Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer

Autor: Jessica Bigge, Laura L. Koebbe, Ann-Sophie Giel, Dorothea Bornholdt, Benedikt Buerfent, Pouria Dasmeh, Alexander M. Zink, Carlo Maj, Johannes Schumacher

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract Background Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL

Externí odkaz: https://doaj.org/article/39bb89b9844e4b128a1bed8a54997d50

Specimen collection is essential for modern science.

Autor: Michael W Nachman, Elizabeth J Beckman, Rauri Ck Bowie, Carla Cicero, Chris J Conroy, Robert Dudley, Tyrone B Hayes, Michelle S Koo, Eileen A Lacey, Christopher H Martin, Jimmy A McGuire, James L Patton, Carol L Spencer, Rebecca D Tarvin, Marvalee H Wake, Ian J Wang, Anang Achmadi, Sergio Ticul Álvarez-Castañeda, Michael J Andersen, Jairo Arroyave, Christopher C Austin, F Keith Barker, Lisa N Barrow, George F Barrowclough, John Bates, Aaron M Bauer, Kayce C Bell, Rayna C Bell, Allison W Bronson, Rafe M Brown, Frank T Burbrink, Kevin J Burns, Carlos Daniel Cadena, David C Cannatella, Todd A Castoe, Prosanta Chakrabarty, Jocelyn P Colella, Joseph A Cook, Joel L Cracraft, Drew R Davis, Alison R Davis Rabosky, Guillermo D'Elía, John P Dumbacher, Jonathan L Dunnum, Scott V Edwards, Jacob A Esselstyn, Julián Faivovich, Jon Fjeldså, Oscar A Flores-Villela, Kassandra Ford, Jérôme Fuchs, Matthew K Fujita, Jeffrey M Good, Eli Greenbaum, Harry W Greene, Shannon Hackett, Amir Hamidy, James Hanken, Tri Haryoko, Melissa Tr Hawkins, Lawrence R Heaney, David M Hillis, Bradford D Hollingsworth, Angela D Hornsby, Peter A Hosner, Mohammad Irham, Sharon Jansa, Rosa Alicia Jiménez, Leo Joseph, Jeremy J Kirchman, Travis J LaDuc, Adam D Leaché, Enrique P Lessa, Hernán López-Fernández, Nicholas A Mason, John E McCormack, Caleb D McMahan, Robert G Moyle, Ricardo A Ojeda, Link E Olson, Chan Kin Onn, Lynne R Parenti, Gabriela Parra-Olea, Bruce D Patterson, Gregory B Pauly, Silvia E Pavan, A Townsend Peterson, Steven Poe, Daniel L Rabosky, Christopher J Raxworthy, Sushma Reddy, Alejandro Rico-Guevara, Awal Riyanto, Luiz A Rocha, Santiago R Ron, Sean M Rovito, Kevin C Rowe, Jodi Rowley, Sara Ruane, David Salazar-Valenzuela, Allison J Shultz, Brian Sidlauskas, Derek S Sikes, Nancy B Simmons, Melanie L J Stiassny, Jeffrey W Streicher, Bryan L Stuart, Adam P Summers, Jose Tavera, Pablo Teta, Cody W Thompson, Robert M Timm, Omar Torres-Carvajal, Gary Voelker, Robert S Voss, Kevin Winker, Christopher Witt, Elizabeth A Wommack, Robert M Zink

Publikováno v: PLoS Biology, Vol 21, Iss 11, p e3002318 (2023)

Natural history museums are vital repositories of specimens, samples and data that inform about the natural world; this Formal Comment revisits a Perspective that advocated for the adoption of compassionate collection practices, querying whether it w

Externí odkaz: https://doaj.org/article/29b3f135891b4b13b5f2dfbb06a42081

Specialization in a Nitrogen-Fixing Symbiosis: Proteome Differences Between Sinorhizobium medicae Bacteria and Bacteroids

Autor: Svetlana N. Yurgel, Yi Qu, Jennifer T. Rice, Nivethika Ajeethan, Erika M. Zink, Joseph M. Brown, Sam Purvine, Mary S. Lipton, Michael L. Kahn

Publikováno v: Molecular Plant-Microbe Interactions, Vol 34, Iss 12, Pp 1409-1422 (2021)

Using tandem mass spectrometry (MS/MS), we analyzed the proteome of Sinorhizobium medicae WSM419 growing as free-living cells and in symbiosis with Medicago truncatula. In all, 3,215 proteins were identified, over half of the open reading frames pred

Externí odkaz: https://doaj.org/article/077b8dd8186e45fcb07d570dcbf0bbe4

The taxonomic basis of subspecies listed as threatened and endangered under the endangered species act

Autor: Robert M. Zink, Luke B. Klicka

Publikováno v: Frontiers in Conservation Science, Vol 3 (2022)

More than 170 subspecies are listed as threatened or endangered under the US Endangered Species Act. Most of these subspecies were described decades ago on the basis of geographical variation in morphology using relatively primitive taxonomic methods

Externí odkaz: https://doaj.org/article/5dee0048da7344fba33e64037585e65d

Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

Autor: Xiaojun Wang, Yanping Xu, Xiaohong Yu, Asim Dey, Hong Y. Zhang, Charity M. Zink, Derek Wodka, Gina Porter, William F. Matter, Leah Porras, Charles A. Reidy, Jeffrey A. Peterson, Brian E. Mattioni, Joseph V. Haas, Mark C. Kowala, John R. Wetterau

Publikováno v: Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)

Abstract An excess phosphate burden in renal disease has pathological consequences for bone, kidney, and heart. Therapies to decrease intestinal phosphate absorption have been used to address the problem, but with limited success. Here, we describe t

Externí odkaz: https://doaj.org/article/b759409794b4455683e748deb0fd6706