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Autor: K. H. Antonin, P. R. Bieck

Publikováno v: Early Phase Drug Evaluation in Man ISBN: 9781349107070

Most drugs are administered orally, and the gastrointestinal tract is frequently exposed to high concentrations of substances given with the aim of acting at low concentrations elsewhere in the body. It is known that a number of drugs influence physi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0567f2820ace39194a1dfea24b91d590
https://doi.org/10.1201/9780367812454-44

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Monoamine Oxidase Inhibition in Healthy Volunteers by CGP 11305 A, a New Specific Inhibitor of MAO-A

Autor: K. H. Antonin, P. R. Bieck, Maria Jedrychowski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25e0788e6782513876d9e22afe820512
https://doi.org/10.1159/000407503

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Pharmakokinetik und relative Bioverfügbarkeit von Opipramol aus einem INSIDON®-Dragée

Autor: E. Schmidt, K. H. Antonin, S. M. Rimmele, P. R. Bieck, Nilsson E. B

Publikováno v: Fortschritte der Neurologie · Psychiatrie. 66:S13-S16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c0d80b77ad89b569dc8cd5bb4fe49e1
https://doi.org/10.1055/s-2007-1001158

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Influence of age, frailty and liver function on the pharmacokinetics of brofaromine

Autor: Bergmann W, L. Fuchs, P. R. Bieck, Zeeh J, K. H. Antonin, Degel F, Dieter Platt

Publikováno v: European Journal of Clinical Pharmacology. 49:387-391

The pharmacokinetics of brofaromine, a selective inhibitor of monoamine oxidase A, was evaluated in 12 frail elderly patients (66-92 y) and 12 healthy volunteers (20-35 y).Quantitative liver function tests were performed to show whether brofaromine e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da70db872a6712037d9779c7e47d4d95
https://doi.org/10.1007/bf00203783

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Clinical pharmacology of the new COMT inhibitor CGP 28 014

Autor: Margherita Strolin Benedetti, Erik B. Nilsson, Peter C. Waldmeier, P. R. Bieck, Eckhart K. Schmidt, Gisbert Farger, K. H. Antonin, Philippe Dostert

Publikováno v: Neurochemical Research. 18:1163-1167

CGP 28,014 is a specific inhibitor of catechol-O-methyltransferase (COMT) in vivo. In humans, the inhibition was assessed by measuring urinary excretion of isoquinolines and with the levodopa test. Following administration of CGP 28,014, urinary excr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f331c4a59325d8db805122a893028fb7
https://doi.org/10.1007/bf00978368

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Metabolism of the new MAO-A inhibitor brofaromine in poor and extensive metabolizers of debrisoquine

Autor: N. Feifel, P. R. Bieck, M. Jedrychowski, E. K. Schmidt

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 11:251-255

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cec2b8a3e844e0314edf612ca1c8fc2
https://doi.org/10.1016/0731-7085(93)80205-f

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Administration of Sympathomimetic Drugs with the Selective MAO-A Inhibitor Brofaromine

Autor: P. R. Bieck, B. Mühlbauer, K. H. Antonin, G. Gradin-Frimmer, C. H. Gleiter

Publikováno v: Drug Investigation. 4:149-154

The interaction between the sympathomimetic agents phenylephrine and phenylpropanol-amine (as used in cold remedies or anorexiants) and the new selective and reversible MAO-A inhibitor brofaromine (Consonar®) 75mg administered twice daily for 10 day

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05283658ad9ca6c144a9f9a48f0ab7f5
https://doi.org/10.1007/bf03258393

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Intravenous amine pressor tests in healthy volunteers

Autor: K. H. Antonin, P. R. Bieck, I. W. Reimann, L. Firkusny

Publikováno v: European Journal of Clinical Pharmacology. 42:137-141

The pressor effect of intravenous tyramine (TYR) and noradrenaline (NA) has been evaluated, respectively, in 157 tests in 19 healthy unmedicated subjects, and in 202 tests in 24 similar subjects, all of whom took part in greater than or equal to 3 te

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https://doi.org/10.1007/bf00278472

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Monoamin-Oxidase-Hemmer

Autor: M. Gerlach, P. Riederer, J. R. Martin, R. Amrein, P. C. Waldmeier, R. Kettler, E. Borroni, A. Cesura, E. Grünblatt, K. Jorga, J. G. Richards, M. Da Prada, G. Laux, T. Becker, U. Müller, P. R. Bieck, M. P. Schmauss, T. W. Guentert

Publikováno v: Neuro-Psychopharmaka Ein Therapie-Handbuch ISBN: 9783211836477

Die Monoamin-Oxidase (MAO, EC 1.4.2.4; Amin: Sauerstoff-Oxidoreduktase [desaminierend]) ist ein relativ unspezifisches mitochondriales Enzym. Es metabolisiert monoaminerge Neurotransmitter (wie Adrenalin, Noradrenalin, Dopamin) und Neuromodulatoren (

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https://doi.org/10.1007/978-3-7091-6150-0_7

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Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not ?2-adrenoceptor binding to intact platelets in man

Autor: I. W. Reimann, K. H. Antonin, L. Firkusny, P. R. Bieck

Publikováno v: European Journal of Clinical Pharmacology. 44:93-95

The optically active isomers of the racemic tetracyclic antidepressant oxaprotiline, R (-) oxaprotiline CGP 12,103 A (levoprotiline) and the S (+) oxaprotiline CGP 12,104 A, have been used as tools for a methodological Phase I study. Only the S (+) e

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https://doi.org/10.1007/bf00315288

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