Zobrazeno 1 - 10
of 83
pro vyhledávání: '"P. R. Mahadevan"'
Autor:
Varadha Balaji Venkadakrishnan, Adam G. Presser, Richa Singh, Matthew A. Booker, Nicole A. Traphagen, Kenny Weng, Nathaniel C. E. Voss, Navin R. Mahadevan, Kei Mizuno, Loredana Puca, Osasenaga Idahor, Sheng-Yu Ku, Martin K. Bakht, Ashir A. Borah, Zachary T. Herbert, Michael Y. Tolstorukov, David A. Barbie, David S. Rickman, Myles Brown, Himisha Beltran
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging therapeutic target that is overexpressed in most castration-resistant prostate cancers and implicated as a driver of disease progression and resistance to hormona
Externí odkaz:
https://doaj.org/article/3a09fcc40a5640f5a97df040787fb9ed
Autor:
Yoshihisa Kobayashi, Geoffrey R. Oxnard, Elizabeth F. Cohen, Navin R. Mahadevan, Joao V. Alessi, Yin P. Hung, Arrien A. Bertram, David E. Heppner, Mauricio F. Ribeiro, Karina P. Sacardo, Rodrigo Saddi, Mariana P. Macedo, Rafael B. Blasco, Jiaqi Li, Kari J. Kurppa, Tom Nguyen, Emma Voligny, Guruprasad Ananda, Roberto Chiarle, Artur Katz, Michael Y. Tolstorukov, Lynette M. Sholl, Pasi A. Jänne
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Fusion genes have been proposed as a potential mechanism of resistance to EGFR tyrosine kinase inhibitors (TKIs) in lung cancer. Here, the authors identify gene fusions that are associated with resistance to EGFR TKIs in non-small cell lung cancers,
Externí odkaz:
https://doaj.org/article/0ceddd06c4bb4ffa905cd1128f416204
Autor:
Hsiao-Yun Chen, Yavuz T. Durmaz, Yixiang Li, Amin H. Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G. Doench, Navin R. Mahadevan, Julie-Aurore Losman, David A. Barbie, Michael Y. Tolstorukov, Charles M. Rudin, Triparna Sen, Sabina Signoretti, Matthew G. Oser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
LSD1 inhibition blocks the neuroendocrine phenotype of some small cell lung cancers (SCLCs). Here, a genome-wide CRISPR/Cas9 LSD1 inhibitor resistance screen identifies the mRNA-binding protein ZFP36L1 as a gene repressed by LSD1 that when restored i
Externí odkaz:
https://doaj.org/article/7672bb9231c144b3a01d9383ed50542c
Autor:
Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is
Externí odkaz:
https://doaj.org/article/348d85a40f0943e896d94e5eb485e66c
Autor:
Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon, Sanda Alexandrescu
Publikováno v:
Diagnostic Pathology, Vol 12, Iss 1, Pp 1-6 (2017)
Abstract Background KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions of BRAF with other partner genes, as well as ot
Externí odkaz:
https://doaj.org/article/42de6a8713dd41349f70ad3fb6ba3141
Autor:
Sanjna Nayar, R Mahadevan
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 7, Iss 5, Pp 213-215 (2015)
Digital dental impression is a revolutionary technological advancement that so surpasses the accuracy and efficiency of former techniques for obtaining replicas of prepared teeth for the purpose of fabricating restorations that its adoption by dentis
Externí odkaz:
https://doaj.org/article/f776ec3505e74bf6a19b05f5add84ef8
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 7, Iss 5, Pp 288-290 (2015)
Successful restoration of the dentition requires plenty of contemporary and conventional treatment techniques and planning and attachment retained partial dentures are one such kind of treatment modality in prosthodontics. Satisfactory restoration in
Externí odkaz:
https://doaj.org/article/1d98a995d281429f8b21efd225fdb6ab
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 7, Iss 5, Pp 95-97 (2015)
Many methods have been used to establish the occlusal plane in complete denture prosthodontics. However, no single method seems to be fully accepted. Anteriorly, esthetic considerations help define the occlusal plane, and posteriorly the tongue, retr
Externí odkaz:
https://doaj.org/article/8a36ad238baf46289634fd6d0043c0cd
Publikováno v:
Biogeosciences, Vol 9, Iss 3, Pp 1033-1040 (2012)
Enhancing microbial U(VI) reduction with the addition of organic electron donors is a promising strategy for immobilizing uranium in contaminated groundwaters, but has yet to be optimized because of a poor understanding of the factors controlling the
Externí odkaz:
https://doaj.org/article/85afc3f2364e45f69fe2491c26879f41
Publikováno v:
Journal of Inflammation Research, Vol 2010, Iss default, Pp 99-103 (2010)
Navin R Mahadevan, Antonio Fernandez, Jeffrey J Rodvold, Gonzalo Almanza, Maurizio ZanettiThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, USABackground: Several micro-environmental a
Externí odkaz:
https://doaj.org/article/3201d717df9a454294ba10866f94190a