Glucocorticoid Receptor (GR) antagonism as disease-modifying treatment for MDD with childhood trauma: protocol of the RESET-medication randomized controlled trial

Autor: F. Linsen, C. Broeder, M. S. C. Sep, J. E. Verhoeven, P. M. Bet, B. W. J. H. Penninx, O. C. Meijer, C. H. Vinkers

Publikováno v: BMC Psychiatry, Vol 23, Iss 1, Pp 1-11 (2023)

Abstract Background Major depressive disorder (MDD) is a heterogeneous psychiatric disorder. Childhood trauma (CT, emotional/physical/sexual abuse or neglect before the age of 18) is one of the largest and most consistent risk factors for development

Externí odkaz: https://doaj.org/article/392365ce87254f0ba560ee373f329931

Association of CYP2D6 and CYP2C19 metabolizer status with switching and discontinuing antidepressant drugs: an exploratory study

Autor: Jurriaan M. J. L. Brouwer, Klaas J. Wardenaar, Ilja M. Nolte, Edith J. Liemburg, Pierre M. Bet, Harold Snieder, Hans Mulder, Danielle C. Cath, Brenda W. J. H. Penninx

Publikováno v: BMC Psychiatry, Vol 24, Iss 1, Pp 1-14 (2024)

Abstract Background Tailoring antidepressant drugs (AD) to patients’ genetic drug-metabolism profile is promising. However, literature regarding associations of ADs’ treatment effect and/or side effects with drug metabolizing genes CYP2D6 and CYP

Externí odkaz: https://doaj.org/article/61fa815c9a504b8985aa02bad90433c4

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19

Autor: Leila Atmowihardjo, Job R. Schippers, Imke H. Bartelink, Pierre M. Bet, Nienke van Rein, Keith Purdy, David Cavalla, Valérie Comberiati, Andrew McElroy, Sue D. Snape, Harm Jan Bogaard, Leo Heunks, Nicole Juffermans, Marcus Schultz, Pieter R. Tuinman, Lieuwe D. J. Bos, Jurjan Aman

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-17 (2022)

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to a disruptive increase in the number of intensive care unit (ICU) admissions with acute respiratory distress syndrome (ARDS). ARDS is a severe, life-threatening medical co

Externí odkaz: https://doaj.org/article/27dbdb47d79d4a0092fff3b3856e4135

Rivastigmine for ECT-induced cognitive adverse effects in late life depression (RECALL study): A multicenter, randomized, double blind, placebo-controlled, cross-over trial in patients with depression aged 55 years or older: Rationale, objectives and methods

Autor: Marieke J. Henstra, Thomas C. Feenstra, Rob M. Kok, Harm-Pieter Spaans, Eric van Exel, Annemiek Dols, Mardien Oudega, Anton C. M. Vergouwen, Adriano van der Loo, Pierre M. Bet, Stephan A. Loer, Merijn Eikelenboom, Pascal Sienaert, Simon Lambrichts, Filip Bouckaert, Judith E. Bosmans, Nathalie van der Velde, Aartjan T. F. Beekman, Max L. Stek, Didi Rhebergen

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

BackgroundCognitive side-effects are an important reason for the limited use of electroconvulsive therapy (ECT). Cognitive side-effects are heterogeneous and occur frequently in older persons. To date, insight into these side-effects is hampered due

Externí odkaz: https://doaj.org/article/05849dcdd85d453c8fbb5959a0a507e3

A new approach to drug intravenous compatibility research: The case of obstetric parenteral drugs

Autor: A F Leeuwerik, L N van Merendonk, M A de Boer, A J Wilhelm, A Kolkman, P M Bet

Publikováno v: European Journal of Hospital Pharmacy. European Association of Hospital Pharmacists (EAHP)
Leeuwerik, A F, van Merendonk, L N, de Boer, M A, Wilhelm, A J, Kolkman, A & Bet, P M 2023, ' A new approach to drug intravenous compatibility research : The case of obstetric parenteral drugs ', European Journal of Hospital Pharmacy . https://doi.org/10.1136/ejhpharm-2022-003577

Objectives: The product information and literature does not provide confirmation of compatibility for co-administration of all commonly used drug pairs in obstetrics. However, there is a need for co-administration of these drugs over one lumen for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600783a585c7f3022de59bfdb4f2133
https://research.vumc.nl/en/publications/26e92c26-3659-4100-8491-95ab3ee8e8a5