and children but responds to dietary treatment. To determine the practicability of screening newborn infants for HFI, we have investigated the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e14a29e30d38720c671fd118be24cf
https://doi.org/10.1136/jmg.33.10.837
https://doi.org/10.1136/jmg.33.10.837