Zobrazeno 1 - 10
of 37
pro vyhledávání: '"P. Mathijs Voorhoeve"'
Autor:
Hung Thanh Nguyen, Xin Hong, Sam Tan, Qingfeng Chen, Lifang Chan, Marc Fivaz, Stephen M. Cohen, P. Mathijs Voorhoeve
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 707-713 (2014)
Primary human cells can be transformed into tumor cells by a defined set of genetic alterations including telomerase, oncogenic RasV12, and the tumor suppressors p53 and pRb. SV40 small T (ST) is required for anchorage-independent growth in vitro and
Externí odkaz:
https://doaj.org/article/ee18232ab2bf4df9a3bb3e6eb9fad805
Autor:
Victor Ho, Shi Yun Yeo, Kamini Kunasegaran, Duvini De Silva, Gerard A. Tarulli, P. Mathijs Voorhoeve, Alexandra M. Pietersen
Publikováno v:
BioTechniques, Vol 54, Iss 4, Pp 208-212 (2013)
Since tissues and tumors are heterogenous populations containing different cell types, their transcriptomes are blends of multiple mRNA expression profiles. Although fluorescence-activated cell sorting (FACS) allows isolation of individual cell types
Externí odkaz:
https://doaj.org/article/6ef278a150b744909383c21aceb294fd
Autor:
Patrick Tan, P. Mathijs Voorhoeve, Nallasivam Palanisamy, Sun-Young Rha, Kalpana Ramnarayanan, Julian Lee, Emmanuel Beillard, Iain BeeHuat Tan, Nian-Tao Deng, Chia-Huey Ooi, Kakoli Das, Angie Lay-Keng Tan, Hue-Kian Oh
Purpose: MicroRNAs (miRNA) play pivotal oncogenic and tumor-suppressor roles in several human cancers. We sought to discover novel tumor-suppressor miRNAs in gastric cancer (GC).Experimental Design: Using Agilent miRNA microarrays, we compared miRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b868ccbaaee447140b26b1012bbcec81
https://doi.org/10.1158/1078-0432.c.6519584.v1
https://doi.org/10.1158/1078-0432.c.6519584.v1
Autor:
Patrick Tan, P. Mathijs Voorhoeve, Nallasivam Palanisamy, Sun-Young Rha, Kalpana Ramnarayanan, Julian Lee, Emmanuel Beillard, Iain BeeHuat Tan, Nian-Tao Deng, Chia-Huey Ooi, Kakoli Das, Angie Lay-Keng Tan, Hue-Kian Oh
Supplementary Figures S1-S4; Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bb0b94bf1f8bb0dce4baa8d8c0b5a9
https://doi.org/10.1158/1078-0432.22442966.v1
https://doi.org/10.1158/1078-0432.22442966.v1
Autor:
Edward S Y Wong, Sandhya Shekar, Claire H T Chan, Lewis Z Hong, Suk-Yean Poon, Toomas Silla, Clarabelle Lin, Vikrant Kumar, Sonia Davila, Mathijs Voorhoeve, Aye Aye Thike, Gay Hui Ho, Yoon Sim Yap, Puay Hoon Tan, Min-Han Tan, Peter Ang, Ann S G Lee
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134408 (2015)
The National Comprehensive Cancer Network (NCCN) has proposed guidelines for the genetic testing of the BRCA1 and BRCA2 genes, based on studies in western populations. This current study assessed potential predictive factors for BRCA mutation probabi
Externí odkaz:
https://doaj.org/article/17fe3ee275054f9785a5cbd94d4b7ec0
Autor:
Toomas Silla, Katrin Kepp, E Shyong Tai, Liang Goh, Sonia Davila, Tina Catela Ivkovic, George A Calin, P Mathijs Voorhoeve
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110692 (2014)
Ultra-conserved genes or elements (UCGs/UCEs) in the human genome are extreme examples of conservation. We characterized natural variations in 2884 UCEs and UCGs in two distinct populations; Singaporean Chinese (n = 280) and Italian (n = 501) by usin
Externí odkaz:
https://doaj.org/article/3fa302a4e0474c78a284e4e44fa94713
Autor:
P. Mathijs Voorhoeve, Qingfeng Chen, Rui Zhang, Hung Thanh Nguyen, Xin Hong, Stephen M. Cohen, Zandra Hagman
Publikováno v:
The EMBO Journal
Cancer genomes accumulate numerous genetic and epigenetic modifications. Yet, human cellular transformation can be accomplished by a few genetically defined elements. These elements activate key pathways required to support replicative immortality an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee729b4805e228f7de9ee6eb0c10e5ee
http://europepmc.org/articles/PMC4283404
http://europepmc.org/articles/PMC4283404
Autor:
Marc Fivaz, Qingfeng Chen, Xin Hong, Lifang Chan, Sam Tan, Stephen M. Cohen, Hung Thanh Nguyen, P. Mathijs Voorhoeve
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 707-713 (2014)
SummaryPrimary human cells can be transformed into tumor cells by a defined set of genetic alterations including telomerase, oncogenic RasV12, and the tumor suppressors p53 and pRb. SV40 small T (ST) is required for anchorage-independent growth in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd0927055c7c6eb1c15260ac00ad0cf
https://doi.org/10.1016/j.celrep.2014.06.062
https://doi.org/10.1016/j.celrep.2014.06.062
Autor:
Cui Rong Teo, Patrick J. Casey, Emmanuel Beillard, Suhail Ahmed Kabeer Rasheed, P. Mathijs Voorhoeve
Publikováno v:
Journal of Biological Chemistry. 288:7986-7995
G protein-coupled receptors (GPCRs) and their ligands have been implicated in progression and metastasis of several cancers. GPCRs signal through heterotrimeric G proteins, and among the different types of G proteins, GNA12/13 have been most closely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ad61c217559119d2db6690c20f340
https://doi.org/10.1074/jbc.m112.437749
https://doi.org/10.1074/jbc.m112.437749
Publikováno v:
Genes & Development. 26:1602-1611
MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of oncogenes in tumor formation and disease progression. This poses the challenge of identifying the miRNA targets responsible for these interactions. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c183695455aeafe863e0e6888987613
https://doi.org/10.1101/gad.192021.112
https://doi.org/10.1101/gad.192021.112