Výsledky vyhledávání - "P. Lynne Simmonds"

The Contribution of Dental Amalgam to Urinary Mercury Excretion in Children

Autor: Michael D. Martin, Ying Huang, Brian G. Leroux, John V. Kushleika, P. Lynne Simmonds, Jorge Leitão, Mario Bernardo, Timothy A. DeRouen, Henrique Luis, James S. Woods

Publikováno v: Environmental Health Perspectives
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Much attention has focused on potential adverse health effects associated with exposure to mercury and mercury compounds. Of particular public health concern has been possible neurologic impairment associated with prolonged exposure to elemental merc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9210f1a7ec4fa68881f46e63094ac58b
http://europepmc.org/articles/PMC2022658

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The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans

Autor: Nicholas J. Heyer, James S. Woods, Federico M. Farin, Diana Echeverria, P. Lynne Simmonds, Jasmine Wilkerson

Publikováno v: Toxicology and Applied Pharmacology. 206:113-120

Previous studies have demonstrated highly specific urinary porphyrin profile (UPP) changes in response to mercury (Hg) exposure in animals and human subjects and have defined the biochemical etiology of this effect as selective alteration of the heme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7640df65bddadb48a56b9cb879698814
https://doi.org/10.1016/j.taap.2004.12.016

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Nuclear Factor B Activity Determines the Sensitivity of Kidney Epithelial Cells to Apoptosis: Implications for Mercury-Induced Renal Failure

Autor: William W. Polk, P. Lynne Simmonds, John V. Kushleika, Francisco J. Dieguez-Acuna, James S. Woods, Maureen E. Ellis

Publikováno v: Toxicological Sciences. 82:114-123

Nuclear factor kappa B (NF-kappaB) is a thiol-dependent transcriptional factor that promotes cell survival and protects cells from apoptotic stimuli. Numerous studies have demonstrated increased sensitivity to apoptosis associated with inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d866398fc65f704e321ea09681b095
https://doi.org/10.1093/toxsci/kfh236

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Attenuation of nuclear factor kappa B (NF-kappaB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity

Autor: Francisco J. Dieguez-Acuña, P. Lynne Simmonds, Maureen E. Ellis, James S. Woods, John V. Kushleika

Publikováno v: Environmental Health Perspectives

Nuclear factor kappa B (NF-kappaB), a pleiotropic transcriptional factor that promotes cell survival and protects cells from apoptosis, requires reduced thiols at critical steps in its activation pathway. Mercuric ion (Hg(2+)), one of the strongest t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b1548f0564b197b5529d2294abfd97
http://europepmc.org/articles/PMC1241252

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Effects of 2,3-Dimercapto-1-propanesulfonic Acid (DMPS) on Tissue and Urine Mercury Levels following Prolonged Methylmercury Exposure in Rats

Autor: Stephanie D. Pingree, P. Lynne Simmonds, James S. Woods

Publikováno v: Toxicological Sciences. 61:224-233

Methylmercury, a potent neurotoxicant, accumulates in the brain as well as the kidney during chronic exposure. We evaluated the capacity of 2,3-dimercapto-1-propanesulfonic acid (DMPS), a tissue-permeable metal chelator, to reduce brain, kidney, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e130aa0cf088d93389d770471bab355
https://doi.org/10.1093/toxsci/61.2.224

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Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam Trial

Autor: P. Lynne Simmonds, Diana Echeverria, Jorge Leitão, Mario Bernardo, Henrique Luis, Michael D. Martin, Timothy A. DeRouen, Brian G. Leroux, Tessa Rue, James S. Woods

Publikováno v: Journal of toxicology and environmental health. Part A. 72(14)

Increases in the urinary concentrations of pentacarboxyl- and coproporphyrins and the appearance of the atypical precoproporphyrin have been defined in relation to mercury (Hg) body burden in animal studies, and this change in the porphyrin excretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a393af31867fa9f05d5451a09f2f05
https://pubmed.ncbi.nlm.nih.gov/19557617

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Urinary porphyrin excretion in normal children and adolescents

Autor: Timothy A. DeRouen, Michael D. Martin, Jorge Leitão, Mario Bernardo, Tessa Rue, James S. Woods, P. Lynne Simmonds, Henrique Luis, Brian G. Leroux

Publikováno v: Clinica chimica acta; international journal of clinical chemistry. 405(1-2)

Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable.Subjects were participants in a prospective, random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b8212ee302dbf3349e137c67aaa435
https://pubmed.ncbi.nlm.nih.gov/19394319

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RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells

Autor: James S. Woods, John V. Kushleika, William W. Polk, P. Lynne Simmonds, Maureen E. Ellis

Publikováno v: American journal of physiology. Cell physiology. 293(3)

Numerous studies have demonstrated a central role of renal tubular epithelial cells in the etiology of kidney injury and disease through the elaboration of inflammatory mediators. However, little is known about the cellular signaling mechanisms invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbd4cbb2d94336d82877930280f94ed
https://pubmed.ncbi.nlm.nih.gov/17615156

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Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats

Autor: Stephanie D. Pingree, Kevin T. Rummel, P. Lynne Simmonds, James S. Woods

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 61(2)

Changes in urinary porphyrin excretion patterns (porphyrin profiles) during prolonged mercury exposure are attributable to mercury accumulation in the kidney and to consequent effects of Hg2+ on renal porphyrin metabolism. In the present study, we ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87723d49f171ea801694c28773b196b
https://pubmed.ncbi.nlm.nih.gov/11353126

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