Zobrazeno 1 - 10
of 43
pro vyhledávání: '"P. P. M. De Lange"'
Autor:
Anneke L. Eerkens, Koen Brummel, Annegé Vledder, Sterre T. Paijens, Marta Requesens, Dominik Loiero, Nienke van Rooij, Annechien Plat, Floris-Jan Haan, Patty Klok, Refika Yigit, Thijs Roelofsen, Natascha M. de Lange, Rie Klomp, David Church, Arja ter Elst, René Wardenaar, Diana Spierings, Floris Foijer, Viktor Hendrik Koelzer, Tjalling Bosse, Joost Bart, Mathilde Jalving, Anna K. L. Reyners, Marco de Bruyn, Hans W. Nijman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Neoadjuvant immune checkpoint blockade (ICB) has shown unprecedented activity in mismatch repair deficient (MMRd) colorectal cancers, but its effectiveness in MMRd endometrial cancer (EC) remains unknown. In this investigator-driven, phase I
Externí odkaz:
https://doaj.org/article/1b7aedf643dd44ed914769ada0de8d61
Publikováno v:
Human Biology and Public Health, Vol 2 (2023)
Background: Linear enamel hypoplasia (LEH) and porous cranial lesions such as cribra orbitalia (CO) and porotic hyperostosis (PH) are considered nonspecific indicators of early childhood metabolic stress. Objectives: The study aims to describe the
Externí odkaz:
https://doaj.org/article/dabf6678e4c84de8b01b6096d243794e
Autor:
Huib A M Kerstjens, Tjip S van der Werf, Jan-Willem C Alffenaar, Simon Tiberi, Lies ter Beek, Mathieu S Bolhuis, Harriët Jager-Wittenaar, René X D Brijan, Marieke G G Sturkenboom, Wiel C M de Lange, Onno W Akkerman
Publikováno v:
BMJ Open, Vol 11, Iss 12 (2021)
Objectives Malnutrition is associated with a twofold higher risk of dying in patients with tuberculosis (TB) and considered an important potentially reversible risk factor for failure of TB treatment. The construct of malnutrition has three domains:
Externí odkaz:
https://doaj.org/article/fcbe91b36bac445380342ef37c8f5aa1
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-33 (2019)
Abstract The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain may be substantially different from that in the blood. Within the brain, the drug
Externí odkaz:
https://doaj.org/article/481ca802d2bd41459f11ea5d733d8a5f
Autor:
M. Pape, G. F. Giannakópoulos, W. P. Zuidema, E. S. M. de Lange-Klerk, E. J. Toor, M. J. R. Edwards, M. H. J. Verhofstad, T. N. Tromp, E. M. M. van Lieshout, F. W. Bloemers, L. M. G. Geeraedts
Publikováno v:
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 27, Iss 1, Pp 1-10 (2019)
Abstract Introduction Little evidence suggest that female gender is associated with a lower risk of mortality in severely injured patients, especially in premenopausal women. Previous clinical studies have shown contradictory results regarding protec
Externí odkaz:
https://doaj.org/article/fd9bb85270624cf5b9dca5bea3eaa770
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1764 (2022)
The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally believed unidirectional and constant CSF circulation, has been demonstrated. In the present study, the structure and parameters of the CSF compartments we
Externí odkaz:
https://doaj.org/article/6322cb82e42441bb9ce9a278b8f1cf65
Autor:
Pim B B Schol, Natascha M de Lange, Mallory D Woiski, Josje Langenveld, Luc J M Smits, Martine M Wassen, Yvonne M Henskens, Hubertina C J Scheepers
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253765 (2021)
BackgroundEvidence for optimal hemostatic resuscitation in postpartum hemorrhage (PPH) is lacking. Liberal fluid administration may result in acidosis, hypothermia and coagulopathy.ObjectiveWe hypothesize that in early PPH a restrictive fluid adminis
Externí odkaz:
https://doaj.org/article/cbd3b2dc45be4f6a8fce2ac5ebbc6ebf
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
BackgroundDespite the known health benefits of physical activity, the number of older adults exercising regularly remains low in many countries. There is a demand for public open space interventions that can safely train balance, muscular strength, a
Externí odkaz:
https://doaj.org/article/70b612da33d94920a2a2a5de82b1d1ea
Publikováno v:
Reading & Writing, Vol 11, Iss 1, Pp e1-e9 (2020)
Background: The Progress in International Reading Literacy Study (PIRLS), and similar international assessments, have consistently shown South African intermediate phase learners’ performance to be among the lowest worldwide. Of particular concern
Externí odkaz:
https://doaj.org/article/050214a817394ed0b7955c75f4adb4aa
Autor:
Iris M. de Lange, Flip Mulder, Ruben van 'tSlot, Anja C. M. Sonsma, Marjan J. A. vanKempen, Isaac J. Nijman, Robert F. Ernst, Nine V. A. M. Knoers, Eva H. Brilstra, Bobby P. C. Koeleman
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Background SCN1A is one of the most important epilepsy‐related genes, with pathogenic variants leading to a range of phenotypes with varying disease severity. Different modifying factors have been hypothesized to influence SCN1A‐related
Externí odkaz:
https://doaj.org/article/97de1f8e82f840b394c981f1155af6e1