Zobrazeno 1 - 10
of 65
pro vyhledávání: '"P. R. Flatt"'
Publikováno v:
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 17 (2024)
Obesity and diabetes mellitus are prevalent metabolic disorders that have a detrimental impact on overall health. In this regard, there is now a clear link between these metabolic disorders and compromised bone health. Interestingly, both obesity and
Externí odkaz:
https://doaj.org/article/1101955a3b23497eb912bf8cd44725b0
Autor:
Ananyaa Sridhar, Dawood Khan, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Nigel Irwin, Charlotte R Moffett
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286062 (2023)
Roux-en-Y gastric-bypass (RYGB) induced alterations in intestinal morphology and gut-cell hormone expression profile in the bypassed biliopancreatic-limb (BPL) versus the alimentary-limbs (AL) are poorly characterised. This pilot study has therefore
Externí odkaz:
https://doaj.org/article/792751f6c6904d4587ea405c97f389e9
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
In folklore, Heritiera fomes (H. fomes) has been extensively used in treatment of various ailments such as diabetes, cardiac and hepatic disorders. The present study aimed to elucidate the antidiabetic actions of hot water extract of H. fomes (HWHF),
Externí odkaz:
https://doaj.org/article/22ae5a85ea8244be951077b5991f979c
Autor:
Ananyaa Sridhar, Dawood Khan, Mahmoud Abdelaal, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Carel W Le Roux, Neil G Docherty, Charlotte R Moffett
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274788 (2022)
Modification of gut-islet secretions after Roux-En-Y gastric bypass (RYBG) surgery contributes to its metabolic and anti-diabetic benefits. However, there is limited knowledge on tissue-specific hormone distribution post-RYGB surgery and how this com
Externí odkaz:
https://doaj.org/article/3a023b714adc451694f8d1bcc25bef79
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/d3219a927e2c4b1ba590b7fb88c8644b
Autor:
Dawood Khan, Opeolu O. Ojo, Orla RM Woodward, Jo Edward Lewis, Ananyaa Sridhar, Fiona M. Gribble, Frank Reimann, Peter R. Flatt, R. Charlotte Moffett
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1736 (2022)
Substantial evidence suggests crosstalk between reproductive and gut-axis but mechanisms linking metabolism and reproduction are still unclear. The present study evaluated the possible role of glucose-dependent-insulinotropic-polypeptide (GIP) and gl
Externí odkaz:
https://doaj.org/article/961674cc46fe46c19f2d2d8f7320ae5b
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Combined activation of GLP-1 and CCK1 receptors has potential to synergistically augment the appetite-suppressive and glucose homeostatic actions of the individual parent peptides. In the current study, pancreatic beta-cell benefits of combined GLP-1
Externí odkaz:
https://doaj.org/article/b02a839e593e45f6b44ad783e6dc51a0
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Initially discovered as an impurity in insulin preparations, our understanding of the hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With description of the precursor proglucagon, we now appreciate that glucagon was jus
Externí odkaz:
https://doaj.org/article/d0a5795b66e245ce963d4e2a4e609ce0
Autor:
Ryan A. Lafferty, Neil Tanday, R. Charlotte Moffett, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Nigel Irwin
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diab
Externí odkaz:
https://doaj.org/article/ff3f9ed79ae042faab83503d27504daa
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261608 (2021)
Ac3IV (Ac-CYIQNCPRG-NH2) is an enzymatically stable vasopressin analogue that selectively activates Avpr1a (V1a) and Avpr1b (V1b) receptors. In the current study we have employed streptozotocin (STZ) diabetic transgenic Ins1Cre/+;Rosa26-eYFP and GluC
Externí odkaz:
https://doaj.org/article/75b3bdc019de4bc9b4e239e37829fc65