Zobrazeno 1 - 10
of 66
pro vyhledávání: '"P. M. van Koetsveld"'
Autor:
Maria J. Klomp, Julie Refardt, Peter M. van Koetsveld, Claudia Campana, Simone U. Dalm, Fadime Dogan, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. de Herder, Johannes Hofland, Leo J. Hofland
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundSomatostatin receptor type 2 (SST2) expression is critical for the diagnosis and treatment of neuroendocrine tumors and is associated with improved patient survival. Recent data suggest that epigenetic changes such as DNA methylation and hi
Externí odkaz:
https://doaj.org/article/7942dd91c0ec4a4293b961afd26f2d10
Autor:
Rebecca V. Steenaard, Richard A. Feelders, Fadime Dogan, Peter M. van Koetsveld, Sara G. Creemers, Madeleine H. T. Ettaieb, Folkert J. van Kemenade, Harm R. Haak, Leo J. Hofland
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 2013 (2023)
The differentiation between benign and malignant adrenocortical tumors based on pathological assessment can be difficult. We present a series of 17 patients with unclear malignant tumors, of whom six had recurrent or metastatic disease. The assessmen
Externí odkaz:
https://doaj.org/article/8dd6353959154a04a0b15c6b72a9d90b
Autor:
Amber Blaauboer, Stephanie Booy, Peter M. van Koetsveld, Bas Karels, Fadime Dogan, Suzanne van Zwienen, Casper H. J. van Eijck, Leo J. Hofland
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Adjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with treatment resistance. We aimed to evaluate the chemosensitising effect of interferon-beta (IFN-β
Externí odkaz:
https://doaj.org/article/d7528e192b7149b28bd793a959ebfbe7
Autor:
Şeyda Berk, Joseph A. M. J. L. Janssen, Peter M. van Koetsveld, Fadime Dogan, Naci Değerli, Servet Özcan, Fahrettin Kelestimur, Leo J. Hofland
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
There are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In the present study, we studied in vitro in human co
Externí odkaz:
https://doaj.org/article/43c77b5f198b45df994fe31a982172e4
Autor:
Thomas Cuny, Peter M. van Koetsveld, Grégoire Mondielli, Fadime Dogan, Wouter W. de Herder, Anne Barlier, Leo J. Hofland
Publikováno v:
Cancers, Vol 14, Iss 14, p 3481 (2022)
Introduction: Pancreatic neuroendocrine neoplasms (PNENs) present with a fibrotic stroma that constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts in the growth of PNENs and their sensitivity to the mTOR inhibitor RAD0
Externí odkaz:
https://doaj.org/article/42cab8ca77144828bf23c186309ce496
Autor:
Amber Blaauboer, Peter M. van Koetsveld, Dana A. M. Mustafa, Jasper Dumas, Fadime Dogan, Suzanne van Zwienen, Casper H. J. van Eijck, Leo J. Hofland
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 517 (2022)
Background: Gemcitabine efficacy in pancreatic cancer is often impaired due to limited intracellular uptake and metabolic activation. Epi-drugs target gene expression patterns and represent a promising approach to reverse chemoresistance. In this stu
Externí odkaz:
https://doaj.org/article/96249b3ee7e54ccc9aba41e9ef64d9cb
Autor:
Maria J. Klomp, Leo J. Hofland, Lilian van den Brink, Peter M. van Koetsveld, Fadime Dogan, Corrina M. A. de Ridder, Debra C. Stuurman, Marian C. Clahsen-van Groningen, Marion de Jong, Simone U. Dalm
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 173 (2022)
Background: To improve peptide receptor radionuclide therapy (PRRT), we aimed to enhance the expression of somatostatin type-2 receptors (SSTR2) in vitro and in vivo, using valproic acid (VPA). Methods: Human NCI-H69 small-cell lung carcinoma cells w
Externí odkaz:
https://doaj.org/article/3243ddd2fe374fbdbeed5ab236f4efc7
Autor:
Maria J. Klomp, Simone U. Dalm, Peter M. van Koetsveld, Fadime Dogan, Marion de Jong, Leo J. Hofland
Publikováno v:
Cancers, Vol 13, Iss 19, p 4905 (2021)
The aim of this study was to increase somatostatin type-2 receptor (SSTR2) expression on neuroendocrine tumor (NET) cells using histone deacetylase inhibitors (HDACis), potentially increasing the uptake of SSTR2-targeted radiopharmaceuticals and subs
Externí odkaz:
https://doaj.org/article/269e5ef6f1df4186a9dafa553e4092e4
Autor:
Slávka Kaščáková, Leo J Hofland, Henriette S De Bruijn, Yunpeng Ye, Samuel Achilefu, Katy van der Wansem, Angelique van der Ploeg-van den Heuvel, Peter M van Koetsveld, Michael P Brugts, Aart-Jan van der Lelij, Henricus J C M Sterenborg, Timo L M Ten Hagen, Dominic J Robinson, Martin P van Hagen
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104448 (2014)
Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain anatomical sites, improved targeting
Externí odkaz:
https://doaj.org/article/9b9219fc88574fb5bd0233b77d0ce699
Autor:
Gaston J H Franssen, W. W. de Herder, P. M. van Koetsveld, Richard A Feelders, Leo J. Hofland, Sara G Creemers, E. S. R. van den Dungen, Esther Korpershoek, F.J. van Kemenade
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, 101(12), 4574-4584. Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 101(12), 4574-4584. Endocrine Society
Context: Treatment of patients with adrenocortical carcinomas (ACC) with mitotane and/or chemotherapy is often associated with toxicity and poor tumor response. New therapeutic options are urgently needed. Objective: The objectives of the study were