Zobrazeno 1 - 10
of 216
pro vyhledávání: '"P. Patriarchi"'
Autor:
Marie A. Labouesse, Maria Wilhelm, Zacharoula Kagiampaki, Andrew G. Yee, Raphaelle Denis, Masaya Harada, Andrea Gresch, Alina-Măriuca Marinescu, Kanako Otomo, Sebastiano Curreli, Laia Serratosa Capdevila, Xuehan Zhou, Reto B. Cola, Luca Ravotto, Chaim Glück, Stanislav Cherepanov, Bruno Weber, Xin Zhou, Jason Katner, Kjell A. Svensson, Tommaso Fellin, Louis-Eric Trudeau, Christopher P. Ford, Yaroslav Sych, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. H
Externí odkaz:
https://doaj.org/article/edad0bcf8205400a8af1560d0567e9ed
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A. Bhat, Ananya S. Achanta, Joseph C. Johnson, Amanda Loren Pasqualini, Sanjana Jadhav, Corinna A. Bauder, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Azra Suko, Richard D. Palmiter, Miriam Stoeber, Peter Kloppenburg, Jens C. Brüning, Michael R. Bruchas, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action
Externí odkaz:
https://doaj.org/article/85f93020cae0443ca2de0481924bf37c
Autor:
Reto B Cola, Salome N Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A Bhat, Kevin Assoumou, Elyse T Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Publikováno v:
eLife, Vol 13 (2024)
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1P78A, a novel genetically e
Externí odkaz:
https://doaj.org/article/83a204a88f8b464d90811cb0b5e39796
Autor:
Yucui Chen, Shangming Liu, Ariel A. Jacobi, Grace Jeng, Jason D. Ulrich, Ivar S. Stein, Tommaso Patriarchi, Johannes W. Hell
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Rapid, synapse-specific neurotransmission requires the precise alignment of presynaptic neurotransmitter release and postsynaptic receptors. How postsynaptic glutamate receptor accumulation is induced during maturation is not well understood. We find
Externí odkaz:
https://doaj.org/article/6d7dffd05015408a8a2becc1cdb91599
Publikováno v:
eLife, Vol 12 (2024)
Dopamine and orexins (hypocretins) play important roles in regulating reward-seeking behaviors. It is known that hypothalamic orexinergic neurons project to dopamine neurons in the ventral tegmental area (VTA), where they can stimulate dopaminergic n
Externí odkaz:
https://doaj.org/article/8283c27b38cb4045981fb9599b10407b
Autor:
Annina Stuber, Anna Cavaccini, Andreea Manole, Anna Burdina, Yassine Massoud, Tommaso Patriarchi, Theofanis Karayannis, Nako Nakatsuka
Publikováno v:
ACS Measurement Science Au, Vol 4, Iss 1, Pp 92-103 (2023)
Externí odkaz:
https://doaj.org/article/9538e27f9a9e436aaab8b8ab08768784
Autor:
Armando G. Salinas, Jeong Oen Lee, Shana M. Augustin, Shiliang Zhang, Tommaso Patriarchi, Lin Tian, Marisela Morales, Yolanda Mateo, David M. Lovinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The development of genetically encoded dopamine sensors such as dLight has provided a new approach to measuring slow and fast dopamine dynamics both in brain slices and in vivo, possibly enabling dopamine measurements in areas like the dorso
Externí odkaz:
https://doaj.org/article/00c2d19f80214233be1c3432d94f4dc6
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