Zobrazeno 1 - 10
of 125
pro vyhledávání: '"P. Losana"'
Autor:
Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M. Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C. Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G. Gomez-Lorenzo
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100537- (2024)
Target-based approaches have traditionally been used in the search for new anti-infective molecules. Target selection process, a critical step in Drug Discovery, identifies targets that are essential to establish or maintain the infection, tractable
Externí odkaz:
https://doaj.org/article/d92953ce83374169adecd4b1d6033c9a
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Roch Christian Johnson, Emma Sáez-López, Esaï Sèdjro Anagonou, Godwin Gérard Kpoton, Adjimon Gilbert Ayelo, Ronald Sètondji Gnimavo, Franck Zinsou Mignanwande, Jean-Gabin Houezo, Ghislain Emmanuel Sopoh, Juliet Addo, Lindsay Orford, Georgios Vlasakakis, Nandita Biswas, Felix Calderon, Oscar Della Pasqua, Anna Gine-March, Zaida Herrador, Alfonso Mendoza-Losana, Gabriel Díez, Israel Cruz, Santiago Ramón-García
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans that affects skin, soft tissues, and bones, causing long-term morbidity, stigma, and disability. The recommended treatment for BU requires 8 weeks
Externí odkaz:
https://doaj.org/article/4d85c177d23b40b99d3862d20e38bcbe
Autor:
Pablo Conesa, Yunior C. Fonseca, Jorge Jiménez de la Morena, Grigory Sharov, Jose Miguel de la Rosa-Trevín, Ana Cuervo, Alberto García Mena, Borja Rodríguez de Francisco, Daniel del Hoyo, David Herreros, Daniel Marchan, David Strelak, Estrella Fernández-Giménez, Erney Ramírez-Aportela, Federico Pedro de Isidro-Gómez, Irene Sánchez, James Krieger, José Luis Vilas, Laura del Cano, Marcos Gragera, Mikel Iceta, Marta Martínez, Patricia Losana, Roberto Melero, Roberto Marabini, José María Carazo, Carlos Oscar Sánchez Sorzano
Publikováno v:
Biological Imaging, Vol 3 (2023)
Image-processing pipelines require the design of complex workflows combining many different steps that bring the raw acquired data to a final result with biological meaning. In the image-processing domain of cryo-electron microscopy single-particle a
Externí odkaz:
https://doaj.org/article/7e0c16ca201946a0af77da21601e8521
Autor:
Roberto Melero, Carlos Oscar S. Sorzano, Brent Foster, José-Luis Vilas, Marta Martínez, Roberto Marabini, Erney Ramírez-Aportela, Ruben Sanchez-Garcia, David Herreros, Laura del Caño, Patricia Losana, Yunior C. Fonseca-Reyna, Pablo Conesa, Daniel Wrapp, Pablo Chacon, Jason S. McLellan, Hemant D. Tagare, Jose-Maria Carazo
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1059-1069 (2020)
Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions
Externí odkaz:
https://doaj.org/article/882a529feb224c03b4fe56e24b963384
Autor:
Clement K. M. Tsui, Flavia Sorrentino, Gagandeep Narula, Alfonso Mendoza-Losana, Ruben Gonzalez del Rio, Esther Pérez Herrán, Abraham Lopez, Adama Bojang, Xingji Zheng, Modesto Jesus Remuiñán-Blanco, Yossef Av-Gay
Publikováno v:
Molecules, Vol 27, Iss 14, p 4446 (2022)
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Chemical-genetic characterization through in vitro evolution combined with whole genome sequencing analysis was us
Externí odkaz:
https://doaj.org/article/f85721612f414ebf85bdd94ae33aa7c0
Autor:
Adrian Richter, Ines Rudolph, Ute Möllmann, Kerstin Voigt, Chun-wa Chung, Onkar M. P. Singh, Michael Rees, Alfonso Mendoza-Losana, Robert Bates, Lluís Ballell, Sarah Batt, Natacha Veerapen, Klaus Fütterer, Gurdyal Besra, Peter Imming, Argyrides Argyrou
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Nitro-substituted 1,3-benzothiazinones (nitro-BTZs) are mechanism-based covalent inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose-2′-oxidase (DprE1) with strong antimycobacterial properties. We prepared a number of
Externí odkaz:
https://doaj.org/article/6734673c6fd94ca783944bd94b6c5f5b
Autor:
Maria G. Gomez-Lorenzo, Ane Rodríguez-Alejandre, Sonia Moliner-Cubel, María Martínez-Hoyos, Noemí Bahamontes-Rosa, Rubén Gonzalez del Rio, Carolina Ródenas, Jesús de la Fuente, Jose Luis Lavandera, Jose F. García-Bustos, Alfonso Mendoza-Losana
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 295-303 (2018)
Phenotypic screening has produced most of the new chemical entities currently in clinical development for malaria, plus many lead compounds active against Plasmodium falciparum asexual stages. However, lack of knowledge about the mode of action of th
Externí odkaz:
https://doaj.org/article/d31fe5e392d8459fb92b14da48cc417a