Zobrazeno 1 - 10
of 117
pro vyhledávání: '"P. M. Ashley"'
Autor:
Pauline Latzer, Henning Zelba, Florian Battke, Annekathrin Reinhardt, Borong Shao, Oliver Bartsch, Armin Rabsteyn, Johannes Harter, Martin Schulze, Thomas Okech, Alexander Golf, Christina Kyzirakos-Feger, Simone Kayser, Natalia Pieper, Magdalena Feldhahn, Julian Wünsche, Christian Seitz, Dirk Hadaschik, Claus Garbe, Till-Karsten Hauser, Christian la Fougère, Dirk Biskup, Dawn Brooke, David Parker, Uwe M. Martens, Gerald Illerhaus, Deborah T. Blumenthal, Ryan Merrell, Luisa Sánchez Lorenzo, Máté Hidvégi, Paula de Robles, Sied Kebir, William W. Li, Vincent W. Li, Matthew Williams, Alexandra M. Miller, Santosh Kesari, Michael Castro, Annick Desjardins, David M. Ashley, Henry S. Friedman, Patrick Y. Wen, Elisabeth C. Neil, Fabio M. Iwamoto, Bence Sipos, Karsten Geletneky, Lars Zender, Martin Glas, David A. Reardon, Saskia Biskup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized
Externí odkaz:
https://doaj.org/article/98a07e6f1b4647369483ebef527a8f94
Autor:
Mengyi Liu, Zhicheng Ji, Vaibhav Jain, Vanessa L. Smith, Emily Hocke, Anoop P. Patel, Roger E. McLendon, David M. Ashley, Simon G. Gregory, Giselle Y. López
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Glioblastoma (GBM) remains an untreatable malignant tumor with poor patient outcomes, characterized by palisading necrosis and microvascular proliferation. While single-cell technology made it possible to characterize different lineage of gl
Externí odkaz:
https://doaj.org/article/15939242c18842f1a4a601f94efff0d5
Autor:
Liliana S McKay, Alexa R Spandrio, Richard M Johnson, M Ashley Sobran, Sara A Marlatt, Katlyn B Mote, Margaret R Dedloff, Zachary M Nash, Steven M Julio, Peggy A Cotter
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012084 (2024)
Little is known about oxygen utilization during infection by bacterial respiratory pathogens. The classical Bordetella species, including B. pertussis, the causal agent of human whooping cough, and B. bronchiseptica, which infects nearly all mammals,
Externí odkaz:
https://doaj.org/article/d770532abf8a4c2190520d596f075ad2
Autor:
Joshua A. Regal, María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, Zachary J. Reitman
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/01b4c740b36b4a8ca05ca73eba28ca23
Autor:
Seethalakshmi Hariharan, Benjamin T. Whitfield, Christopher J. Pirozzi, Matthew S. Waitkus, Michael C. Brown, Michelle L. Bowie, David M. Irvin, Kristen Roso, Rebecca Fuller, Janell Hostettler, Sharvari Dharmaiah, Emiley A. Gibson, Aaron Briley, Avani Mangoli, Casey Fraley, Mariah Shobande, Kevin Stevenson, Gao Zhang, Prit Benny Malgulwar, Hannah Roberts, Martin Roskoski, Ivan Spasojevic, Stephen T. Keir, Yiping He, Maria G. Castro, Jason T. Huse, David M. Ashley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional imm
Externí odkaz:
https://doaj.org/article/93956c3a4d2c4721a96aa5db55f8df28
Autor:
Michael A Sun, Haipei Yao, Qing Yang, Christopher J Pirozzi, Vidyalakshmi Chandramohan, David M Ashley, Yiping He
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299820 (2024)
Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Through gene expression
Externí odkaz:
https://doaj.org/article/744d6e5623f04a11bead05c2b93942ac
Autor:
Joshua A. Regal, María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, Zachary J. Reitman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-30 (2023)
Abstract Gangliogliomas are brain tumors composed of neuron-like and macroglia-like components that occur in children and young adults. Gangliogliomas are often characterized by a rare population of immature astrocyte-appearing cells expressing CD34,
Externí odkaz:
https://doaj.org/article/d9a27d880bbe4ad09edb99a558ed71db
Autor:
William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Responses to immune checkpoint blockade (ICB) in patients with glioblastoma are limited. Here the authors show that Calmodulin-Dependent Kinase Kinase 2 (CaMKK2) is expressed in tumor associated macrophages and neurons and is associated with resistan
Externí odkaz:
https://doaj.org/article/d2bad1bc29a045f7afdb7b2e7787b8de
Akademický článek
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Autor:
Daniel Landi, Annick Desjardins, Matthias Gromeier, Darell D Bigner, Smita K Nair, Michael C Brown, Georgia M Beasley, David M Ashley, Yuanfan Yang, Zachary P McKay, Dina M Randazzo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Antitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4+ T cells hold potential to be leveraged for this purpose. Moreover
Externí odkaz:
https://doaj.org/article/73dcacec3cd343d394456d6088d99ca1