Zobrazeno 1 - 10
of 57
pro vyhledávání: '"P. R. McGill"'
Autor:
Mitchell R. McGill, Steven C. Curry
Publikováno v:
Livers, Vol 3, Iss 4, Pp 569-596 (2023)
Acetaminophen (APAP) is a widely used drug, but overdose can cause severe acute liver injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly after the development of alanine aminotransferase (ALT) and aspartate ami
Externí odkaz:
https://doaj.org/article/fd6f1526dcb74db6afa1357e04b1b204
Autor:
Mitchell R. McGill, Yihong Kaufmann, Francesca V. LoBianco, Mary A. Schleiff, Nukhet Aykin-Burns, Grover P. Miller
Publikováno v:
Livers, Vol 3, Iss 2, Pp 310-321 (2023)
Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Live
Externí odkaz:
https://doaj.org/article/cb87a53173f0461394b2908ac863a3c6
Autor:
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101808- (2023)
Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic dis
Externí odkaz:
https://doaj.org/article/d6d71cdcd46e41c5bc9d71d91d69be47
Autor:
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 217-229 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, t
Externí odkaz:
https://doaj.org/article/f5788a47b7924c8db7fe23ddaa442896
Autor:
Tessa Plint, Mariel T.I. ten Doeschate, Andrew C. Brownlow, Nicholas J. Davison, Georg Hantke, Andrew C. Kitchener, Fred J. Longstaffe, Rona A. R. McGill, Cornelia Simon-Nutbrown, Clayton R. Magill
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
Dolphins are mobile apex marine predators. Over the past three decades, warm-water adapted dolphin species (short-beaked common and striped) have expanded their ranges northward and become increasingly abundant in British waters. Meanwhile, cold-wate
Externí odkaz:
https://doaj.org/article/3586bd5fab484079847fa47526890a7c
Autor:
Joseph R. McGill, H. A. Daniel Lagassé, Nancy Hernandez, Louis Hopkins, Wojciech Jankowski, Quinn McCormick, Vijaya Simhadri, Basil Golding, Zuben E. Sauna
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-31 (2022)
Abstract The emergence of the novel SARS-CoV-2 virus is the most important public-health issue of our time. Understanding the diverse clinical presentations of the ensuing disease, COVID-19, remains a critical unmet need. Here we present a comprehens
Externí odkaz:
https://doaj.org/article/d202543af6a74be4a9ce962c297fd24c
Autor:
Jerry Xiao, Joseph R. McGill, Apsra Nasir, Alexander Lekan, Bailey Johnson, Devan J. Wilkins, Gray W. Pearson, Kandice Tanner, Hani Goodarzi, Eric Glasgow, Richard Schlegel, Seema Agarwal
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-16 (2022)
Abstract Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer metastasis frequently fail to demonstrate efficacy in clinical trials despite strong preclinical e
Externí odkaz:
https://doaj.org/article/92efc3d65a684014a4ffc01a3f56844d
Autor:
Mitchell R. McGill, Laura P. James, Sandra S. McCullough, Jeffery H. Moran, Samuel E. Mathews, Eric C. Peterson, Davis P. Fleming, Morgan E. Tripod, Joel H. Vazquez, Stefanie Kennon‐McGill, Horace J. Spencer, Jonathan A. Dranoff
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 361-373 (2022)
Current guidelines recommend restricting acetaminophen (APAP) use in patients with cirrhosis, but evidence to support that recommendation is lacking. Prior studies focused on pharmacokinetics (PK) of APAP in cirrhosis but did not rigorously examine c
Externí odkaz:
https://doaj.org/article/2ada1934f2dc4560b741f3c946e06c70
Autor:
Joel H. Vazquez, Mitchell R. McGill
Publikováno v:
Livers, Vol 1, Iss 4, Pp 286-293 (2021)
Circulating biomarkers of drug-induced liver injury (DILI) have been a focus of research in hepatology over the last decade, and several novel DILI biomarkers that hold promise for certain applications have been identified. For example, glutamate deh
Externí odkaz:
https://doaj.org/article/07c24ff1e1794528a84d19cab900abd6
Autor:
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose
Externí odkaz:
https://doaj.org/article/4a3814ab452048b8af9da9c8afc86904