Zobrazeno 1 - 10
of 74
pro vyhledávání: '"P. Povarnina"'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 14-22 (2024)
Relevance. The nerve growth factor (NGF), possessing neuroprotective and neuroregenerative properties, holds promise for the development of medications for the treatment of post-stroke conditions. At the Federal Research Center for Innovator and Emer
Externí odkaz:
https://doaj.org/article/abc97dadc5dd418eafc6078384111850
Autor:
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 41-47 (2024)
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues. The aim is to study the tissue availa
Externí odkaz:
https://doaj.org/article/5c7f5e8406504c54875dd3d0b9f6d420
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 50-55 (2023)
Background. Cyclo-L-prolylglycine (CPG) was designed and synthesized at the V.V. Zakusov as a topological analogue of the classical nootrop piracetam and was further identified as an endogenous compound. Previously, the nootropic effect of CPG was
Externí odkaz:
https://doaj.org/article/c9034e386a724e5da60cea30e5df46cb
Autor:
O. Yu. Kravtsova, O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 12-18 (2023)
The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intrave
Externí odkaz:
https://doaj.org/article/e8c497f291f7473f9c19ee94ffb123e4
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 45-50 (2023)
Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total
Externí odkaz:
https://doaj.org/article/0d75a82fad4a4f0fbc7c3ac2b3898929
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 50-54 (2023)
The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance. The significant decrease in the binding of BDNF
Externí odkaz:
https://doaj.org/article/00c2a6dcdaad4c679147cb8df67df9d3
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 9-13 (2022)
Background. The dipeptide drug Noopept, created at the Zakusov Institute of Pharmacology, has a wide range of pharmacological actions, including cytoprotective one. In connection with the increasing pollution of the environment, it is urgent to ident
Externí odkaz:
https://doaj.org/article/78aa1bf10e2747c8821569974ec3dbe2
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 36-43 (2022)
Background. A dimeric dipeptide mimetic of the brain-derived neurotrophic factor loop 4, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106), which activates TrkB, PI3K/AKT, MAPK/ERK and PLC-γ1 was created at the V. V. Zakusov Resear
Externí odkaz:
https://doaj.org/article/dcdbb4348f0e41098c77a33022b9c429
Akademický článek
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Autor:
A. G. Mezhlumyan, A. V. Tallerova, P. Yu. Povarnina, N. M. Sazonova, A. V. Tarasiuk, T. A. Gudasheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 11-17 (2020)
At the Zakusov Institute of Pharmacology designed and synthesized dimeric dipeptide mimetics of the 1st (GK-6) and 4th (GK-2) nerve growth factor loops, 1st (GSB-214), 2nd (GTS-201) and 4th (GSB -106, GSB-106Ac) brain-derived neurotrophic factor loop
Externí odkaz:
https://doaj.org/article/d4dfcd3deb5448cbb115f2500a9500cc