Zobrazeno 1 - 9
of 9
pro vyhledávání: '"P. M. Giguère"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Representing the most attractive and successful druggable receptors of the proteome, GPCRs regulate a myriad of physiological and pathophysiological functions. Although over half of present pharmaceuticals target GPCRs, the advancement of dr
Externí odkaz:
https://doaj.org/article/fec0d6604944450cb05f7a19f09c593c
Autor:
Martin A. Rossotti, Henk van Faassen, Anh T. Tran, Joey Sheff, Jagdeep K. Sandhu, Diana Duque, Melissa Hewitt, Xiaoxue Wen, Jegarubee Bavananthasivam, Saina Beitari, Kevin Matte, Geneviève Laroche, Patrick M. Giguère, Christian Gervais, Matthew Stuible, Julie Guimond, Sylvie Perret, Greg Hussack, Marc-André Langlois, Yves Durocher, Jamshid Tanha
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
Isolation and extensive characterization of a collection of 37 anti-SARS-CoV-2 spike glycoprotein nanobodies show broad neutralization efficacies in vitro and in vivo in a hamster model of SARS-CoV-2 infection.
Externí odkaz:
https://doaj.org/article/2f48dc9abf474ef9b75e5e6b1b33d3f4
Autor:
Mehdi Benlarbi, Geneviève Laroche, Corby Fink, Kathy Fu, Rory P. Mulloy, Alexandra Phan, Ardeshir Ariana, Corina M. Stewart, Jérémie Prévost, Guillaume Beaudoin-Bussières, Redaet Daniel, Yuxia Bo, Omar El Ferri, Julien Yockell-Lelièvre, William L. Stanford, Patrick M. Giguère, Samira Mubareka, Andrés Finzi, Gregory A. Dekaban, Jimmy D. Dikeakos, Marceline Côté
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105316- (2022)
Summary: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S) binds to angiotensin-converting enzyme 2 (ACE2) to mediate membrane fusion via two distinct pathways: 1) a surface, serine protease-dependent or 2) an en
Externí odkaz:
https://doaj.org/article/b5326a00cdee4b078296e90acdff771f
Autor:
Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Angela M. Crawley, Patrick M. Giguère, Curtis Cooper, Marc-André Langlois
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103700- (2021)
Background: Antibodies raised against human seasonal coronaviruses (sCoVs), which are responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This prompts questions about their protective role against SARS-CoV-2 infections
Externí odkaz:
https://doaj.org/article/7ba81d4ec8dc43269394d064eb78b2d7
Autor:
Lynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M. Stewart, Abdulhamid O. Mohamud, Marceline Côté, Patrick M. Giguère, Marc-André Langlois, Martin Pelchat
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.
Externí odkaz:
https://doaj.org/article/6f1b37cfcbb44773b661ca22b1ff59b2
Autor:
Corina M Stewart, Alexandra Phan, Yuxia Bo, Nicholas D LeBlond, Tyler K T Smith, Geneviève Laroche, Patrick M Giguère, Morgan D Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pat
Externí odkaz:
https://doaj.org/article/c6998978276948f2b5a5a62d2e027cdc
Autor:
M. A. Rossotti, H. van Faassen, A. Tran, J. Sheff, J. K. Sandhu, D. Duque, M. Hewitt, S. Wen, R. Bavananthasivam, S. Beitari, K. Matte, G. Laroche, P. M. Giguère, C. Gervais, M. Stuible, J. Guimond, S. Perret, G. Hussack, M.-A. Langlois, Y. Durocher, J. Tanha
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs, make these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85116ef8e5a30a2f01a5348f0604352
https://doi.org/10.1101/2021.12.20.473401
https://doi.org/10.1101/2021.12.20.473401
Autor:
Dustin E Bosch, Adam J Kimple, Robin E Muller, Patrick M Giguère, Mischa Machius, Francis S Willard, Brenda R S Temple, David P Siderovski
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003040 (2012)
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoeb
Externí odkaz:
https://doaj.org/article/4362270682cc4067a9e0e1c85c876670
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