Výsledky vyhledávání - "P. P. Sayeski"

Akademický článek

The effects of student- and teacher-led tootling on student disruptive behavior

Autor: Jillian M. Thoele, Kristin L. Sayeski

Publikováno v: Frontiers in Education, Vol 9 (2024)

The foundation of effective management lies in the recognition and reinforcement of appropriate behaviors. Researchers have found that class-wide, group-contingency-based classroom management approaches can be an efficient and effective way to promot

Externí odkaz: https://doaj.org/article/8bda8a275bf740f19e44ca85c6a4cc64

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Akademický článek

Whole-exome sequencing in evaluation of patients with venous thromboembolism

Publikováno v: Blood Advances, Vol 1, Iss 16, Pp 1224-1237 (2017)

Abstract: Genetics play a significant role in venous thromboembolism (VTE), yet current clinical laboratory-based testing identifies a known heritable thrombophilia (factor V Leiden, prothrombin gene mutation G20210A, or a deficiency of protein C, pr

Externí odkaz: https://doaj.org/article/c274b1de27734d959984c4c6623722ac

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Akademický článek

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Akademický článek

The Jak2 Inhibitor, G6, Alleviates Jak2-V617F–Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow

Autor: Annet Kirabo, Sung O. Park, Anurima Majumder, Meghanath Gali, Mary K. Reinhard, Heather L. Wamsley, Zhizhuang Joe Zhao, Christopher R. Cogle, Kirpal S. Bisht, György M. Keserű, Peter P. Sayeski

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 11, Pp 1058-1068 (2011)

We recently developed a Janus kinase 2 (Jak2) small-molecule inhibitor called G6 and found that it inhibits Jak2-V617F– mediated pathologic cell growth in vitro, ex vivo, and in vivo. However, its ability to inhibit Jak2-V617F–mediated myeloproli

Externí odkaz: https://doaj.org/article/70c68f511e8d44e5ab68dbc16ad18285

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Akademický článek

Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease

Autor: Peter P. Sayeski, Annet Kirabo

Publikováno v: Pharmaceuticals, Vol 3, Iss 11, Pp 3478-3493 (2010)

Patients with hypertension often manifest a dysregulated renin-angiotensin-aldosterone system (RAAS). Most of the available treatment approaches for hypertension are targeted towards the RAAS including direct renin inhibition, ACE inhibition, angiote

Externí odkaz: https://doaj.org/article/55745b60d0ab46a2804e0a70eb39c549

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Akademický článek

The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

Autor: Rebekah Baskin, Sung O Park, György M Keserű, Kirpal S Bisht, Heather L Wamsley, Peter P Sayeski

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105568 (2014)

Glioblastoma multiforme (GBM) is the most common and the most aggressive form of primary brain tumor. Jak2 is a non-receptor tyrosine kinase that is involved in proliferative signaling through its association with various cell surface receptors. Hype

Externí odkaz: https://doaj.org/article/9e84e3bfef61404195949588e53b6766

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Akademický článek

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.

Autor: Sung O Park, Heather L Wamsley, Kyungmi Bae, Zhongbo Hu, Xiaomiao Li, Se-woon Choe, William B Slayton, S Paul Oh, Kay-Uwe Wagner, Peter P Sayeski

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59675 (2013)

Germline deletion of Jak2 in mice results in embryonic lethality at E12.5 due to impaired hematopoiesis. However, the role that Jak2 might play in late gestation and postnatal life is unknown. To understand this, we utilized a conditional knockout ap

Externí odkaz: https://doaj.org/article/107094f9362e4f75bcb3a3f489558848

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