Zobrazeno 1 - 10
of 367
pro vyhledávání: '"P. R. O'Leary"'
Autor:
Carl G. Streed, Meredith S. Duncan, Kory R. Heier, T. Elizabeth Workman, Lauren B. Beach, Billy A. Caceres, John R. O'Leary, Melissa Skanderson, Joseph L. Goulet
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 22 (2024)
Background Seven million lesbian, gay, and bisexual (LGB) adults will be aged >50 years by 2030; assessing and addressing their risk for cardiovascular disease is critical. Methods and Results We analyzed a nationwide cohort using the Veterans Health
Externí odkaz:
https://doaj.org/article/05ba33faa98b48dbb97d2c3a5f268d49
Autor:
Juan Du, Amanda N. Pope, Brianne R. O’Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract At pharmacological levels, ascorbate (P-AscH-) acts as a pro-oxidant by generating H2O2, depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the role of ATP production by oxidative phosphorylation o
Externí odkaz:
https://doaj.org/article/c43e8748fa3d45c9940de066f4152d51
Autor:
Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Rory S. Carroll, Garett J. Steers, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 361 (2024)
The toxicity of ionizing radiation limits its effectiveness in the treatment of pancreatic ductal adenocarcinoma. Pharmacologic ascorbate (P-AscH−) has been shown to radiosensitize pancreatic cancer cells while simultaneously radioprotecting normal
Externí odkaz:
https://doaj.org/article/d50be425446b432099130382021777a4
Autor:
Francis M Sakita, Sainikitha Prattipati, Jordan Chick, Linda P Samu, Amedeus V Maro, Lauren Coaxum, Sophie W Galson, Dorothy Samuel, Alexander T Limkakeng, Paige R O'Leary, Kajiru G Kilonzo, Nathan M Thielman, Gloria Temu, Julian T Hertz
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285472 (2023)
BackgroundPeople with HIV in sub-Saharan Africa are increasingly developing age-related comorbidities. The purpose of this prospective observational study was to describe 6-month outcomes among Tanzanians with HIV and elevated blood pressure or hyper
Externí odkaz:
https://doaj.org/article/a39e6e84e77d4649bfe5734e9e5e6942
Autor:
Meredith Duncan, Carl G. Streed, Lauren B. Beach, John R. O’Leary, Melissa Skanderson, Joseph L. Goulet
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 10-11 (2023)
OBJECTIVES/GOALS: There is evidence that lesbian, gay, and bisexual (LGB) adults have poorer cardiovascular health than their heterosexual peers, but studies of the association between sexual orientation (SO) and diabetes mellitus (DM) have been few
Externí odkaz:
https://doaj.org/article/52da2aacf42b47b5b31b7cdf583cab07
Autor:
Garett J. Steers, Brianne R. O’Leary, Juan Du, Brett A. Wagner, Rory S. Carroll, Frederick E. Domann, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1683 (2023)
Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverse
Externí odkaz:
https://doaj.org/article/43fcb3ed3d244d5f89e306ce3c3698cf
Autor:
A. Luvai, R. O'Leary, S. Urwin, J. Allen, D. Reay, L. Ingoe, A. Potter, S. Musson, S. Pattman, N. Hopper, C. McAnulty, R.D.G. Neely, P.E. Carey
Publikováno v:
Atherosclerosis Plus, Vol 43, Iss , Pp S8-S9 (2021)
Externí odkaz:
https://doaj.org/article/af1ea93de156486bb310473383f0714a
Autor:
Garett J. Steers, Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Hannah Van Beek, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 971 (2022)
Pancreatic cancer accounts for nearly one fourth of all new cancers worldwide. Little progress in the development of novel or adjuvant therapies has been made over the past few decades and new approaches to the treatment of pancreatic cancer are desp
Externí odkaz:
https://doaj.org/article/1bd5fc59cdc7407fa4643919bfc9d9ac
Autor:
Brianne R. O’Leary, Rory S. Carroll, Garett J. Steers, Jennifer Hrabe, Frederick E. Domann, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1219 (2021)
Reactive oxygen species (ROS) are a normal byproduct of cellular metabolism and are required components in cell signaling and immune responses. However, an imbalance of ROS can lead to oxidative stress in various pathological states. Increases in oxi
Externí odkaz:
https://doaj.org/article/b4da2dbbdbf74167a7b687d5e7c5d355
Autor:
Juan Du, Rory S. Carroll, Garett J. Steers, Brett A. Wagner, Brianne R. O’Leary, Chris S. Jensen, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 614 (2021)
Pancreatic cancer cells (PDACs) are more susceptible to an oxidative insult than normal cells, resulting in greater cytotoxicity upon exposure to agents that increase pro-oxidant levels. Pharmacological ascorbate (P-AscH−), i.e., large amounts give
Externí odkaz:
https://doaj.org/article/5d368059696c4251aebd2719099c0cd8