Zobrazeno 1 - 10
of 131
pro vyhledávání: '"P. R. West"'
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Hao Wu, Samuel R. West
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26891- (2024)
Sites for the construction of wind and solar farms have typically been chosen to maximise total energy generation of an individual site, but rarely consider the intermittency of the renewable resource available at each location. As more renewable gen
Externí odkaz:
https://doaj.org/article/d8e09184fffb448b9b7ba5a428043251
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E Lascano, Xiao Qiang, Jesse R West, L Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/30867674eb6a447eb9255d6b7ddca162
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepatocytes and mononucle
Externí odkaz:
https://doaj.org/article/aeed486998b841e0a8aa558b3197c121
Autor:
Mikita Fuchita, MD, Jack Pattee, PhD, Derek W. Russell, MD, Brian E. Driver, MD, Matthew E. Prekker, MD, MPH, Christopher R. Barnes, MD, Joseph M. Brewer, DO, Kevin C. Doerschug, MD, John P. Gaillard, MD, Sheetal Gandotra, MD, Shekhar Ghamande, MD, Kevin W. Gibbs, MD, Christopher G. Hughes, MD, MS, David R. Janz, MD, MSc, Akram Khan, MD, Steven H. Mitchell, MD, David B. Page, MD, Todd W. Rice, MD, MSc, Wesley H. Self, MD, MPH, Lane M. Smith, MD, PhD, Susan B. Stempek, PA-C, MBA, MMSc, Stacy A. Trent, MD, MPH, Derek J. Vonderhaar, MD, Jason R. West, MD, Micah R. Whitson, MD, Kayla Williamson, MS, Matthew W. Semler, MD, MSc, Jonathan D. Casey, MD, MSc, Adit A. Ginde, MD, MPH, for the Pragmatic Critical Care Research Group
Publikováno v:
Critical Care Explorations, Vol 5, Iss 7, p e0946 (2023)
OBJECTIVE:. Hypotension affects approximately 40% of critically ill patients undergoing emergency intubation and is associated with an increased risk of death. The objective of this study was to examine the association between prophylactic vasopresso
Externí odkaz:
https://doaj.org/article/7464cd657f0947cab643ef8df7743a3c
Autor:
Christopher T. Turner, Megan Pawluk, Juliana Bolsoni, Matthew R. Zeglinski, Yue Shen, Hongyan Zhao, Tatjana Ponomarev, Katlyn C. Richardson, Christopher R. West, Anthony Papp, David J. Granville
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Pressure injuries, also known as pressure ulcers, are regions of localized damage to the skin and/or underlying tissue. Repeated rounds of ischemia–reperfusion (I/R) have a major causative role for tissue damage in pressure injury. Ischemi
Externí odkaz:
https://doaj.org/article/1b5989cb91ee444989ea90fcf5e8b58a
Autor:
Mary P. M. Fossey, Shane J. T. Balthazaar, Jordan W. Squair, Alexandra M. Williams, Malihe-Sadat Poormasjedi-Meibod, Tom E. Nightingale, Erin Erskine, Brian Hayes, Mehdi Ahmadian, Garett S. Jackson, Diana V. Hunter, Katharine D. Currie, Teresa S. M. Tsang, Matthias Walter, Jonathan P. Little, Matt S. Ramer, Andrei V. Krassioukov, Christopher R. West
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
By combining experimental models with prospective clinical studies, the authors show that spinal cord injury causes a rapid reduction in cardiac function that precedes structural changes, and that the loss of descending sympathetic control is the maj
Externí odkaz:
https://doaj.org/article/3046aebaccdc45cdbfc10db7ef4000cf
Autor:
Tuhina Neogi, David J. Hunter, Melvin Churchill, Ivan Shirinsky, Alexander White, Ali Guermazi, Masanari Omata, Robert J. Fountaine, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background A recent phase 3 study demonstrated that treatment with tanezumab, a nerve growth factor inhibitor, or nonsteroidal anti-inflammatory drugs (NSAIDs) improves pain and physical function in participants with moderate-to-severe osteo
Externí odkaz:
https://doaj.org/article/81e12a8d1d7a491790792756213dd7a2
Autor:
Kevin R. Landefeld, MD, Seiji Koike, MAS, Ran Ran, MD, Matthew W. Semler, MD, MSc, Christopher Barnes, MD, Susan B. Stempek, PA-C, MMSc, David R. Janz, MD, MSc, Todd W. Rice, MD, MSc, Derek W. Russell, MD, Wesley H. Self, MD, MPH, Derek Vonderhaar, MD, Jason R. West, MD, Jonathan D. Casey, MD, MSc, Akram Khan, MD, for the Pragmatic Critical Care Research Group, Adit A. Ginde, Sheetal Gandotra, Brian E. Driver, Matthew E. Prekker, Stacy Trent, David R. Janz, Derek W. Russell, Todd W. Rice, Wesley H. Self, Kevin Gibbs
Publikováno v:
Critical Care Explorations, Vol 5, Iss 3, p e0855 (2023)
OBJECTIVES:. Tracheal intubation (TI) is a common procedure in critical care, often performed with a Macintosh curved blade used for direct laryngoscopy (DL). Minimal evidence informs the choice between Macintosh blade sizes during TI. We hypothesize
Externí odkaz:
https://doaj.org/article/d27d5cda0bf9467bbd66d9c6940911fc
Publikováno v:
Communications Physics, Vol 5, Iss 1, Pp 1-10 (2022)
Relaxor ferroelectrics are a type of material exhibiting electrostriction whereby a change in the material shape occurs under an applied electric field; however, although known by the community for many years the underlying mechanisms of the phenomen
Externí odkaz:
https://doaj.org/article/cf18356a342341c181d0a7b6c1fbf215