Zobrazeno 1 - 10
of 471
pro vyhledávání: '"P. M. Sondel"'
Autor:
Alexander L. Rakhmilevich, Noah W. Tsarovsky, Mildred Felder, Jen Zaborek, Sritha Moram, Amy K. Erbe, Alexander A. Pieper, Dan V. Spiegelman, Emily M. Cheng, Cole M. Witt, Willem W. Overwijk, Zachary S. Morris, Paul M. Sondel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe majority of experimental approaches for cancer immunotherapy are tested against relatively small tumors in tumor-bearing mice, because in most cases advanced cancers are resistant to the treatments. In this study, we asked if even late-
Externí odkaz:
https://doaj.org/article/29d00bafc93a4a5eba1dd4bd66f05425
Autor:
Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113556- (2023)
Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinic
Externí odkaz:
https://doaj.org/article/3b49ec059cc6419f9fcdd7b1869fd235
Autor:
Anna Hoefges, Paul M Sondel, Zachary Morris, Nicholas Mathers, Jigar Patel, Irene Ong, Arika S Feils, Sean J Mcilwain, Kaitlin Tetreault, Alina A Hampton, Noah W Tsarovsky, Brad H Garcia, Amy K Erbe-Gurel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/7ae4c5e57b644e1e8466af2f75f76fbe
Autor:
Anna Hoefges, Paul M Sondel, Alexander L Rakhmilevich, Arika S Feils, Alina A Hampton, Noah W Tsarovsky, Amy K Erbe-Gurel, Alexa R Heaton, Nathaniel J Burkard, Garrett M Lublin, Melissa C Skala
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4974d29cc9e9470d91ac46ce206f9c5d
Autor:
Noah Tsarovsky, Mildred Felder, Mackenzie Heck, Jacob Slowinski, Kayla Rasmussen, Sabrina VandenHeuvel, Jen Zaborek, Zachary S. Morris, Amy K. Erbe, Paul M. Sondel, Alexander L. Rakhmilevich
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionWe have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell
Externí odkaz:
https://doaj.org/article/31fc084eb860409982966059be52b354
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment fo
Externí odkaz:
https://doaj.org/article/5182a8b990d848bdaa69308ac2077051
Autor:
Alexa R. Heaton, Peter R. Rehani, Anna Hoefges, Angelica F. Lopez, Amy K. Erbe, Paul M. Sondel, Melissa C. Skala
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMetabolic reprogramming of cancer and immune cells occurs during tumorigenesis and has a significant impact on cancer progression. Unfortunately, current techniques to measure tumor and immune cell metabolism require sample destruction an
Externí odkaz:
https://doaj.org/article/c2c82cf09a1d44eca7d13b82746ddc1c
Autor:
Zhaoting Li, Yingyue Ding, Jun Liu, Jianxin Wang, Fanyi Mo, Yixin Wang, Ting-Jing Chen-Mayfield, Paul M. Sondel, Seungpyo Hong, Quanyin Hu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Increased density of tumor associated macrophages has been correlated with tumor recurrence following surgery. Here the authors design an alginate-based hydrogel encapsulating anti-PD-1-conjugated platelets and nanoparticles loaded with the macrophag
Externí odkaz:
https://doaj.org/article/130cfa3671404b2bad586cd3dd015a5c
Autor:
Rajen Mody, KyungMann Kim, Paul M Sondel, Amy K Erbe, Julie Park, Sabah Servaes, Jen Birstler, Wendy B London, Jung-Tung Hung, Alice L Yu, John M Maris, Mitch B Diccianni, Arlene Naranjo, Fan F Zhang, Arika S Feils, Barry L Shulkin, Varsha Mathew, Marguerite T Parisi, Shahab Asgharzadeh, Rochelle Bagatell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background In the Children’s Oncology Group ANBL1221 phase 2 trial for patients with first relapse/first declaration of refractory high-risk neuroblastoma, irinotecan and temozolomide (I/T) combined with either temsirolimus (TEMS) or immunotherapy
Externí odkaz:
https://doaj.org/article/443a5adb348f4ea680fa7f58633c74ff
Autor:
Zachary S Morris, Paul M Sondel, Amy K Erbe, Alexander L Rakhmilevich, Amber M Bates, Peter M Carlson, Alexander A Pieper, Ravi B Patel, Jen Birstler, Joseph Grudzinski, Reinier Hernandez, Bryan P Bednarz, Jamey P Weichert, Arika S Feils, Matthew Rodriquez, Claire Sun, Ian Marsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background The antitumor effects of external beam radiation therapy (EBRT) are mediated, in part, by an immune response. We have reported that a single fraction of 12 Gy EBRT combined with intratumoral anti-GD2 hu14.18-IL2 immunocytokine (IC) generat
Externí odkaz:
https://doaj.org/article/1ef1a1af9237404b8526eb674951b943