Zobrazeno 1 - 10
of 40
pro vyhledávání: '"P. R. Kinchington"'
Autor:
Cristina Tommasi, Ohad Yogev, Michael B. Yee, Andriani Drousioti, Meleri Jones, Alice Ring, Manuraj Singh, Inga Dry, Oscar Atkins, Aishath S. Naeem, Nisha Kriplani, Arne N. Akbar, Jürgen G. Haas, Edel A. O’Toole, Paul R. Kinchington, Judith Breuer
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Varicella-zoster virus (VZV) is the etiological agent of chickenpox and shingles, diseases characterised by epidermal virus replication in skin and mucosa and the formation of blisters. We have previously shown that VZV infection has a profo
Externí odkaz:
https://doaj.org/article/09112decde4b4fc2923182d25e256520
Autor:
Carina Jacobsen, Nina Plückebaum, George Ssebyatika, Sarah Beyer, Lucas Mendes-Monteiro, Jiayi Wang, Kai A. Kropp, Víctor González-Motos, Lars Steinbrück, Birgit Ritter, Claudio Rodríguez-González, Heike Böning, Eirini Nikolouli, Paul R. Kinchington, Nico Lachmann, Daniel P. Depledge, Thomas Krey, Abel Viejo-Borbolla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract During primary varicella zoster virus (VZV) infection, infected lymphocytes drive primary viremia, causing systemic dissemination throughout the host, including the skin. This results in cytokine expression, including interferons (IFNs), whi
Externí odkaz:
https://doaj.org/article/0569487febc14ccf86b8f547b6011d69
Autor:
James McNulty, Chanti Babu-Dokuburra, Jon Scattolon, Carlos Zepeda-Velazquez, Maribeth A. Wesesky, Jill K. Caldwell, Wenxiao Zheng, Jadranka Milosevic, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar, Leonardo D’Aiuto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A dihydronarciclasine derivatives enabled identification of the 7-hydroxyl derivative as a potent and selective antiviral agent targeting SARSCoV-2 and HSV-1. The c
Externí odkaz:
https://doaj.org/article/27af499616bc42268d26cedeb59add2c
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
Varicella zoster virus (VZV) induces orofacial pain and female rats show greater pain than male rats. During the proestrus phase of the estrous cycle the VZV induce pain response is attenuated in female rats. A screen of gene expression changes in di
Externí odkaz:
https://doaj.org/article/41ae63a624cd4ddb9e5e160e03683021
Autor:
Leonardo D’Aiuto, Jill K. Caldwell, Callen T. Wallace, Tristan R. Grams, Maribeth A. Wesesky, Joel A. Wood, Simon C. Watkins, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar
Publikováno v:
Cells, Vol 11, Iss 22, p 3539 (2022)
Intrauterine infections during pregnancy by herpes simplex virus (HSV) can cause significant neurodevelopmental deficits in the unborn/newborn, but clinical studies of pathogenesis are challenging, and while animal models can model some aspects of di
Externí odkaz:
https://doaj.org/article/3e1e0d48f52b43589d053a8362073025
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen. HSV-1 genomes persist in trigeminal ganglia neuronal nuclei as chromatinized episomes, while epithelial cells are typically killed by lytic infection. Fluctuations in anti-viral respo
Externí odkaz:
https://doaj.org/article/0e199e00dce443458b977777b454dded
Autor:
Benjamin E Warner, Michael B Yee, Mingdi Zhang, Rebecca S Hornung, Benedikt B Kaufer, Robert J Visalli, Phillip R Kramer, William F Goins, Paul R Kinchington
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009689 (2021)
Herpes zoster, the result of varicella-zoster virus (VZV) reactivation, is frequently complicated by difficult-to-treat chronic pain states termed postherpetic neuralgia (PHN). While there are no animal models of VZV-induced pain following viral reac
Externí odkaz:
https://doaj.org/article/7914fd3dbf8b4fda9a084c32ac862fb1
Autor:
Punam Bisht, Biswajit Das, Tatiana Borodianskiy-Shteinberg, Paul R. Kinchington, Ronald S. Goldstein
Publikováno v:
Viruses, Vol 14, Iss 5, p 1015 (2022)
Locked-nucleotide analog antagonists (LNAA) to four varicella zoster virus small non-coding RNA (VZVsncRNA 10–13) derived from the mRNA of the open reading frame (ORF) 61 gene individually reduce VZV replication in epithelial cells and fibroblasts.
Externí odkaz:
https://doaj.org/article/a3837512b64f4d74a5f7249c15a7f320
Autor:
Siqi Xiong, Ajay Kumar, Shenghe Tian, Eman E Taher, Enzhi Yang, Paul R Kinchington, Xiaobo Xia, Yiqin Du
Publikováno v:
eLife, Vol 10 (2021)
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular
Externí odkaz:
https://doaj.org/article/f4dede9d3541464b8a84336a192fba28
Autor:
Brian P. McSharry, Carolyn Samer, Hamish E.G. McWilliam, Caroline L. Ashley, Michael B. Yee, Megan Steain, Ligong Liu, David P. Fairlie, Paul R. Kinchington, James McCluskey, Allison Abendroth, Jose A. Villadangos, Jamie Rossjohn, Barry Slobedman
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2948-2962.e4 (2020)
Summary: The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 biosynthesis pathway, viruses have not prev
Externí odkaz:
https://doaj.org/article/8166c32232ce4ae29169a6ca737613b4