Zobrazeno 1 - 10
of 23
pro vyhledávání: '"P. R. Judge"'
Autor:
Andrea N. Riner, Kelly M. Herremans, Vignesh Vudatha, Song Han, Xufeng Qu, Jinze Liu, Nitai Mukhopadhyay, Devon C. Freudenberger, Thomas J. George, Sarah M. Judge, Andrew R. Judge, Steven J. Hughes, Jose G. Trevino
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 149-158 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is highly associated with cachexia and weight loss, which is driven by the tumour's effect on the body. Data are lacking on differences in these metrics based on PDAC anatomic location. We h
Externí odkaz:
https://doaj.org/article/8b79d152af8740b48f6cb1720b637f74
Autor:
Daria Neyroud, Orlando Laitano, Aneesha Dasgupta, Christopher Lopez, Rebecca E. Schmitt, Jessica Z. Schneider, David W. Hammers, H. Lee Sweeney, Glenn A. Walter, Jason Doles, Sarah M. Judge, Andrew R. Judge
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigate the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting ind
Externí odkaz:
https://doaj.org/article/325bfe808b054fee84c0ec177166dbea
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Scott M. Ebert, Celine S. Nicolas, Paul Schreiber, Jaime G. Lopez, Alan T. Taylor, Andrew R. Judge, Sarah M. Judge, Blake B. Rasmussen, John J. Talley, Christophe A. Rème, Christopher M. Adams
Publikováno v:
Animals, Vol 14, Iss 2, p 186 (2024)
Muscle atrophy and weakness are prevalent and debilitating conditions in dogs that cannot be reliably prevented or treated by current approaches. In non-canine species, the natural dietary compound ursolic acid inhibits molecular mechanisms of muscle
Externí odkaz:
https://doaj.org/article/493b01afca24468aa78b04e49c41e4a3
Autor:
Miles E. Cameron, Patrick W. Underwood, Iverson E. Williams, Thomas J. George, Sarah M. Judge, Joshua F. Yarrow, Jose G. Trevino, Andrew R. Judge
Publikováno v:
Cancer Medicine, Vol 11, Iss 1, Pp 50-60 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of all common malignancies. Treatment is difficult and often complicated by the presence of cachexia. The clinical portrait of cachexia contributes to the poor prognosis experien
Externí odkaz:
https://doaj.org/article/7670238a22ff4d2688bc8b0af8d4a791
Autor:
Daria Neyroud, Rachel L. Nosacka, Chandler S. Callaway, Jose G. Trevino, Hui Hu, Sarah M. Judge, Andrew R. Judge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 2, Pp 421-442 (2021)
Abstract Background Skeletal muscle wasting is a devastating consequence of cancer that affects up to 80% of cancer patients and associates with reduced survival. Herein, we investigated the biological significance of Forkhead box P1 (FoxP1), a trans
Externí odkaz:
https://doaj.org/article/4e73b23dea1342c8b4dc6a678fe8f944
Autor:
Rachel L. Nosacka, Andrea E. Delitto, Dan Delitto, Rohan Patel, Sarah M. Judge, Jose G. Trevino, Andrew R. Judge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 820-837 (2020)
Abstract Background Cancer cachexia is a life‐threatening metabolic syndrome that causes significant loss of skeletal muscle mass and significantly increases mortality in cancer patients. Currently, there is an urgent need for better understanding
Externí odkaz:
https://doaj.org/article/fec1822908404b5ea5613e6838d4592f
Autor:
Jennifer B. Permuth, Ashley Clark Daly, Daniel Jeong, Jung W. Choi, Miles E. Cameron, Dung‐Tsa Chen, Jamie K. Teer, Tracey E. Barnett, Jiannong Li, Benjamin D. Powers, Nagalakshmi B. Kumar, Thomas J. George, Karla N. Ali, Tri Huynh, Shraddha Vyas, Clement K. Gwede, Vani N. Simmons, Pamela J. Hodul, Estrella M. Carballido, Andrew R. Judge, Jason B. Fleming, Nipun Merchant, Jose G. Trevino
Publikováno v:
Cancer Medicine, Vol 8, Iss 6, Pp 3314-3324 (2019)
Abstract Pancreatic cancer (PC) is characterized by racial/ethnic disparities and the debilitating muscle‐wasting condition, cancer cachexia. Florida ranks second in the number of PC deaths and has a large and understudied minority population. We e
Externí odkaz:
https://doaj.org/article/4f5fe1ef9f3f497e9b3028594501715a
Autor:
Daryl P. Fields, Brandon M. Roberts, Alec K. Simon, Andrew R. Judge, David D. Fuller, Gordon S. Mitchell
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 63-72 (2019)
Abstract Background Cancer cachexia is an insidious process characterized by muscle atrophy with associated motor deficits, including diaphragm weakness and respiratory insufficiency. Although neuropathology contributes to muscle wasting and motor de
Externí odkaz:
https://doaj.org/article/61b06452b4394bf4b153caf8d82baea9
Autor:
Michael R. Deyhle, Chandler S. Callaway, Daria Neyroud, Andrew C. D’Lugos, Sarah M. Judge, Andrew R. Judge
Publikováno v:
Cells, Vol 11, Iss 12, p 1893 (2022)
Immune cells can mount desirable anti-cancer immunity. However, some immune cells can support cancer disease progression. The presence of cancer can lead to production of immature myeloid cells from the bone marrow known as myeloid-derived suppressor
Externí odkaz:
https://doaj.org/article/fee68e17f9f44e74aeccd5d04c839a17