Výsledky vyhledávání - "P. Piccardoni"

Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin

Autor: Romina Pecce, Giorgio Berton, Nicola Martelli, Clifford A. Lowell, Chiara Cerletti, Virgilio Evangelista, Lorenzo Federico, P Piccardoni, Licia Totani, Susan S. Smyth, Stefano Manarini, Antonio Piccoli

Publikováno v: Biochemical Journal. 396:89-98

In cell suspensions subjected to high-shear rotatory motion, human PMN (polymorphonuclear cells) adhered to E-selectin-expressing CHO (Chinese-hamster ovary) cells (CHO-E), and formed homotypic aggregates when challenged by E-selectin-IgG fusion prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664739ec00bbd6c2350155a21c96c921
https://doi.org/10.1042/bj20051924

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SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells

Autor: Licia Totani, Antonio Piccoli, Nicola Martelli, Zsuzsa Bagoly, Romina Pecce, Virgilio Evangelista, Stefano Manarini, Lorenzo Federico, Chiara Cerletti, P Piccardoni

Publikováno v: Biochemical Journal. 380:57-65

In human PMN (polymorphonuclear cells), challenged by P-selectin, the beta2-integrin Mac-1 (macrophage antigen-1) promoted the activation of the SRC (cellular homologue of Rous sarcoma virus oncogenic protein) family members HCK (haematopoietic cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d5d1c57a25e794c77fb0b60a193d93
https://doi.org/10.1042/bj20040151

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Platelet/Polymorphonuclear Leukocyte Interaction: P-Selectin Triggers Protein-Tyrosine Phosphorylation–Dependent CD11b/CD18 Adhesion: Role of PSGL-1 as a Signaling Molecule

Autor: Antonio Piccoli, Licia Totani, Rita Sideri, Nicola Martelli, Dietmar Vestweber, Serenella Rotondo, Virgilio Evangelista, Giovanni de Gaetano, Chiara Cerletti, P Piccardoni, S. Manarini

Publikováno v: Blood. 93:876-885

Polymorphonuclear leukocyte (PMN) adhesion to activated platelets is important for the recruitment of PMN at sites of vascular damage and thrombus formation. We have recently shown that binding of activated platelets to PMN in mixed cell suspensions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6a4ba685fc6024ca287787256a649f0
https://doi.org/10.1182/blood.v93.3.876

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Synthesis of Some Guanylhydrazones and Imidazolinylhydrazones as Thromboxane-Synthase and Platelet Aggregation Inhibitors

Autor: Serenella Rotondo, P. Piccardoni, M. L. Stein, Nicoletta Desideri, Chiara Cerletti, I. Sestili

Publikováno v: Archiv der Pharmazie. 325:773-777

The imidazolinylhydrazones of (3-pyridinyloxy)-acetaldehyde and of 6-[3-(2-formyl-pyridinyl)oxy]hexanoic acid were synthesized as cyclic analogues of the corresponding guanylhydrazones which were found to be selective inhibitors of human thromboxane-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6ee6800e0a6aa43030ca3cb73c34e4
https://doi.org/10.1002/ardp.19923251206

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Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinases: role of P-selectin-mediated cell-cell adhesion

Autor: JG White, Virgilio Evangelista, G. de Gaetano, P. Piccardoni, Chiara Cerletti

Publikováno v: Europe PubMed Central

Human PMN stimulated by fMLP are able to activate coincubated, autologous platelets. Cathepsin G, a neutral serine protease stored in the azurophilic granules of PMN, is the major platelet activator in this system. We previously proposed that shear-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b3661d9259712c13a726b667151b51
https://pubmed.ncbi.nlm.nih.gov/7684621

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Polymorphonuclear leukocytes modulate platelet function

Autor: Marina Molino, Virgilio Evangelista, C. Cerletti, N. Maugeri, P. Piccardoni, G. de Gaetano

Publikováno v: The Role of Platelets in Blood-Biomaterial Interactions ISBN: 9789401047654

After Giulio Bizzozero in 1882 first reported the simultaneous involvement of leukocytes and platelets in thrombus formation [1], the presence of polymorphonuclear leukocytes (PMN) in hemostatic platelet plug and arterial thrombi has been repeatedly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8d5eb45cd0a97a355804adaf181aed3
https://doi.org/10.1007/978-94-011-1745-6_8

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Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes

Autor: C. Cerletti, G. de Gaetano, Virgilio Evangelista, P Piccardoni

Publikováno v: Europe PubMed Central

SummaryDefibrotide is a polydeoxyribonucleotide with antithrombotic effects in experimental animal models. Most of the actions of this drug have been observed in in vivo test models but no effects have been reported in in vitro systems. In this paper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8fa8dec8480251ada8ee6fd838e100
https://pubmed.ncbi.nlm.nih.gov/1509406

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