Zobrazeno 1 - 10
of 39
pro vyhledávání: '"P. N. Span"'
Autor:
F. V. Reinema, F. C. G. J. Sweep, G. J. Adema, W. J. M. Peeters, J. W. M. Martens, J. Bussink, P. N. Span
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we investigated the mechanisms associated with tamoxifen-induced radioresistance, aiming to prevent or reverse re
Externí odkaz:
https://doaj.org/article/65e65290676f4fa18d55dcd8e0866ed2
Autor:
Bas P. H. Adriaansen, Mariska A. M. Schröder, Paul N. Span, Fred C. G. J. Sweep, Antonius E. van Herwaarden, Hedi L. Claahsen-van der Grinten
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Congenital adrenal hyperplasia (CAH) due to 21α-hydroxylase deficiency (21OHD) or 11β-hydroxylase deficiency (11OHD) are congenital conditions with affected adrenal steroidogenesis. Patients with classic 21OHD and 11OHD have a (nearly) complete enz
Externí odkaz:
https://doaj.org/article/98e97c9d76e5434592ee3066ad8017d6
Autor:
Marleen Ansems, Paul N. Span
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 22, Iss , Pp 90-97 (2020)
Tumor growth is not only dictated by events involving tumor cells, but also by the environment they reside in, the so-called tumor microenvironment (TME). In the TME, cancer-associated fibroblasts (CAFs) are often the predominant cell type. CAFs were
Externí odkaz:
https://doaj.org/article/f6a19ec9c0d44f86b7d0f0665aa6bc6f
Autor:
Tineke W.H. Meijer, Monika G. Looijen‐Salamon, Jasper Lok, Michel van denHeuvel, Bastiaan Tops, Johannes H.A.M. Kaanders, Paul N. Span, Johan Bussink
Publikováno v:
Thoracic Cancer, Vol 10, Iss 12, Pp 2289-2299 (2019)
Abstract Background Both hypoxia and oncogenic mutations rewire tumor metabolism. In this study, glucose and glutamine metabolism‐related markers were examined in stage I ‐ resectable stage IIIA non‐small cell lung cancer (NSCLC). Furthermore,
Externí odkaz:
https://doaj.org/article/e133b3e905be4966be6a33cad0fbac94
Autor:
Altuna Halilovic, Dagmar I. Verweij, Annet Simons, Marian J. P. L. Stevens-Kroef, Susan Vermeulen, Janet Elsink, Bastiaan B. J. Tops, Irene Otte-Höller, Jeroen A. W. M. van der Laak, Carlijn van de Water, Oliver B. A. Boelens, Margrethe S. Schlooz-Vries, Jeroen R. Dijkstra, Iris D. Nagtegaal, Jolien Tol, Patricia H. J. van Cleef, Paul N. Span, Peter Bult
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Breast cancer treatment depends on human epidermal growth factor receptor-2 (HER2) status, which is often determined using dual probe fluorescence in situ hybridisation (FISH). Hereby, also loss and gain of the centromere of chromosome 17 (C
Externí odkaz:
https://doaj.org/article/eccb0d74ba084146a4c3d5d34a19dea5
Autor:
Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap, William P. J. Leenders
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-k
Externí odkaz:
https://doaj.org/article/134a2d6836154e8195617e7ff0cbfff9
Autor:
Myrthe J. M. Verhees, Manon Engels, Paul N. Span, Fred C. G. J. Sweep, Antonius E. van Herwaarden, Henrik Falhammar, Anna Nordenström, Emma A. Webb, Annette Richter-Unruh, Claire Bouvattier, Aude Brac de la Perrière, Wiebke Arlt, Nicole Reisch, Birgit Köhler, Marion Rapp, Nike M. M. L. Stikkelbroeck, Nel Roeleveld, Hedi L. Claahsen-van der Grinten
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a disorder of adrenal steroid biosynthesis, leading to hypocortisolism, hypoaldosteronism, and hyperandrogenism. Impaired quality of life (QoL) has been demonstrated in
Externí odkaz:
https://doaj.org/article/139af0e0c1a84096aae75811337fa356
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
In response to the recent paper by Chen et al investigating the triple combination of oxidative phosphorylation inhibition, immunotherapy and radiotherapy, we would like to stress that after irradiation, a strong reduction in hypoxia (within 24 hours
Externí odkaz:
https://doaj.org/article/03387f4b9c1c4cb296676e283d484c9e
Autor:
Ying Zhang, Chunling Tang, Paul N. Span, Alan E. Rowan, Tilly W. Aalders, Jack A. Schalken, Gosse J. Adema, Paul H. J. Kouwer, Mirjam M. P. Zegers, Marleen Ansems
Publikováno v:
Advanced Science, Vol 7, Iss 18, Pp n/a-n/a (2020)
Abstract In the last decade, organoid technology has developed as a primary research tool in basic biological and clinical research. The reliance on poorly defined animal‐derived extracellular matrix, however, severely limits its application in reg
Externí odkaz:
https://doaj.org/article/32d252598691473f9cbef5880a8fb8e0
Autor:
Pieter A Roelofs, Chai Yeen Goh, Boon Haow Chua, Matthew C Jarvis, Teneale A Stewart, Jennifer L McCann, Rebecca M McDougle, Michael A Carpenter, John WM Martens, Paul N Span, Dennis Kappei, Reuben S Harris
Publikováno v:
eLife, Vol 9 (2020)
APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element medi
Externí odkaz:
https://doaj.org/article/562661be3bbb4115a4d955575847fc12