Zobrazeno 1 - 4
of 4
pro vyhledávání: '"P. N. Spalton"'
Publikováno v:
Xenobiotica. 10:705-713
1. On administration of a single oral dose of [4-(14)C]ethynodiol diacetate (0.15 mg/kg) to rhesus monkey, plasma concn. of total 14C peaked after about 4 h. About 60% of the plasma radioactivity was present as glucuronide conjugates and no unchanged
Autor:
R. F. Palmer, K. A. Waddell, G. C. Ford, T. J. Forrest, N. J. Haskins, P. N. Spalton, Christine M. Walls
Publikováno v:
Biological Mass Spectrometry. 7:80-83
The stable isotope co-administration technique for estimating the bioavailability of drugs has been investigated in a series of experiments using rhesus monkeys. The compound chosen for study was disopyramide phosphate. A cross-over study was designe
Autor:
D. A. Rose, A. Barrow, P. N. Spalton, R. D. Brownsill, Y. Gunn, C. M. Walls, N. J. Haskins, R. F. Palmer
Publikováno v:
Xenobiotica. 10:219-228
1. The disposition of [14C]pranolium chloride, a dimethyl quaternary derivative of propranolol, has been studied in rats, mice and hamsters after oral or parenteral dosage.2. Elimination of 14C occurred largely via the kidneys after parenteral dosage
Autor:
P N, Spalton, J M, Clifford
Publikováno v:
Laboratory animal science. 29(2)
A duodenal tube was introduced into the duodenum of the fasted baboon via the nasal passage. After the application of vacuum for several minutes, the baboon received an intravenous injection of pancreozymin and cholecystokinin which caused contractio