Zobrazeno 1 - 10
of 65
pro vyhledávání: '"P. O. Bochkov"'
Autor:
Sh. P. Abdullaev, M. N. Shatokhin, O. L. Sigailo, P. O. Bochkov, S. N. Tuchkova, O. V. Teodorovich, O. B. Loran, D. A. Sychev
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 12, Iss 1, Pp 32-48 (2024)
Tamsulosin is a first-line drug in the treatment of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Despite high estimates of its efficacy and safety, it rates may vary due to genetic polymorphisms of genes for the enzymes
Externí odkaz:
https://doaj.org/article/f02b442bb3354354abbb0375f040f972
Autor:
l. V. Fedina, i. N. Sychev, K. V. Mirzaev, A. V. Vardanyan, S. V. Glagolev, A. A. Kachanova, P. O. Bochkov, R. V. Shevchenko, S. N. Tuchkova, I. V. Sychev, S. P. Abdullaev, D A. Sychev
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 20, Iss 1, Pp 19-26 (2024)
Aim. The aim of our study was to investigate the influence of polymorphic markers of CYP3A4*22 CYP3A4*22 (c.522-191C>T, rs35599367), CYP3A5*3 (c.219237A>G, rs776746), ABCB1 rs1045642 (c.3435T>C) and rs4148738 (c.2692-2236C>T) genes on the plasma conc
Externí odkaz:
https://doaj.org/article/895693a579cb4ad08184d9190f32a514
Autor:
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 41-47 (2024)
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues. The aim is to study the tissue availa
Externí odkaz:
https://doaj.org/article/5c7f5e8406504c54875dd3d0b9f6d420
Autor:
O. Yu. Kravtsova, O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 12-18 (2023)
The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intrave
Externí odkaz:
https://doaj.org/article/e8c497f291f7473f9c19ee94ffb123e4
Autor:
N. A. Shatalova, D. A. Sychev, K. B. Mirzaev, A. I. Kochetkov, E. Yu. Ebzeeva, V. B. Dashabylova, P. O. Bochkov, S. N. Tuchkova, S. V. Glagolev
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 19, Iss 5, Pp 470-478 (2023)
Aim. To study the possible relationship between polymorphic variants of ABCB1 (rs2032582, rs1045642, rs1128503), CYP3A5 (rs776746), CYP3A4 (rs35599367) and CYP2J2 (rs890293) genes with residual equilibrium concentrations (Cmin,ss) of rivaroxaban in p
Externí odkaz:
https://doaj.org/article/9a8bd307ca844343b2cc8835a800342f
Autor:
L. V. Fedina, I. N. Sychev, T. D. Rastvorova, E. V. Strigunkova, A. A. Kachanova, Z. A. Sozaeva, P. O. Bochkov, A. V. Vardanyan, K. B. Mirzayev, D. A. Sychev
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 18, Iss 6, Pp 624-629 (2023)
Aim. To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis.Material and methods. Patients hospitalized at Yudin Sta
Externí odkaz:
https://doaj.org/article/547d7b56152449b99e64946f0dcd6d76
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 37-45 (2022)
GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative determination of GIZh-298 in rat blood plasma has been developed and validated. The linear
Externí odkaz:
https://doaj.org/article/562d748deb1d4666a79264303ed54545
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 17-22 (2022)
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose
Externí odkaz:
https://doaj.org/article/5ca71ab2babf4e178b06dbb833a39cc2
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 31-35 (2022)
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates t
Externí odkaz:
https://doaj.org/article/3a4c660664214e5daed6a73af1144d8f
Autor:
P. O. Bochkov, I. P. Khrustova, A. A. Litvin, G. B. Kolyvanov, R. V. Shevchenko, V. P. Zherdev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 3-10 (2022)
GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures of racetams that combine anticonvulsant and nootropic effects. The method of high-performance liquid chromatography with mass spectrometric detection was developed and valid
Externí odkaz:
https://doaj.org/article/63a5555a5add49528ba5775e7a283f70