Výsledky vyhledávání - "P. N. Confalone"

Human moricizine metabolism. I. Isolation and identification of metabolites in human urine

Autor: H. J. Pieniaszek, J. M. Read, P. N. Confalone, G. O. Page, A. F. Davidson, L. E. Richards, S. Shatzmiller, K. F. Blom

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(2)

1. Using synthetic standards and/or spectral data, seven moricizine metabolites were structurally identified in human urine. Two novel metabolites were identified as phenothiazine-2-carbamic acid and ethyl [10-(3-aminopropionyl) phenothiazin-2-yl] ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd73c54b17a148dd0b42b7f1d15a2152
https://pubmed.ncbi.nlm.nih.gov/9058534

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Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas

Publikováno v: Journal of medicinal chemistry. 39(18)

High-resolution X-ray structures of the complexes of HIV-1 protease (HIV-1PR) with peptidomimetic inhibitors reveal the presence of a structural water molecule which is hydrogen bonded to both the mobile flaps of the enzyme and the two carbonyls flan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca252d7787d2a50a77209a603a4cff0c
https://pubmed.ncbi.nlm.nih.gov/8784449

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Synthesis of BMS-561392

Autor: M. Yates, P. N. Confalone, R. E. Waltermire, D. J. Meloni, S. A. Savage, R. G. Wethman, N. A. Magnus, S. Campagna

Publikováno v: Synfacts. 2010:0513-0513

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d9aea73ef14dc94189d5b51bb6c964d
https://doi.org/10.1055/s-0029-1219645

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Peptide synthesis with benzisoxazolium salts—I

Autor: S. W. Wang, P. N. Confalone, S.-I. Hsia, R. C. Mollan, Daniel S. Kemp

Publikováno v: Tetrahedron. 30:3677-3688

The general features and limitations of 2-ethylbenzisoxazolium fluoroborate as a peptide coupling reagent are described. Strategies for effecting improvements through benzo substitution led to the preparation and study of the 5-nitro, 7-hydroxy, 5-ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7e860d3f2d07d92d19f620dab45007d
https://doi.org/10.1016/s0040-4020(01)90651-9

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The metabolism of 14C-methoxsalen by the dog

Autor: S J, Kolis, T H, Williams, E J, Postma, G J, Sasso, P N, Confalone, M A, Schwartz

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 7(4)

Single doses of 14C-methoxsalen (5 mg/kg) were administered iv to three dogs. Almost as much administered radioactivity was excreted in the feces as in the urine, suggesting that biliary secretion of metabolites was an important route of excretion. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a508812e5f39db30c00a9baf08b5552c
https://pubmed.ncbi.nlm.nih.gov/39724

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