Zobrazeno 1 - 10
of 153
pro vyhledávání: '"P. M. Sondel"'
Autor:
Alexander L. Rakhmilevich, Noah W. Tsarovsky, Mildred Felder, Jen Zaborek, Sritha Moram, Amy K. Erbe, Alexander A. Pieper, Dan V. Spiegelman, Emily M. Cheng, Cole M. Witt, Willem W. Overwijk, Zachary S. Morris, Paul M. Sondel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe majority of experimental approaches for cancer immunotherapy are tested against relatively small tumors in tumor-bearing mice, because in most cases advanced cancers are resistant to the treatments. In this study, we asked if even late-
Externí odkaz:
https://doaj.org/article/29d00bafc93a4a5eba1dd4bd66f05425
Autor:
Lauren Zebertavage, Allison Schopf, Megan Nielsen, Joel Matthews, Amy K. Erbe, Taylor J. Aiken, Sydney Katz, Claire Sun, Cole M. Witt, Alexander L. Rakhmilevich, Paul M. Sondel
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 9, p 2561 (2024)
Background: Incorporating GD2-targeting monoclonal antibody into post-consolidation maintenance therapy has improved survival for children with high-risk neuroblastoma. However, ~50% of patients do not respond to, or relapse following, initial treatm
Externí odkaz:
https://doaj.org/article/733faad25dac4283bca0cc877a4c2049
Autor:
Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113556- (2023)
Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinic
Externí odkaz:
https://doaj.org/article/3b49ec059cc6419f9fcdd7b1869fd235
Autor:
Anna Hoefges, Paul M Sondel, Zachary Morris, Nicholas Mathers, Jigar Patel, Irene Ong, Arika S Feils, Sean J Mcilwain, Kaitlin Tetreault, Alina A Hampton, Noah W Tsarovsky, Brad H Garcia, Amy K Erbe-Gurel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/7ae4c5e57b644e1e8466af2f75f76fbe
Autor:
Anna Hoefges, Paul M Sondel, Alexander L Rakhmilevich, Arika S Feils, Alina A Hampton, Noah W Tsarovsky, Amy K Erbe-Gurel, Alexa R Heaton, Nathaniel J Burkard, Garrett M Lublin, Melissa C Skala
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4974d29cc9e9470d91ac46ce206f9c5d
Autor:
Noah Tsarovsky, Mildred Felder, Mackenzie Heck, Jacob Slowinski, Kayla Rasmussen, Sabrina VandenHeuvel, Jen Zaborek, Zachary S. Morris, Amy K. Erbe, Paul M. Sondel, Alexander L. Rakhmilevich
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionWe have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell
Externí odkaz:
https://doaj.org/article/31fc084eb860409982966059be52b354
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment fo
Externí odkaz:
https://doaj.org/article/5182a8b990d848bdaa69308ac2077051
Autor:
Quaovi H. Sodji, Matthew H. Forsberg, Dan Cappabianca, Caroline P. Kerr, Lauren Sarko, Amanda Shea, David P. Adam, Jens C. Eickhoff, Irene M. Ong, Reinier Hernandez, Jamey Weichert, Bryan P. Bednarz, Krishanu Saha, Paul M. Sondel, Christian M. Capitini, Zachary S. Morris
Publikováno v:
Cancers, Vol 16, Iss 1, p 191 (2023)
Background and purpose. Chimeric antigen receptor (CAR) T cells have been relatively ineffective against solid tumors. Low-dose radiation which can be delivered to multiple sites of metastases by targeted radionuclide therapy (TRT) can elicit immunos
Externí odkaz:
https://doaj.org/article/7d0c605fbcef45eca60bbfa20726cba4
Autor:
Zhaoting Li, Yingyue Ding, Jun Liu, Jianxin Wang, Fanyi Mo, Yixin Wang, Ting-Jing Chen-Mayfield, Paul M. Sondel, Seungpyo Hong, Quanyin Hu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Increased density of tumor associated macrophages has been correlated with tumor recurrence following surgery. Here the authors design an alginate-based hydrogel encapsulating anti-PD-1-conjugated platelets and nanoparticles loaded with the macrophag
Externí odkaz:
https://doaj.org/article/130cfa3671404b2bad586cd3dd015a5c
Autor:
Alexa R. Heaton, Peter R. Rehani, Anna Hoefges, Angelica F. Lopez, Amy K. Erbe, Paul M. Sondel, Melissa C. Skala
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMetabolic reprogramming of cancer and immune cells occurs during tumorigenesis and has a significant impact on cancer progression. Unfortunately, current techniques to measure tumor and immune cell metabolism require sample destruction an
Externí odkaz:
https://doaj.org/article/c2c82cf09a1d44eca7d13b82746ddc1c