Zobrazeno 1 - 10
of 181
pro vyhledávání: '"P. Racle"'
Publikováno v:
eLife, Vol 13 (2024)
Assay for Transposase-Accessible Chromatin sequencing (ATAC-Seq) is a widely used technique to explore gene regulatory mechanisms. For most ATAC-Seq data from healthy and diseased tissues such as tumors, chromatin accessibility measurement represents
Externí odkaz:
https://doaj.org/article/9712827c651948438aa338f2d4dd65f8
Akademický článek
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Akademický článek
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Autor:
Marthe Solleder, Julien Racle, Philippe Guillaume, George Coukos, Michal Bassani-Sternberg, David Gfeller
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104215- (2022)
Summary: CD4+ T cell activation in infectious diseases and cancer is governed by the recognition of peptides presented on class II human leukocyte antigen (HLA-II) molecules. Therefore, HLA-II ligands represent promising targets for vaccine design an
Externí odkaz:
https://doaj.org/article/c79e975ad73e42688c1d67bbad14a835
Autor:
Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J. Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J. Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-Sternberg, Marco Gerlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Patient derived organoids (PDOs) can be established from colorectal cancers (CRCs) as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomics to investigate neo
Externí odkaz:
https://doaj.org/article/32b7ab7a83d34330933a0f79b7abfe76
Autor:
Kaat de Jonge, Laure Tillé, Joao Lourenco, Hélène Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Grégory Verdeil, Petra Baumgaertner, Daniel E. Speiser
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with an
Externí odkaz:
https://doaj.org/article/00b74b7d42214ef4aec781fbe3b69ef9
Autor:
Sara Bobisse, Raphael Genolet, Annalisa Roberti, Janos L. Tanyi, Julien Racle, Brian J. Stevenson, Christian Iseli, Alexandra Michel, Marie-Aude Le Bitoux, Philippe Guillaume, Julien Schmidt, Valentina Bianchi, Denarda Dangaj, Craig Fenwick, Laurent Derré, Ioannis Xenarios, Olivier Michielin, Pedro Romero, Dimitri S. Monos, Vincent Zoete, David Gfeller, Lana E. Kandalaft, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with
Externí odkaz:
https://doaj.org/article/f208f1e6db6944a78773c68825834778
Autor:
Sara Trabanelli, Mathieu F. Chevalier, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Bérengère Salomé, Mariangela Lecciso, Valentina Salvestrini, Grégory Verdeil, Julien Racle, Cristina Papayannidis, Hideaki Morita, Irene Pizzitola, Camille Grandclément, Perrine Bohner, Elena Bruni, Mukul Girotra, Rani Pallavi, Paolo Falvo, Elisabeth Oppliger Leibundgut, Gabriela M. Baerlocher, Carmelo Carlo-Stella, Daniela Taurino, Armando Santoro, Orietta Spinelli, Alessandro Rambaldi, Emanuela Giarin, Giuseppe Basso, Cristina Tresoldi, Fabio Ciceri, David Gfeller, Cezmi A. Akdis, Luca Mazzarella, Saverio Minucci, Pier Giuseppe Pelicci, Emanuela Marcenaro, Andrew N. J. McKenzie, Dominique Vanhecke, George Coukos, Domenico Mavilio, Antonio Curti, Laurent Derré, Camilla Jandus
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce m
Externí odkaz:
https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9
Akademický článek
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Autor:
Michal Bassani-Sternberg, Antonia Digklia, Florian Huber, Dorothea Wagner, Christine Sempoux, Brian J. Stevenson, Anne-Christine Thierry, Justine Michaux, HuiSong Pak, Julien Racle, Caroline Boudousquie, Klara Balint, George Coukos, David Gfeller, Silvia Martin Lluesma, Alexandre Harari, Nicolas Demartines, Lana E. Kandalaft
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Despite the promising therapeutic effects of immune checkpoint blockade (ICB), most patients with solid tumors treated with anti-PD-1/PD-L1 monotherapy do not achieve objective responses, with most tumor regressions being partial rather than complete
Externí odkaz:
https://doaj.org/article/7a54a5460b79482bb67920b6494b0f01