Zobrazeno 1 - 10
of 53
pro vyhledávání: '"P. M. Pitha"'
Autor:
Paula M. Pitha
Publikováno v:
Viruses, Vol 3, Iss 7, Pp 1179-1203 (2011)
As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early inflam
Externí odkaz:
https://doaj.org/article/e5b63b7c68b74cb990e82954c3d14099
Autor:
Hua Cao, Peihong Dai, Weiyi Wang, Hao Li, Jianda Yuan, Fangjin Wang, Chee-Mun Fang, Paula M Pitha, Jia Liu, Richard C Condit, Grant McFadden, Taha Merghoub, Alan N Houghton, James W Young, Stewart Shuman, Liang Deng
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36823 (2012)
Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus. Vaccinia, an
Externí odkaz:
https://doaj.org/article/cf96d89437034ac38ff459b6881fcd8e
Autor:
Hem D. Shukla, Paula M. Pitha
Publikováno v:
Autoimmune Diseases, Vol 2012 (2012)
Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis
Externí odkaz:
https://doaj.org/article/f28a9a4da4404b2e8bca047889c010ba
Publikováno v:
PLoS Pathogens, Vol 7, Iss 1, p e1001246 (2011)
The transcription factor Interferon Regulatory Factor 5 (IRF-5) has been shown to be involved in the induction of proinflammatory cytokines in response to viral infections and TLR activation and to play an essential role in the innate inflammatory re
Externí odkaz:
https://doaj.org/article/a194b680e29944ef80fff987b934f884
Publikováno v:
Proceedings of the National Academy of Sciences. 93:11103-11108
Defective-interfering viruses are known to modulate virus pathogenicity. We describe conditionally replicating HIV-1 (crHIV) vectors that interfere with wild-type HIV-1 (wt-HIV) replication and spread. crHIV vectors are defective-interfering HIV geno
Publikováno v:
The Journal of Immunology. 150:4672-4686
T cell responses play a critical role in host defense against viral infection. Therefore, the functional properties of HIV-1-specific human T cells induced by an experimental AIDS vaccine were analyzed in detail at the clonal level. Seronegative huma
Publikováno v:
The Journal of Immunology. 148:1934-1940
The levels of circulating IFN in mice infected with Newcastle disease virus (NDV) are regulated by the If-1 locus. In this study we show that in NDV-infected C57BL/6 mice, which carry the If-1h allele and produce high levels of IFN, high levels of bo
Publikováno v:
Journal of Interferon Research. 11:9-15
Murine interferon-α4 (MuIFN-α4) is notable among the MuIFN-α subtypes because it lacks 5 amino acids corresponding to postitions 103–107 of the other subtypes, yet is the most highly expressed subtype.(1,2) Site-directed in vitro mutagenesis has
Autor:
P M, Pitha, M S, Kunzi
Publikováno v:
Current topics in microbiology and immunology. 316
Since the discovery of interferon 50 years ago, the understanding of the mechanism of the virus-mediated induction of type I IFN and its function has been under intensive investigation. Remarkable progress has been made in recent years both in the id
Autor:
P. M. Pitha, M. S. Kunzi
Publikováno v:
Interferon: The 50th Anniversary ISBN: 9783540713289
Since the discovery of interferon 50 years ago, the understanding of the mechanism of the virus-mediated induction of type I IFN and its function has been under intensive investigation. Remarkable progress has been made in recent years both in the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61a2660de9e8bc6aade097b7fc4632f
https://doi.org/10.1007/978-3-540-71329-6_4
https://doi.org/10.1007/978-3-540-71329-6_4