Zobrazeno 1 - 9 of 9 pro vyhledávání: '"P. M. J. Mcsheehy"'
1
Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo
Autor: P. M. J. Mcsheehy, John R. Griffiths, M. J. W. Prior
Publikováno v: British Journal of Cancer
5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f702c039fa73cd3e827d2539a9527dc7
https://doi.org/10.1038/bjc.1992.75
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2
Osteoblastic Cells Mediate Osteoclastic Responsiveness to Parathyroid Hormone*
Autor: T.J. Chambers, P. M. J. McSHEEHY
Publikováno v: Endocrinology. 118:824-828
Indirect evidence suggests that cells of the osteoblastic lineage may mediate augmented osteoclastic bone resorption induced by PTH. To test this suggestion, osteoclasts were disaggregated from neonatal rat long bones and incubated on slices of human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0dc271296c8661e337d4a15730eef7
https://doi.org/10.1210/endo-118-2-824
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3
Osteoblast-Like Cells in the Presence of Parathyroid Hormone Release Soluble Factor that Stimulates Osteoclastic Bone Resorption*
Autor: P. M. J. McSHEEHY, T.J. Chambers
Publikováno v: Endocrinology. 119:1654-1659
PTH stimulates osteoclastic bone resorption in vivo and in organ culture. We have previously found that if osteoclasts are disaggregated from bone and incubated on bone slices, PTH does not increase bone resorption, but does so if osteoblastic cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3350ca826f22948b8672321db970ade2
https://doi.org/10.1210/endo-119-4-1654
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4
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo
Autor: John R. Griffiths, P. M. J. Mcsheehy, M. J. W. Prior
Publikováno v: British Journal of Cancer
19F-magnetic resonance spectroscopy (MRS) can be used to non-invasively monitor metabolism of 5-fluorouracil (5FU) to cytotoxic fluoronucleotides (FNuct). We investigated whether the levels of FNuct formed from 5FU and observed in vivo by MRS in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe3969eeffbe9036fc9950dc47f1803
http://europepmc.org/articles/PMC2247185
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5
1,25-Dihydroxyvitamin D3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption
Autor: T. J. Chambers, P. M. J. Mcsheehy
Publikováno v: Journal of Clinical Investigation. 80:425-429
Although 1,25-dihydroxyvitamin D3 stimulates osteoclastic bone resorption in vivo and in organ culture, the mechanism by which it effects this stimulation is unknown. We have recently found that the agent does not stimulate resorption by osteoclasts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc93eb67b76b0fdd4128f3d7aa825c6d
https://doi.org/10.1172/jci113089
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6
The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells
Autor: K. Fuller, J. Pringle, T. J. Chambers, P. M. J. Mcsheehy
Publikováno v: The Journal of pathology. 145(4)
Cells were disaggregated from osteoclastomas, and the response of the giant cells to calcium-regulating hormones, prostaglandin (PG)E1 and dibutyryl cyclic AMP (dbcAMP) was observed by phase-contrast time-lapse video microscopy. The pattern and natur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e190781f1c652e67f95c63b6be3bdb3
https://pubmed.ncbi.nlm.nih.gov/2987469
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7
The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones
Autor: B. M. Thomson, K. Fuller, T. J. Chambers, P. M. J. Mcsheehy
Publikováno v: Endocrinology. 116(1)
It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622a9316a25ee6aa5f69a4bcd87544c7
https://pubmed.ncbi.nlm.nih.gov/3880540
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