Zobrazeno 1 - 10
of 221
pro vyhledávání: '"P. M. Kloetzel"'
Autor:
Peter M. Kloetzel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive T cel
Externí odkaz:
https://doaj.org/article/58c92de146d24299b157c8c1228733f7
Autor:
Gerald Willimsky, Christin Beier, Lena Immisch, George Papafotiou, Vivian Scheuplein, Andrean Goede, Hermann-Georg Holzhütter, Thomas Blankenstein, Peter M Kloetzel
Publikováno v:
eLife, Vol 10 (2021)
Proteasome-catalyzed peptide splicing (PCPS) of cancer-driving antigens could generate attractive neoepitopes to be targeted by T cell receptor (TCR)-based adoptive T cell therapy. Based on a spliced peptide prediction algorithm, TCRs were generated
Externí odkaz:
https://doaj.org/article/9f5ae7c804744ee4a8d414cf5560bcb4
Autor:
Anouk C.M. Platteel, Juliane Liepe, Kathrin Textoris-Taube, Christin Keller, Petra Henklein, Hanna H. Schalkwijk, Rebeca Cardoso, Peter M. Kloetzel, Michele Mishto, Alice J.A.M. Sijts
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1242-1253 (2017)
Summary: Proteasome-catalyzed peptide splicing (PCPS) generates peptides that are presented by MHC class I molecules, but because their identification is challenging, the immunological relevance of spliced peptides remains unclear. Here, we developed
Externí odkaz:
https://doaj.org/article/dbbb84c5c1774707b8e9c342d573f020
Autor:
Lisa K. Wagner, Kate E. Gilling, Eileen Schormann, Peter M. Kloetzel, Frank L. Heppner, Elke Krüger, Stefan Prokop
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases. In
Externí odkaz:
https://doaj.org/article/a9b73025154f41b181059ea1fae940aa
Autor:
Izabela Mlynarczuk-Bialy, Thorsten R. Doeppner, Jakub Golab, Dominika Nowis, Grzegorz M. Wilczynski, Kamil Parobczak, Moritz E. Wigand, Malgorzata Hajdamowicz, Łukasz P. Biały, Olga Aniolek, Petra Henklein, Mathias Bähr, Boris Schmidt, Ulrike Kuckelkorn, Peter-M. Kloetzel
Publikováno v:
Translational Oncology, Vol 7, Iss 5, Pp 570-579 (2014)
Inhibition of the proteasome offers many therapeutic possibilities in inflammation as well as in neoplastic diseases. However, clinical use of proteasome inhibitors is limited by the development of resistance or severe side effects. In our study we c
Externí odkaz:
https://doaj.org/article/dac0949447534c1b883208e645e9afcb
Autor:
Juliane Liepe, Herman-Georg Holzhütter, Peter M. Kloetzel, Michael P. H. Stumpf, Michele Mishto
Publikováno v:
Biomolecules, Vol 4, Iss 2, Pp 585-599 (2014)
Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these protein
Externí odkaz:
https://doaj.org/article/3b995493abdf4de18c6ee277be88eb18
Autor:
Juliane Liepe, Hermann-Georg Holzhütter, Elena Bellavista, Peter M Kloetzel, Michael PH Stumpf, Michele Mishto
Publikováno v:
eLife, Vol 4 (2015)
Proteasomal protein degradation is a key determinant of protein half-life and hence of cellular processes ranging from basic metabolism to a host of immunological processes. Despite its importance the mechanisms regulating proteasome activity are onl
Externí odkaz:
https://doaj.org/article/34a4329b98af46c7a61b15d70d77c7a3
Autor:
Elisa Opitz, Annett Koch, Karin Klingel, Frank Schmidt, Stefan Prokop, Anna Rahnefeld, Martina Sauter, Frank L Heppner, Uwe Völker, Reinhard Kandolf, Ulrike Kuckelkorn, Karl Stangl, Elke Krüger, Peter M Kloetzel, Antje Voigt
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002233 (2011)
Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the
Externí odkaz:
https://doaj.org/article/d2dbeb93a01945528f41de1fbc1d9375
Autor:
Sylvain Cardinaud, Gesa Consiglieri, Romain Bouziat, Alejandra Urrutia, Stéphanie Graff-Dubois, Slim Fourati, Isabelle Malet, Julien Guergnon, Amélie Guihot, Christine Katlama, Brigitte Autran, Peter van Endert, François A Lemonnier, Victor Appay, Olivier Schwartz, Peter M Kloetzel, Arnaud Moris
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002049 (2011)
Cytotoxic CD8+ T cells (CTLs) play a critical role in controlling viral infections. HIV-infected individuals develop CTL responses against epitopes derived from viral proteins, but also against cryptic epitopes encoded by viral alternative reading fr
Externí odkaz:
https://doaj.org/article/11741e79371a421faecf68c1ab9f787a
Autor:
Michele Mishto, Elena Bellavista, Claudia Ligorio, Kathrin Textoris-Taube, Aurelia Santoro, Mara Giordano, Sandra D'Alfonso, Florinda Listì, Benedetta Nacmias, Elena Cellini, Maurizio Leone, Luigi M E Grimaldi, Chiara Fenoglio, Federica Esposito, Filippo Martinelli-Boneschi, Daniela Galimberti, Elio Scarpini, Ulrike Seifert, Maria Pia Amato, Calogero Caruso, Maria P Foschini, Peter M Kloetzel, Claudio Franceschi
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9287 (2010)
BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the prod
Externí odkaz:
https://doaj.org/article/4cb4cbf2336142ff9d2394e21649e691