Zobrazeno 1 - 10
of 762
pro vyhledávání: '"P. Peakman"'
Autor:
Anne Eugster, Anna Lorenc, Martin Kotrulev, Yogesh Kamra, Manisha Goel, Katja Steinberg-Bains, Shereen Sabbah, Sevina Dietz, Ezio Bonifacio, Mark Peakman, Iria Gomez-Tourino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autoimmune diseases result from autoantigen-mediated activation of adaptive immunity; intriguingly, autoantigen-specific T cells are also present in healthy donors. An assessment of dynamic changes of this autoreactive repertoire in both hea
Externí odkaz:
https://doaj.org/article/232b3f7f7b544729b1e9d70d032e0c11
Autor:
Charles Taylor, Georgia Peakman, Lauren Mackinnon, Navid Mohamadzade, Wayne Han, Lucy Mackie, Jasmine Gandhi, Oliver Mitchell, Caitlin Bateman-Champain, Joseph Hetherington, Fahed Belarbi, Gaggandeep Alg
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Delirium is a common and reversible neurobehavioral condition with significant morbidity and mortality ramifications for older patients. Consequentially, clear guidelines exist pertaining to its swift identification and management
Externí odkaz:
https://doaj.org/article/3e35ce7d154e4f0bbe6a004828793281
Autor:
Jerod L. Ptacin, Lina Ma, Carolina E. Caffaro, Nicole V. Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M. San Jose, Hans R. Aerni, David B. Chen, Ean Esche, Taylor K. Ismaili, Rob Herman, Yelena Pavlova, Michael J. Pena, Jasmine Nguyen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Jill Mooney, Mark Peakman, Marcos E. Milla
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of aut
Externí odkaz:
https://doaj.org/article/224e433676bd420da232e1c317680a2d
Autor:
Kiran Samra, Georgia Peakman, Amy M. MacDougall, Arabella Bouzigues, Caroline V. Greaves, Rhian S. Convery, John C. vanSwieten, Lize Jiskoot, Harro Seelaar, Fermin Moreno, Raquel Sanchez‐Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre deMendonça, Chris R. Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer, Lucy L. Russell, Genetic FTD Initiative (GENFI)
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION We aimed to expand the range of the frontotemporal dementia (FTD) phenotypes assessed by the Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains (CDR p
Externí odkaz:
https://doaj.org/article/8ed7a9e8c76e4d6ca6c25a487b06eec3
Autor:
Anisha Ramessur, Bana Ambasager, Iker Valle Aramburu, Freddie Peakman, Kelly Gleason, Christoph Lehmann, Venizelos Papayannopoulos, Raoul Charles Coombes, Ilaria Malanchi
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Purpose An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow cancer-dependent priming is found. However, how early this priming is detectable remains unclear. Patients and
Externí odkaz:
https://doaj.org/article/ef57165dca85401589110eed0e990aa2
Autor:
Peakman, Aiden, Gregg, Robert
There is a strong motivation to develop high-power output nuclear fission reactors (around 1 MWe) for space applications, such as high-payload missions and long-duration missions beyond Mars, where the reduced solar flux makes using alternative energ
Externí odkaz:
http://arxiv.org/abs/2004.12116
Akademický článek
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Akademický článek
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Autor:
Latif Rachdi, Zhicheng Zhou, Claire Berthault, Chloe Lourenço, Alexis Fouque, Thomas Domet, Mathieu Armanet, Sylvaine You, Mark Peakman, Roberto Mallone, Raphael Scharfmann
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104740- (2023)
Summary: Background: To resist the autoimmune attack characteristic of type 1 diabetes, insulin producing pancreatic β cells need to evade T-cell recognition. Such escape mechanisms may be conferred by low HLA class I (HLA-I) expression and upregula
Externí odkaz:
https://doaj.org/article/c606494ecc3c41ff9dd6a8dbda428a1a
If international agreements regarding the need to significantly reduce greenhouse gas emissions are to be met then there is a high probability that the shipping industry will have to dramatically reduce its greenhouse gas emissions. For emission redu
Externí odkaz:
http://arxiv.org/abs/1901.10977